| Project/Area Number |
16K19434
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大動脈解離 / mTOR / 増殖応答 / 平滑筋細胞 / 炎症応答 |
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| Outline of Final Research Achievements |
Preventive administration of rapamycin completely inhibited aortic dissection (AD) development in mouse AD model. DNA microarray revealed the proliferative reaction in mouse aortic tissue before AD development, and rapamycin selectively suppressed the cell proliferation. Immunostaining revealed the proliferation of smooth muscle cells (SMCs), fibroblasts, and monocytes in aortic tissue. Protein assay revealed that rapamycin induced the expression of SM2 known as a marker of differentiated SMCs. In addition, treatment with rapamycin after AD development effectively suppressed the progression of AD in mouse AD model.
We concluded that mTOR promotes AD development via cell proliferation, and also plays an important role in AD progression.
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