PD-1 positive T cells in pulmonary Mycobacterium avium infection

• Project/Area Number: 16K19440
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: MITSUHASHI YOSHIYA 東北大学, 医学系研究科, 非常勤講師 (70754513)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 非結核性抗酸菌症 / PD-1陽性T細胞 / 免疫疲労 / PD-L1 / PD-1 / PD-1 陽性Ｔ細胞 / 感染症

Outline of Final Research Achievements

Pulmonary Mycobacterium avium and intracellular infectious diseases has become an important health-care problem because its prevalence is increasing. We hypothesized that programmed cell death (PD)-1 might be upregulated in T-cells of the patients with pulmonary Mycobacterium avium infection, which would contribute to attenuated cellular immunity. Then, we examined the expression of PD-1 in T cells in the samples of peripheral blood mononuclear cells derived from age and sex matched healthy controls and the patients with pulmonary Mycobacterium avium infection. The percentage of PD-1 positive cells in both CD4 positive T cells and CD8 positive cells were significantly decreased in the patients comparing with healthy controls. In contrast to previous reports about PD-1 T cells in chronic inflammation and infection including chronic hepatitis, pulmonary Mycobacterium avium infection may not induce T-cell exhaustion.

Research Products

• [Journal Article] Invasive pulmonary mucormycosis: rare presentation with pulmonary eosinophilia. (2017)
  • Author(s): Hirano T, Yamada M, Sato K, Murakami K, Tamai T, Mitsuhashi Y, Tamada T, Sugiura H, Sato N, Saito R, Tominaga J, Watanabe A, Ichinose M.
  • Journal Title: BMC Pulm Med Volume: 17 Issue: 1 Pages: 76-76
  • DOI: 10.1186/s12890-017-0419-1
  • Peer Reviewed / Open Access
• [Journal Article] 【呼吸器疾患とマイクロバイオーム】 肺のマイクロバイオーム (2017)
  • Author(s): 三橋 善哉
  • Journal Title: THE LUNG-perspectives Volume: 25 Pages: 153-158
• [Journal Article] 両下肢麻痺を来たした肺真菌症の1例 (2017)
  • Author(s): 佐藤 慶, 山田 充啓, 平野 泰三, 三橋 善哉, 岡崎 達馬, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和
  • Journal Title: 日本内科学会雑誌 Volume: 106 Pages: 591-595
  • NAID: 130006470818