• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidating a potential mechanistic link between altering lipid metabolism on the alveolar type II epithelial cells and pathogenesis of pulmonary fibrosis and pulmonary emphysema

Research Project

Project/Area Number 16K19442
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionGunma University

Principal Investigator

SUNAGA HIROAKI  群馬大学, 大学院医学系研究科, 研究員 (10760077)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脂肪酸組成 / リン脂質 / 肺線維症 / 肺気腫 / 飽和脂肪酸 / 不飽和脂肪酸 / 肺胞上皮細胞 / 喫煙 / 脂肪酸分画 / 触媒酵素 / 脂肪酸 / Ⅱ型肺胞上皮細胞
Outline of Final Research Achievements

Despite the established role of alveolar type II epithelial cells for the maintenance of pulmonary function and synthesis of pulmonary surfactant, little is known about the deregulation of lipid metabolism in the pathogenesis of pulmonary fibrosis and pulmonary emphysema. We have focused on the elongase of long chain fatty acids family 6 (Elovl6) which is a catalytic enzyme that elongates of saturated and monounsaturated long chain fatty acids in the lung. We used pulmonary fibrosis and pulmonary emphysema model of wild type (WT) mice and Elovl6-null (Elovl6-/-) mice. Interestingly, Elovl6-mediated derangement of fatty acid composition lead to change of apoptosis and differentiation, and alteration of expression of phospholipid synthetase such as LPCAT1 and LPCAT4, resulting in progression of lung disease. Our findings suggest that regulation of lipid metabolism by Elovl6 would become a new therapeutic target for pulmonary fibrosis and pulmonary emphysema.

Academic Significance and Societal Importance of the Research Achievements

本研究結果により、Ⅱ型肺胞上皮細胞における脂質代謝の変化が肺線維症および肺気腫の病態形成に関与することが見い出せた。また、食事中の脂肪酸の組成やバランス、糖尿病などの疾患に伴う体内の脂肪酸組成の変化が病態の発症および進展に関わる可能性が示唆された。Elovl6酵素の発現や活性変化に伴う脂肪酸組成の変化が病態形成に重要であることから、今後は、生活習慣と肺疾患発症との因果関係の解明や、Elovl6の発現や活性を制御する食事成分、薬剤の解明などを行うことで肺疾患予防・治療への効果が期待でき、その波及効果は大きいと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (56 results)

All 2019 2018 2017 2016 Other

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 13 results,  Acknowledgement Compliant: 3 results) Presentation (39 results) (of which Int'l Joint Research: 7 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity2019

    • Author(s)
      Masubuchi Hiroaki、Ueno Manabu、Maeno Toshitaka、Yamaguchi Koichi、Hara Kenichiro、Sunaga Hiroaki、Matsui Hiroki、Nagasawa Masahiro、Kojima Itaru、Iwata Yuko、Wakabayashi Shigeo、Kurabayashi Masahiko
    • Journal Title

      BMC Pulmonary Medicine

      Volume: 19 Issue: 1 Pages: 70-70

    • DOI

      10.1186/s12890-019-0821-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise endurance capacity ismarkedly reduced due to impaired energy homeostasis during prolonged fasting inFABP4/5 deficient mice.2019

    • Author(s)
      Iso T, Haruyama H, Sunaga H, Matsui M, Matsui H, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Yokoyama T, Kurabayashi M.
    • Journal Title

      BMC Physiol.

      Volume: 19(1) Issue: 1 Pages: 1-10

    • DOI

      10.1186/s12899-019-0038-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption2018

    • Author(s)
      Shrestha S, Sunaga H, Hanaoka H, Yamaguchi A, Kuwahara S, Umbarawan Y, Nakajima K, Machida T, Murakami M, Saito A, Tsushima Y, Kurabayashi M, Iso T
    • Journal Title

      Sci Rep

      Volume: 8(1) Issue: 1 Pages: 16451-16451

    • DOI

      10.1038/s41598-018-34902-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD36 is indispensable for nutrient homeostasis and endurance exercise capacity during prolonged fasting2018

    • Author(s)
      Iso T, Haruyama H, Sunaga H, Matsui H, Matsui M, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Putri M, Yamaguchi A, Hanaoka H, Negishi K, Yokoyama T, Kurabayashi M
    • Journal Title

      Physiol Rep

      Volume: 6(19) Issue: 19 Pages: e13884-e13884

    • DOI

      10.14814/phy2.13884

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure2018

    • Author(s)
      Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
    • Journal Title

      Sci Rep

      Volume: 8(1) Issue: 1 Pages: 12035-12035

    • DOI

      10.1038/s41598-018-30616-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid binding protein-4 and -5 knockout mice.2018

    • Author(s)
      Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
    • Journal Title

      Cardiovasc Res.

      Volume: - Issue: 8 Pages: 1132-1144

    • DOI

      10.1093/cvr/cvy063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction2017

    • Author(s)
      Obokata M, Iso T, Ohyama Y, Sunaga H, Kawaguchi T, Matsui H, Iizuka T, Fukuda N, Takamatsu H, Koitabashi N, Funada R, Takama N, Kasama S, Kaneko Y, Yokoyama T, Murakami M, Kurabayashi M
    • Journal Title

      European Heart Journal: Acute Cardiovascular Care

      Volume: 印刷中 Issue: 6 Pages: 561-569

    • DOI

      10.1177/2048872616683635

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association Between Circulating Ketone Bodies and Worse Outcomes in Hemodialysis Patients2017

    • Author(s)
      Obokata Masaru、Negishi Kazuaki、Sunaga Hiroaki、Ishida Hideki、Ito Kyoko、Ogawa Tetsuya、Iso Tatsuya、Ando Yoshitaka、Kurabayashi Masahiko
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 10

    • DOI

      10.1161/jaha.117.006885

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice.2017

    • Author(s)
      Umbarawan Y, Syamsunarno MR, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
    • Journal Title

      Metabolism, clinical and experimental.

      Volume: - Pages: 47-57

    • DOI

      10.1016/j.metabol.2017.09.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise2017

    • Author(s)
      Iso Tatsuya、Sunaga Hiroaki、Matsui Hiroki、Kasama Shu、Oshima Naomi、Haruyama Hikari、Furukawa Nozomi、Nakajima Kiyomi、Machida Tetsuo、Murakami Masami、Yokoyama Tomoyuki、Kurabayashi Masahiko
    • Journal Title

      Clinical Biochemistry

      Volume: 50 Issue: 16-17 Pages: 896-902

    • DOI

      10.1016/j.clinbiochem.2017.05.021

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krupple-Like Factor 4 (AMPK/KLF4) Signaling.2016

    • Author(s)
      Sunaga H, Matsui H, Anjo S, Syamsunarno MR, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M
    • Journal Title

      J Am Heart Assoc.

      Volume: 5 Issue: 12

    • DOI

      10.1161/jaha.116.004014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fibroblast growth factor 23 inhibits osteoblastic gene expression and induces osteoprotegerin in vascular smooth muscle cells.2016

    • Author(s)
      Nakahara T, Kawai-Kowase K, Matsui H, Sunaga H, Utsugi T, Iso T, Arai M, Tomono S, Kurabayashi M.
    • Journal Title

      Atherosclerosis

      Volume: 29 Pages: 102-110

    • DOI

      10.1016/j.atherosclerosis.2016.08.010

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Independent and Incremental Prognostic Value of Novel Cardiac Biomarkers in Chronic Hemodialysis Patients2016

    • Author(s)
      Masaru Obokata, Hiroaki Sunaga, Hideki Ishida, Kyoko Ito, Tetsuya Ogawa, Yoshitaka Ando, Masahiko Kurabayashi, Kazuaki Negishi
    • Journal Title

      Am Heart J.

      Volume: 179 Pages: 29-41

    • DOI

      10.1016/j.ahj.2016.05.018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Genetic deletion of fatty acid synthase in vascular smooth muscle cell ameliorates monocrotaline-induced PAH in mice2019

    • Author(s)
      Satoko Furukawa、Hiroki Matsui、Nozomi Furukawa、Hiroaki Sunaga、Tatsuya Iso、Masahiko Kurabayashi、Tomoyuki Yokoyama
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Activation of cardiac AMPK-FGF21 pathways during acute myocardial infarction2019

    • Author(s)
      Hiroaki Sunaga、Norimichi Koitabashi、Hiroki Matsui、Tatsuya Iso、Ryuichi Funada、Shu Kasama、Noriaki Takama、Takashi Nagasaka、Masami Murakami、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Serum Free Fatty Acid Composition as a Critical Regulator for Cardiac FGF21 Production in Patients with Acute Myocardial Infarction2019

    • Author(s)
      Hiroaki Sunaga、Norimichi Koitabashi、Hiroki Matsui、Tatsuya Iso、Ryuichi Funada、Shu Kasama、Noriaki Takama、Takashi Nagasaka、Masami Murakami、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fatty Acids as Central Fuels for Overloaded Hearts: Estimation of Catabolism and Anabolism in vivo Pressure-overloaded Hearts2019

    • Author(s)
      Tatsuya Iso、Yogi Umbarawan、Mas Rizky Syamsunarno、Hiroaki Sunaga、Hiroki Matsui、Norimichi Koitabashi、Masahiko Kurabayashi
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Deranged fatty acid composition by Elovl6 regulates cardiac inflammation and fibrosis after pressure overload in mice2019

    • Author(s)
      Sayaka Tadaki、Hiroki Matsui、Hiroaki Sunaga、Yogi Umbarawan、Nozomi Furukawa、Tatsuya Iso、Norimichi Koitabashi、Takashi Matsuzaka、Hitoshi Shimano、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] AMPK-KLF4 signaling activated by the change of intracellular FA composition regulates mitochondrial integrity2019

    • Author(s)
      Yurie Kon、Hiroki Matsui、Hiroaki Sunaga、Nozomi Furukawa、Tatsuya Iso、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DPP-4 inhibitor, Vildagliptin, induce FGF21 expression through AMPK-Sirt1 signaling in non-diabetic mice heart2019

    • Author(s)
      Nozomi Furukawa、Norimichi Koitabashi、Hiroaki Sunaga、Hiroki Matsui、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] FGF21は急性心筋梗塞における心筋代謝ストレスを示す新たなバイオマーカーである2018

    • Author(s)
      須永 浩章、小板橋 紀通、松井 弘樹、磯 達也、横山 知行、村上 正巳、倉林 正彦
    • Organizer
      第40回心筋生検研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Sacubitril/Valsartan Improves Passive Myocardial Stiffness via increased Titin Phosphorylation in Diabetic Mice2018

    • Author(s)
      Nozomi Furukawa、Norimichi Koitabashi、Hiroaki Sunaga、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      第35回国際心臓研究学会日本部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption2018

    • Author(s)
      Suman Shrestha、Tatsuya Iso、Hiroaki Sunaga、Masahiko Kurabayashi
    • Organizer
      第35回国際心臓研究学会日本部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Elevation of serum fibroblast growth factor 21 in patients with acute myocardial infarction: A potential role of AMPK activation following sympathetic overdrive2018

    • Author(s)
      Hiroaki Sunaga、Norimichi Koitabashi、Hiroki Matsui、Tatsuya Iso、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic deletion of Elovl6 in cardiac myocytes suppresses pressure overload-induced cardiac hypertrophy and remodeling through activation of AMPK-KLF4 signaling2018

    • Author(s)
      Hiroki Matsui、Hiroaki Sunaga、Yogi Umbarawan、Tatsuya Iso、Norimichi Koitabashi、Takashi Matsuzaka、Hitoshi Shimano、Tomoyuki Yokoyama、Masahiko Kurabayashi
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 急性心臓イベントの診断、重症度マーカーとしての線維芽細胞増殖因子FGF21の病態意義2018

    • Author(s)
      須永 浩章、松井 弘樹、小板橋 紀通、磯 達也、横山 知行、倉林 正彦
    • Organizer
      第25回日本未病システム学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂肪酸組成および脂肪酸伸長酵素Elovl6が心肥大・心不全の病態に及ぼす影響2018

    • Author(s)
      松井 弘樹、須永 浩章、Yogi Umbarawan、忠木 沙耶香、磯 達也、小板橋 紀通、松坂 賢、島野 仁、横山 知行、倉林 正彦
    • Organizer
      第25回日本未病システム学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Elovl6-driven fatty acid metabolism regulates hypertrophic response in the heart subjected to pressure overload in mice.2018

    • Author(s)
      Hiroaki Sunaga, Hiroki Matsui, Tatsuya Iso, Yogi Umbarawan, Takashi Matsuzaka, Hitoshi Shimano, Norimichi Koitabashi, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      第82回日本循環器学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibition of Fatty Acid Synthase Suppresses Vascular Smooth Muscle Cell Proliferation and Neointimal Formation: Potential Therapeutic Target in Atherosclerosis.2018

    • Author(s)
      Hiroki Matsui, Hiroaki Sunaga, Naomi Ohshima, Tatsuya Iso, Clay F. Semenkovich, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      第82回日本循環器学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification and molecular mechanisms of fibroblast growth factor 21 as a novel biomarker for metabolic stress in acute myocardial infarction.2018

    • Author(s)
      Norimichi Koitabashi, Hiroaki Sunaga, Hiroki Matsui, Tatsuya Iso, Masahiko Kurabayashi.
    • Organizer
      第82回日本循環器学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Circulating Ketone Body as a Novel Biomarker for Worse Clinical Outcomes in Hemodialysis Patients.2018

    • Author(s)
      Hiroaki Sunaga, Masaru Obokata, Kazuaki Negishi, Tetsuya Ogawa, Tatsuya Iso, Norimichi Koitabashi, Masahiko Kurabayashi.
    • Organizer
      第82回日本循環器学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂肪酸伸長酵素Elovl6により調節される脂肪酸代謝は圧負荷誘導性の心肥大を制御する2017

    • Author(s)
      須永 浩章, 松井 弘樹, 小板橋 紀通, 磯 達也, 松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
    • Organizer
      第21回日本心血管内分泌代謝学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Vildagliptin has a beneficial effect on myocardial energy metabolism through upregulation of FGF21 expression in pressure-overloaded mouse heart.2017

    • Author(s)
      Nozomi Furukawa, Norimichi Koitabashi, Hiroaki Sunaga, Masaru Obokata, Yogi, Rizky, Aiko Yamaguchi, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      第34回国際心臓研究学会日本部会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂肪酸合成酵素FASは血管平滑筋細胞の増殖と新生内膜肥厚の形成に重要である2017

    • Author(s)
      松井 弘樹, 須永 浩章, 大島 奈緒美, 磯 達也, 倉林 正彦,横山 知行
    • Organizer
      第25回日本血管生物医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 心不全マーカーとしての線維芽細胞増殖因子FGF21の有用性の評価2017

    • Author(s)
      須永 浩章, 松井 弘樹, 倉林 正彦
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺気腫病変にもたらす脂肪酸組成と調節酵素Elovl6の病態意義2017

    • Author(s)
      松井 弘樹, 須永 浩章, 倉林 正彦, 横山 知行
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 喫煙曝露の肺における脂肪酸組成およびElovl6の発現変化と病態意義2017

    • Author(s)
      松井 弘樹, 須永 浩章, 齊藤 美希, 前野 敏孝, 磯 達也, 倉林 正彦, 横山 知行
    • Organizer
      第24回日本未病システム学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂肪酸の量と質の変化から未病を考える2017

    • Author(s)
      松井 弘樹, 須永 浩章, 上野 学, 小板橋 紀通, 前野 敏孝,磯 達也,松坂 賢, 島野 仁, 倉林 正彦, 横山 知行
    • Organizer
      第57回日本臨床化学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺線維症・肺気腫の発症における脂質バランス異常の意義2017

    • Author(s)
      松井 弘樹, 須永 浩章, 上野 学, 前野 敏孝,磯 達也,松坂 賢, 島野 仁, 倉林 正彦, 横山 知行
    • Organizer
      第53回サーファクタント関連医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Soluble Isoforms of ST2 and Galectin-3 Have Independent and Incremental Prognostic Value in Chronic Hemodialysis Patients2017

    • Author(s)
      Hiroaki Sunaga, Masaru Obokata, Tetsuya Ogawa, Kazuaki Negishi, Masahiko Kurabayashi
    • Organizer
      第81回日本循環器学会総会・学術集会
    • Place of Presentation
      金沢
    • Related Report
      2016 Research-status Report
  • [Presentation] Vildagliptin Improves Ventricular Efficiency in Non-diabetic Pressure-overloaded Mouse Heart2017

    • Author(s)
      Nozomi Furukawa, Norimichi Koitabashi, Hiroaki Sunaga, Masaru Obokata, Yogi Umbarawan, Aiko Yamaguchi, Mas Rizky A.A Syamsunarno,Tatsuya Iso, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      第81回日本循環器学会総会・学術集会
    • Place of Presentation
      金沢
    • Related Report
      2016 Research-status Report
  • [Presentation] CD36 plays a crucial role in exercise endurance during prolonged fasting in mice2017

    • Author(s)
      Hikari Haruyama, Tatsuya Iso, Hiroaki Sunaga, Yogi Umbarawan, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      第81回日本循環器学会総会・学術集会
    • Place of Presentation
      金沢
    • Related Report
      2016 Research-status Report
  • [Presentation] Genetic deletion of fatty acid synthase in vascular smooth muscle cell suppresses injury-induced neointima formation in mice2017

    • Author(s)
      Naomi Oshima, Hiroki Matsui, Hiroaki Sunaga, Tatsuya Iso, Clay F. Semenkovich, Masahiko Kurabayashi, Tomoyuki Yokoyama
    • Organizer
      第81回日本循環器学会総会・学術集会
    • Place of Presentation
      金沢
    • Related Report
      2016 Research-status Report
  • [Presentation] Inhibition of fatty acid synthase plays a protective role in vascular smooth muscle cell proliferation and neointimal formation2016

    • Author(s)
      Hiroki Matsui, Hiroaki Sunaga, Tatsuya Iso, Norimichi Koitabashi, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      American Heart Association Scientific Session 2016 (国際学会)
    • Place of Presentation
      アメリカ (ニューオーリンズ)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A massive increase in serum levels of fatty acid binding protein 4 in patients with acute myocardial infarction complicated by out-of-hospital cardiac arrest due to ventricular fibrillation2016

    • Author(s)
      Hiroaki Sunaga, Tatsuya Iso, Masaru Obokata, Yoshiaki Ohyama, Norimichi Koitabashi, Ryuichi Funada, Noriaki Takama, Hiroki Matsui, Tomoyuki Yokoyama, Masami Murakami, Masahiko Kurabayashi
    • Organizer
      American Heart Association Scientific Session 2016 (国際学会)
    • Place of Presentation
      アメリカ (ニューオーリンズ)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Soluble isoforms of ST2 and galectin-3 have independent and incremental prognostic value in patients with hemodialysis2016

    • Author(s)
      Hiroaki Sunaga, Masaru Obokata, Hideki Ishida, Kyoko Ito, Tetsuya Ogawa, Yoshitaka Ando, Kazuaki Negishi, Masahiko Kurabayashi
    • Organizer
      American Heart Association Scientific Session 2016 (国際学会)
    • Place of Presentation
      アメリカ (ニューオーリンズ)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Vildagliptin Attenuates Cardiac Hypertrophy and Improves Ventricular Efficiency through FGF21 Expression in Pressure-overloaded Mouse Heart2016

    • Author(s)
      Nozomi Furukawa, Norimichi Koitabashi, Hiroaki Sunaga, Masaru Obokata, Yogi, Rizky, Aiko Yamaguchi, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      American Heart Association Scientific Session 2016 (国際学会)
    • Place of Presentation
      アメリカ (ニューオーリンズ)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] CD36 plays a crucial role in exercise endurance during prolonged fasting in mice2016

    • Author(s)
      Hikari Haruyama, Tatsuya Iso, Hiroaki Sunaga, Yogi Umbarawan, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      American Heart Association Scientific Session 2016 (国際学会)
    • Place of Presentation
      アメリカ (ニューオーリンズ)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] AMPK-KLF4経路の活性化が血管平滑筋細胞の形質転換と増殖に及ぼす影響の解明2016

    • Author(s)
      須永 浩章, 松井 弘樹, 小板橋 紀通, 磯 達也, 松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
    • Organizer
      第48回日本動脈硬化学会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] 新規心臓線維化バイオマーカーは維持透析患者の心血管イベントリスク層別化に有用である2016

    • Author(s)
      須永 浩章, 小保方 優, 根岸 一明, 石田 秀岐, 伊藤 恭子, 小川 哲也, 安藤 義孝, 松井 弘樹, 横山 知行, 倉林 正彦
    • Organizer
      第23回日本未病システム学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2016 Research-status Report
  • [Presentation] 脂肪酸合成酵素FASは動脈硬化の初期病変である新生内膜肥厚の形成に重要である2016

    • Author(s)
      松井 弘樹, 須永 浩章、大島 奈緒美、春山 光、古川 希、磯 達也、倉林 正彦、横山 知行
    • Organizer
      第23回日本未病システム学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2016 Research-status Report
  • [Presentation] コーヒーおよびカフェインの摂取が血流依存性血管拡張反応(FMD)に及ぼす影響2016

    • Author(s)
      松井 弘樹, 古川 希、大島 奈緒美、須永 浩章、横山 知行
    • Organizer
      第23回日本未病システム学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2016 Research-status Report
  • [Book] 分子呼吸器病2017

    • Author(s)
      須永 浩章, 松井 弘樹, 前野 敏孝, 原 健一郎, 上野 学, 増渕 裕朗, 磯 達也, 小板橋 紀通, 松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
    • Total Pages
      4
    • Publisher
      先端医学社
    • ISBN
      9784865502503
    • Related Report
      2017 Research-status Report
  • [Remarks] 群馬大学大学院医学系研究科 循環器内科学

    • URL

      http://gunma-u-med2.jp

    • Related Report
      2018 Annual Research Report
  • [Remarks] 群馬大学大学院保健学研究科 生体情報検査科学講座 横山・松井研究室

    • URL

      http://heart.health.gunma-u.ac.jp

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Remarks] 群馬大学大学院保健学研究科 生体情報検査科学講座 横山・松井研究室

    • URL

      http://heart.health.gunma-u.ac.jp

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi