Elucidation of the influence and mechanism of sarcopenia on lower limb ischemia and angiogenesis therapy

Research Project

Project/Area Number	16K19433
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cardiovascular medicine
Research Institution	Kurume University
Principal Investigator	sasaki motoki 久留米大学, 医学部, 助教 (60725026)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	サルコペニア / 血管新生 / 下肢虚血 / 臨床血管学
Outline of Final Research Achievements	Sarcopenia model mice produced by our own method showed significantly lowering of the weight of the lower limbs as compared with the control mice.Significant atrophy was observed macroscopically and microscopically in the lower limb muscle.Subsequently, limb ischemia was added to sarcopenia model mice and control mice.Blood flow evaluation by laser Doppler was performed for each mouse.As a result, there was a significant decrease in blood flow in the sarcopenia model mice as compared with the control mice.The mechanism of blood flow reduction in sarcopenia model mice is unknown, and further examination is required.