Development of novel treatment for severe obesity asthma

• Project/Area Number: 16K19448
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUZUKI YUZO 浜松医科大学, 医学部, 助教 (00758435)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肥満喘息 / 重症喘息 / オートファジー / アレルギー / 気管支喘息 / 肥満 / 喘息

Outline of Final Research Achievements

Close associations between obesity and severe asthma have epidemiologically reported. However, little is known about underlying mechanism. We investigated the pathogenesis of autophagy in development of severe obesity induced asthma. We found that high-fat diet induced autophagy deficient obesity mice (Atg5-/- obesity mice) developed severe asthma in terms of elevated eosinophilic inflammation together with increased airway hyperreactivity (AHR). Furthermore, increased eosinophil inflammation and AHR in Atg5-/- obesity mice was TSLP dependent. Our results showed autophagy is involved in the pathogenesis of obesity induced severe eosinophilic asthma and can be a novel therapy target for these patients.

Academic Significance and Societal Importance of the Research Achievements

肥満喘息の難治化の要因を、生体の恒常性維持に必須であるオートファジーに注目して解析した。本研究ではオートファジー低下によってもたらされる気道上皮関連サイトカイン：TSLP上昇が病因に関与すると考えられた。成人肥満の増加のみならず小児肥満の増加も報告され、肥満による喘息コントロールの難治化、重症化がは今後の喘息診療の大きな課題になると考えられる。そのため、本研究で得られた知見は非常に重要である。さらに、オートファジー制御は重症肥満喘息の新規治療標的の候補になると考えられた。

Research Products

• [Journal Article] Successful classification of macrophage-mannose receptor CD206 in severity of anti-MDA5 antibody positive dermatomyositis associated ILD (2019)
  • Author(s): Horiike Yasuoki, Suzuki Yuzo, Fujisawa Tomoyuki, Yasui Hideki, Karayama, Masato, Hozumi Hironao, Furuhashi Kazuki, Enomoto Noriyuki, Nakamura Yutaro, Inui Naoki, Ogawa Noriyoshi, Suda Takafumi
  • Journal Title: Rheumatology Volume: 印刷中 Issue: 12 Pages: 2143-2152
  • DOI: 10.1093/rheumatology/kez185
  • Peer Reviewed
• [Journal Article] Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion. (2019)
  • Author(s): Fujisawa T, Mori K, Mikamo M, Ohno T, Kataoka K, Sugimoto C, Kitamura H, Enomoto N, Egashira R, Sumikawa H, Iwasawa T, Matsushita S, Sugiura H, Hashisako M, Tanaka T, Terasaki Y, Kunugi S, Kitani M, Okuda R, Horiike Y, Enomoto Y, Yasui H, Hozumi H, Suzuki Y, Nakamura Y, Fukuoka J, Johkoh T, Kondoh Y, Ogura T,,, Suda T.
  • Journal Title: Eur Respir J. Volume: 3 Issue: 5 Pages: 1802243-1802243
  • DOI: 10.1183/13993003.02243-2018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of corticosteroid and intravenous cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: A propensity score‐matched analysis (2019)
  • Author(s): Hozumi Hironao、Hasegawa Hirotsugu、Miyashita Koichi、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Hashimoto Dai、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Yokomura Koshi、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respirology Volume: 印刷中 Issue: 8 Pages: 792-798
  • DOI: 10.1111/resp.13506
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Switch maintenance therapy with S-1 after induction therapy with carboplatin and nanoparticle albumin-bound paclitaxel in advanced lung squamous cell carcinoma (2019)
  • Author(s): Akiyama Norimichi、Karayama Masato、Inui Naoki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inami Nao、Matsuura Shun、Kaida Yusuke、Uto Tomohiro、Matsui Takashi、Asada Kazuhiro、Matsuda Hiroyuki、Fujii Masato、Toyoshima Mikio、Suda Takafumi
  • Journal Title: Investigational New Drugs Volume: 印刷中 Issue: 3 Pages: 531-537
  • DOI: 10.1007/s10637-019-00747-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correlation of the modified Medical Research Council dyspnea scale with airway structure assessed by three-dimensional CT in patients with chronic obstructive pulmonary disease (2019)
  • Author(s): Yasui Hideki、Inui Naoki、Karayama Masato、Mori Kazutaka、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Watanabe Hiroshi、Suda Takafumi
  • Journal Title: Respiratory Medicine Volume: 146 Pages: 76-80
  • DOI: 10.1016/j.rmed.2018.11.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy of Glucocorticoids and Calcineurin Inhibitors for Anti-aminoacyl-tRNA Synthetase Antibody?positive Polymyositis/dermatomyositis?associated Interstitial Lung Disease: A Propensity Score?matched Analysis (2019)
  • Author(s): Hozumi Hironao、Fujisawa Tomoyuki、Nakashima Ran、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Inui Naoki、Nakamura Yutaro、Mimori Tsuneyo、Suda Takafumi
  • Journal Title: The Journal of Rheumatology Volume: 印刷中 Issue: 5 Pages: 509-517
  • DOI: 10.3899/jrheum.180778
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Methotrexate-associated Lymphoproliferative Disorder with Diffuse Ground-Glass Opacities (2019)
  • Author(s): Tsuchiya Kazuo、Suzuki Yuzo、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Baba Satoshi、Suda Takafumi
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 199 Issue: 8 Pages: 1031-1033
  • DOI: 10.1164/rccm.201806-1115im
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An Acquired Epidermal Growth Factor Receptor T790M Mutation after the Addition of Bevacizumab to Preceding Erlotinib Monotherapy in a Lung Cancer Patient with Leptomeningeal Metastases (2018)
  • Author(s): Tsuchiya Kazuo、Karayama Masato、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Internal Medicine Volume: 57 Issue: 23 Pages: 3423-3427
  • DOI: 10.2169/internalmedicine.1062-18
  • NAID: 130007539653
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-12-01
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differences in clinical features of acute exacerbation between connective tissue disease-associated interstitial pneumonia and idiopathic pulmonary fibrosis (2018)
  • Author(s): Enomoto Noriyuki、Oyama Yoshiyuki、Enomoto Yasunori、Yasui Hideki、Karayama Masato、Kono Masato、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: Chronic Respiratory Disease Volume: 16
  • DOI: 10.1177/1479972318809476
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis (2018)
  • Author(s): Suzuki Yuzo、Yoshimura Katsuhiro、Enomoto Yasunori、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 14074-14074
  • DOI: 10.1038/s41598-018-32478-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-17A Attenuates IFN-λ Expression by Inducing Suppressor of Cytokine Signaling Expression in Airway Epithelium (2018)
  • Author(s): Niwa Mitsuru、Fujisawa Tomoyuki、Mori Kazutaka、Yamanaka Katsumasa、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suzuki Tetsuro、Maekawa Masato、Suda Takafumi
  • Journal Title: The Journal of Immunology Volume: 201 Issue: 8 Pages: 2392-2402
  • DOI: 10.4049/jimmunol.1800147
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prophylactic aprepitant is better than salvage for carboplatin-based chemotherapy: a propensity score-matched analysis (2018)
  • Author(s): Karayama Masato、Inui Naoki、Tanaka Kazuki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: Medical Oncology Volume: 35 Issue: 11 Pages: 139-139
  • DOI: 10.1007/s12032-018-1199-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis (2018)
  • Author(s): Suzuki Yuzo、Shirai Masahiro、Asada Kazuhiro、Yasui Hideki、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Shirai Toshihiro、Hayakawa Hiroshi、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 13129-13129
  • DOI: 10.1038/s41598-018-31565-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differences in airway structural changes assessed by 3-dimensional computed tomography in asthma and asthma?chronic obstructive pulmonary disease overlap (2018)
  • Author(s): Niwa Mitsuru、Fujisawa Tomoyuki、Karayama Masato、Furuhashi Kazuki、Mori Kazutaka、Hashimoto Dai、Yasui Hideki、Suzuki Yuzo、Hozumi Hironao、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Annals of Allergy, Asthma & Immunology Volume: 121 Issue: 6 Pages: 704-710.e1
  • DOI: 10.1016/j.anai.2018.08.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Changes in pulmonary endothelial cell properties during bleomycin-induced pulmonary fibrosis. (2018)
  • Author(s): Kato S, Inui N*, Hakamata A, Suzuki Y, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
  • Journal Title: Respir Res. Volume: 19 Issue: 1 Pages: 127-127
  • DOI: 10.1186/s12931-018-0831-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical significance of myeloperoxidase-anti-neutrophil cytoplasmic antibody in idiopathic interstitial pneumonias (2018)
  • Author(s): Hozumi Hironao、Oyama Yoshiyuki、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: PLOS ONE Volume: 13 Issue: 6 Pages: e0199659-e0199659
  • DOI: 10.1371/journal.pone.0199659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Switch maintenance therapy with docetaxel and bevacizumab after induction therapy with cisplatin, pemetrexed, and bevacizumab in advanced non-squamous non-small cell lung cancer: a phase II study (2018)
  • Author(s): Nishimoto Koji、Karayama Masato、Inui Naoki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inami Nao、Matsuura Shun、Kaida Yusuke、Matsui Takashi、Asada Kazuhiro、Matsuda Hiroyuki、Fujii Masato、Toyoshima Mikio、Imokawa Shiro、Suda Takafumi
  • Journal Title: Medical Oncology Volume: 35 Issue: 7 Pages: 108-108
  • DOI: 10.1007/s12032-018-1172-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic evaluation of serum ferritin in acute exacerbation of idiopathic pulmonary fibrosis (2018)
  • Author(s): Enomoto Noriyuki、Oyama Yoshiyuki、Enomoto Yasunori、Mikamo Masashi、Karayama Masato、Hozumi Hironao、Suzuki Yuzo、Kono Masato、Furuhashi Kazuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: The Clinical Respiratory Journal Volume: 12 Issue: 8 Pages: 2378-2389
  • DOI: 10.1111/crj.12918
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Utility of serum Aspergillus-galactomannan antigen to evaluate the risk of severe acute exacerbation in chronic obstructive pulmonary disease (2018)
  • Author(s): Yoshimura Katsuhiro、Suzuki Yuzo、Inoue Yusuke、Nishimoto Koji、Mori Kazutaka、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Yokomura Koushi、Imokawa Shiro、Suda Takafumi
  • Journal Title: PLOS ONE Volume: 13 Issue: 6 Pages: e0198479-e0198479
  • DOI: 10.1371/journal.pone.0198479
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinctive characteristics and prognostic significance of interstitial pneumonia with autoimmune features in patients with chronic fibrosing interstitial pneumonia. (2018)
  • Author(s): Yoshimura K, Kono M, Enomoto Y, Nishimoto K, Oyama Y, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Sumikawa H, Johkoh T, Colby TV, Sugimura H, Suda T.
  • Journal Title: Respiratory Medicine Volume: 137 Pages: 167-175
  • DOI: 10.1016/j.rmed.2018.02.024
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long-term management and persistent impairment of pulmonary function in chronic eosinophilic pneumonia: A review of the previous literature (2018)
  • Author(s): Suzuki Y, Suda T.
  • Journal Title: Allergology International Volume: 67 Issue: 3 Pages: 334-340
  • DOI: 10.1016/j.alit.2017.12.004
  • NAID: 130007420931
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Neutrophil gelatinase-associated lipocalin in patients with sarcoidosis. (2018)
  • Author(s): Kato S, Inui N, Hozumi H, Inoue Y, Yasui H, Karayama M, Kono M, Suzuki Y, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
  • Journal Title: Respiratory Medicine Volume: 印刷中 Pages: S20-S23
  • DOI: 10.1016/j.rmed.2018.01.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Respiratory impedance is correlated with airway narrowing in asthma using three-dimensional computed tomography (2018)
  • Author(s): Karayama M, Inui N, Mori K, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
  • Journal Title: Clin Exp Allergy Volume: 48 Issue: 3 Pages: 278-287
  • DOI: 10.1111/cea.13083
  • Peer Reviewed
• [Journal Article] Body size-adjusted dose analysis of pirfenidone in patients with interstitial pneumonia. (2018)
  • Author(s): Uehara M, Enomoto N, Oyama Y, Suzuki Y, Kono M, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Respirology Volume: 23 Issue: 3 Pages: 318-318
  • DOI: 10.1111/resp.13145
  • Peer Reviewed
• [Journal Article] Clinical diagnosis of idiopathic pleuroparenchymal fibroelastosis: A retrospective multicenter study. (2017)
  • Author(s): Enomoto Y, Nakamura Y, Satake Y, Sumikawa H, Johkoh T, Colby TV, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Inui N, Iwashita T, Kuroishi S, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Yamada T, Shirai T, Hayakawa H, Suda T.
  • Journal Title: Respir Med. Volume: 133 Pages: 1-5
  • DOI: 10.1016/j.rmed.2017.11.003
  • Peer Reviewed
• [Journal Article] Persistent impairment on spirometry in chronic eosinophilic pneumonia: a longitudinal observation study (Shizuoka-CEP study) (2017)
  • Author(s): Suzuki Y, Oyama Y, Hozumi H, Imokawa S, Toyoshima M, Yokomura K, Nakamura H, Kuroishi S, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Koshimizu N, Yamada T, Mori K, Masuda M, Shirai T, Hayakawa H, Sumikawa M, Johkoh T, Suda T
  • Journal Title: Ann Allergy Asthma Immunol Volume: 119 Issue: 5 Pages: 422-428
  • DOI: 10.1016/j.anai.2017.08.009
  • Peer Reviewed
• [Journal Article] Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma (2017)
  • Author(s): Nishimoto K, Karayama M, Inui N, Mori K, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 10187-10187
  • DOI: 10.1038/s41598-017-10504-w
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Utility of YKL-40 in Polymyositis/dermatomyositis-associated Interstitial Lung Disease (2017)
  • Author(s): Hozumi H, Fujisawa T, Enomoto N, Nakashima R, Enomoto Y, Suzuki Y, Kono M, Karayama M, Furuhashi K, Murakami A, Inui N, Nakamura Y, Mimori T, Suda T
  • Journal Title: J Rheumatol Volume: 44 Issue: 9 Pages: 1394-1401
  • DOI: 10.3899/jrheum.170373
  • Peer Reviewed
• [Journal Article] Respiratory impedance is correlated with morphological changes in the lungs on three-dimensional CT in patients with COPD. (2017)
  • Author(s): Karayama M, Inui N, Mori K, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 41709-41709
  • DOI: 10.1038/srep41709
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of urinary desmosines as a noninvasive diagnostic biomarker in patients with idiopathic pleuroparenchymal fibroelastosis (PPFE). (2017)
  • Author(s): Oyama Y, Enomoto N, Suzuki Y, Kono M, Fujisawa T, Inui N, Nakamura Y, Kuroishi S, Yokomura K, Toyoshima M, Imokawa S, Oishi K, Watanabe S, Kasahara K, Baba T, Ogura T, Ishii H, Watanabe K, Nishioka Y, Suda T.
  • Journal Title: Respiratory Medicine Volume: 123 Pages: 63-70
  • DOI: 10.1016/j.rmed.2016.12.013
  • Peer Reviewed
• [Journal Article] Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease (2017)
  • Author(s): Enomoto Y, Suzuki Y, Hozumi H, Mori K, Kono M, Karayama M, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suzuki D, Ogawa N, Nakashima R, Mimori T, Iwashita T, Suda T
  • Journal Title: Arthritis Res Ther Volume: 19 Issue: 1 Pages: 9-9
  • DOI: 10.1186/s13075-016-1214-8
  • NAID: 120005973333
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reply. (2017)
  • Author(s): Maazi H, Suzuki Y, Jung J, Akbari O
  • Journal Title: Journal of Allergy & Clinical Immunology Volume: 2 Issue: 2 Pages: 712-713
  • DOI: 10.1016/j.jaci.2016.06.067
  • Peer Reviewed
• [Journal Article] Utility of Macrophage-activated Marker CD163 for Diagnosis and Prognosis in Pulmonary Tuberculosis. (2017)
  • Author(s): Suzuki Y, Shirai M, Asada K, Miwa S, Karayama M, Nakamura Y, Inui N, Shirai T, Hayakawa H, Baba S, Suda T
  • Journal Title: Ann Am Thorac Soc Volume: 14 Issue: 1 Pages: 57-64
  • DOI: 10.1513/annalsats.201607-528oc
  • Peer Reviewed
• [Journal Article] Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity. (2016)
  • Author(s): Galle-Treger L, Suzuki Y, Patel N, Sankaranarayanan I, Aron JL, Maazi H, Chen L, Akbari O
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 13202-13202
  • DOI: 10.1038/ncomms13202
  • Peer Reviewed / Open Access
• [Journal Article] Soluble hemoglobin scavenger receptor CD163 (sCD163) predicts mortality of community-acquired pneumonia (2016)
  • Author(s): Suzuki Y, Enomoto Y, Yokomura K, Hozumi H, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T
  • Journal Title: J Infect Volume: 73 Issue: 4 Pages: 375-377
  • DOI: 10.1016/j.jinf.2016.07.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Morphological changes in small pulmonary vessels are associated with severe acute exacerbation in chronic obstructive pulmonary disease. (2016)
  • Author(s): Yoshimura K, Suzuki Y, Uto T, Sato J, Imokawa S, Suda T
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: 11 Pages: 1435-55
  • DOI: 10.2147/copd.s107424
  • Peer Reviewed / Open Access
• [Journal Article] Gastrointestinal Bleeding From Duodenal Aberrant Pancreas After Antiangiogenic Therapy. (2016)
  • Author(s): Nishimoto K, Karayama M, Akiyama N, Suzuki S, Inoue Y, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T
  • Journal Title: Journal of Clinical Gastroenterology Volume: 8 Issue: 8 Pages: 689-690
  • DOI: 10.1097/mcg.0000000000000561
  • Peer Reviewed
• [Presentation] PD-1 Immune Checkpoint Inhibitor Alters Airway Inflammation and Pulmonary Function: A Prospective Study (2018)
  • Author(s): Yuzo Suzuki
  • Organizer: American Thoracic Society International Conference 2018
  • Int'l Joint Research
• [Presentation] 抗PD-1抗体が気道炎症および肺機能に与える影響 (2018)
  • Author(s): 鈴木勇三
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] 抗PD-1抗体が気道炎症および肺機能に与える影響 (2018)
  • Author(s): 鈴木勇三
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] Distinct regulations of CD163+ macrophages and indoleamine 2,3-dioxygenase in lung cancer and infectious disease (2017)
  • Author(s): Yuzo Suzuki
  • Organizer: American Thoracic Society
  • Int'l Joint Research
• [Presentation] 慢性好酸球性肺炎の長期予後の検討 （多施設共同研究） (2016)
  • Author(s): 鈴木 勇三, 妹川 史朗, 豊嶋 幹生, 横村 光司, 中村 秀範, 黒石 重城, 乾 直輝, 中村 祐太郎, 小清水 直樹, 山田 孝, 白井 敏博, 増田 昌文, 早川 啓史, 須田 隆文
  • Organizer: 日本アレルギー学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-17
• [Presentation] Long-term Outcome and Prognostic Factors of Chronic Eosinophilic Pneumonia: Fujiyama Cohort Study (2016)
  • Author(s): Yuzo Suzuki,Imokawa S, Mikio Toyoshima M, Yokomura K, Nakamura H, Kuroishi S, Koshimizu N, Yamada T, Shirai T, Masuda M, Hiroshi Ha H, Suda T
  • Organizer: American Thoracic Society Annual Meeting 2016
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] 慢性好酸球性肺炎の長期予後の検討 （多施設共同研究） (2016)
  • Author(s): 鈴木 勇三, 妹川 史朗, 豊嶋 幹生, 横村 光司, 中村 秀範, 黒石 重城, 乾 直輝, 中村 祐太郎, 小清水 直樹, 山田 孝, 増田 昌文, 白井 敏博, 早川 啓史, 須田 隆文
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2016-04-08