The role of proliferative reaction in molecular pathogenesis of aortic dissection
Project/Area Number |
16K19434
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
|
Research Institution | Kurume University |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 大動脈解離 / mTOR / 増殖応答 / 平滑筋細胞 / 炎症応答 |
Outline of Final Research Achievements |
Preventive administration of rapamycin completely inhibited aortic dissection (AD) development in mouse AD model. DNA microarray revealed the proliferative reaction in mouse aortic tissue before AD development, and rapamycin selectively suppressed the cell proliferation. Immunostaining revealed the proliferation of smooth muscle cells (SMCs), fibroblasts, and monocytes in aortic tissue. Protein assay revealed that rapamycin induced the expression of SM2 known as a marker of differentiated SMCs. In addition, treatment with rapamycin after AD development effectively suppressed the progression of AD in mouse AD model. We concluded that mTOR promotes AD development via cell proliferation, and also plays an important role in AD progression.
|
Report
(3 results)
Research Products
(25 results)
-
[Journal Article] Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection2018
Author(s)
Ohno‐Urabe Satoko、Aoki Hiroki、Nishihara Michihide、Furusho Aya、Hirakata Saki、Nishida Norifumi、Ito Sohei、Hayashi Makiko、Yasukawa Hideo、Imaizumi Tsutomu、Akashi Hidetoshi、Tanaka Hiroyuki、Fukumoto Yoshihiro
-
Journal Title
Journal of the American Heart Association
Volume: 7
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
[Presentation] mTOR regulates development and progression of aortic dissection2018
Author(s)
Makiko Hayashi, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Yohei Hashimoto, Ryohei Majima, Yoshihiro Fukumoto
Organizer
第1回 日本循環器学会基礎研究フォーラム
Related Report
-
-
-
[Presentation] STAT3 Determines Differntiation of Macrophages and Progression of Aortic Dissection2017
Author(s)
Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
Organizer
第81回日本循環器学会学術集会
Place of Presentation
金沢市教育プラザ(石川県金沢市)
Year and Date
2017-03-17
Related Report
-
-
[Presentation] B Cells Promote the Progression of Aortic Dissection through a Proinflammatory Response2017
Author(s)
Aya Furusho, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
Organizer
第81回日本循環器学会学術集会
Place of Presentation
金沢市教育プラザ(石川県金沢市)
Year and Date
2017-03-17
Related Report
-
-
-
-
-
-
-
-
-
-
-