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The role of proliferative reaction in molecular pathogenesis of aortic dissection

Research Project

Project/Area Number 16K19434
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionKurume University

Principal Investigator

Hayashi Makiko  久留米大学, 医学部, 助教 (70725027)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大動脈解離 / mTOR / 増殖応答 / 平滑筋細胞 / 炎症応答
Outline of Final Research Achievements

Preventive administration of rapamycin completely inhibited aortic dissection (AD) development in mouse AD model. DNA microarray revealed the proliferative reaction in mouse aortic tissue before AD development, and rapamycin selectively suppressed the cell proliferation. Immunostaining revealed the proliferation of smooth muscle cells (SMCs), fibroblasts, and monocytes in aortic tissue. Protein assay revealed that rapamycin induced the expression of SM2 known as a marker of differentiated SMCs. In addition, treatment with rapamycin after AD development effectively suppressed the progression of AD in mouse AD model.
We concluded that mTOR promotes AD development via cell proliferation, and also plays an important role in AD progression.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (22 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results)

  • [Journal Article] Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection2018

    • Author(s)
      Ohno‐Urabe Satoko、Aoki Hiroki、Nishihara Michihide、Furusho Aya、Hirakata Saki、Nishida Norifumi、Ito Sohei、Hayashi Makiko、Yasukawa Hideo、Imaizumi Tsutomu、Akashi Hidetoshi、Tanaka Hiroyuki、Fukumoto Yoshihiro
    • Journal Title

      Journal of the American Heart Association

      Volume: 7 Issue: 2

    • DOI

      10.1161/jaha.117.007389

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of B Cells, Immunoglobulins, and Syk in the Pathogenesis of Abdominal Aortic Aneurysm2018

    • Author(s)
      Furusho Aya、Aoki Hiroki、Ohno‐Urabe Satoko、Nishihara Michihide、Hirakata Saki、Nishida Norifumi、Ito Sohei、Hayashi Makiko、Imaizumi Tsutomu、Hiromatsu Shinichi、Akashi Hidetoshi、Tanaka Hiroyuki、Fukumoto Yoshihiro
    • Journal Title

      Journal of the American Heart Association

      Volume: 7 Issue: 6

    • DOI

      10.1161/jaha.117.007750

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice2017

    • Author(s)
      Nishihara Michihide、Aoki Hiroki、Ohno Satoko、Furusho Aya、Hirakata Saki、Nishida Norifumi、Ito Sohei、Hayashi Makiko、Imaizumi Tsutomu、Fukumoto Yoshihiro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 10 Pages: e0185923-e0185923

    • DOI

      10.1371/journal.pone.0185923

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] MRTF-A Mediates Development of Aortic Dissection Through Aortic Smooth Muscle Cell Apoptosis and Inflammatory Response2018

    • Author(s)
      Sohei Ito, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumoto
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Macrophage Stat3 Exacerbates Aortic Dissection through Dysregulated Differentiation of Macrophages and Smooth Muscle2018

    • Author(s)
      Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumoto
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] nvolvement of B cell/Syk axis in Development of Abdominal Aortic Aneurysm2018

    • Author(s)
      Aya Furusho, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumoto
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stat3 in smooth muscle cells prevents progression of aortic dissection by reinforcing the physical strength of aortic walls2018

    • Author(s)
      Saki Hirakata, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumoto
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] High Salt and IL-17 Synergistically Worsen Aortic Dissection by Dysregulation of Extracellular Matrix2018

    • Author(s)
      Norifumi Nishida, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Sohei Ito, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumoto
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] mTOR regulates development and progression of aortic dissection2018

    • Author(s)
      Makiko Hayashi, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Yohei Hashimoto, Ryohei Majima, Yoshihiro Fukumoto
    • Organizer
      第1回 日本循環器学会基礎研究フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 解離病態における増殖応答を介するmTORの役割2018

    • Author(s)
      林 真貴子
    • Organizer
      第59回日本脈管学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Central Role of mTOR Pathway in Molecular Pathogenesis of Aortic Dissection2017

    • Author(s)
      Makiko Hayashi, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Yoshihiro Fukumoto
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢市教育プラザ(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] STAT3 Determines Differntiation of Macrophages and Progression of Aortic Dissection2017

    • Author(s)
      Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢市教育プラザ(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] High Salt ActivatesNFkB Pathway and Causes Worsening of Arotic Dissection Via IL-17 Pathway2017

    • Author(s)
      Norifumi Nishida, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢フォーラス(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] B Cells Promote the Progression of Aortic Dissection through a Proinflammatory Response2017

    • Author(s)
      Aya Furusho, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢市教育プラザ(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Myocardin-related Transcription Factor-A is Required for Drvrlopment of Aortic Dissection2017

    • Author(s)
      Sohei Ito, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      ヴィサージュ(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] mTOR Promotes Aortic Dissection Through Cell Proliferation2017

    • Author(s)
      Makiko Hayashi1.Makiko Hayashi, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Yoshihiro Fukumoto
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MRTF-A Mediates Development of Aortic Dissection Through Aortic Smooth Muscle Cell Apoptosis and Inflammatory Response2017

    • Author(s)
      Sohei Ito, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumoto
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myocardin-related transcription factor-A is required for development of aortic dissection2017

    • Author(s)
      Sohei Ito, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumoto
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] mTOR promotes aortic dissection through cell proliferation2017

    • Author(s)
      林 真貴子
    • Organizer
      第123回日本循環器学会九州地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Macrophage Socs3 is the Determinant for the Development of Aortic Dissection2016

    • Author(s)
      Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
    • Organizer
      AHA 2016
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Myocardin-Related Transcription Factor-A is Requilred for Development of Aortic Dissection2016

    • Author(s)
      Sohei Ito, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      AHA 2016
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Macrophage STAT3 activation promotes aortic dissection via imbalance of tissue destruction and protection2016

    • Author(s)
      Satoko Ohno, Hiroki Aoki、Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Rome (Italy)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] B cells promote abdominal aortic aneurysm and aortic dissection through proinflammatory function of immunoglobulins2016

    • Author(s)
      Aya Furusho, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Rome (Italy)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] STAT3 in vascular smooth muscle cells protects aorta from dissection by reinforcing extracellular matrix2016

    • Author(s)
      Saki Hirakata, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Rome (Italy)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molecular mechanisms of worsening aortic dissection by high salt through IL-17 pathway2016

    • Author(s)
      Norifumi Nishida, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Rome (italy)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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