Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
This study was aimed to examine a possible role of secreted phospholipase A2 (sPLA2) in cardiovascular diseases, and to develop a new stratagy to prevent from cardiovascular diseases. As a result, group V sPLA2 is the major sPLA2 isoform expressed in aortic endothelial cells, releases oleic and linoleic acid in response to angiotensin II stimulation, and protects against acute aortic dissection in a manner dependent upon lysyloxidase-dependent extra cellular matrix stabilization.
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