Role of adiponectin in the pathogenesis of pulmonary fibrosis

• Project/Area Number: 16K19451
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka University
• Principal Investigator: Kuroyama Muneyoshi 大阪大学, 医学系研究科, 特任助教(常勤) (50770830)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アディポネクチン / 肺線維症 / 肺気腫

Outline of Final Research Achievements

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by progressive and irreversible scarring of the lung. However, the pathogenesis of IPF is not completely understood and current therapies are limited to those that reduce the rate of functional decline in patients with mild-to-moderate disease. Accumulating evidence suggests adiponectin (APN) may be a promising therapy against fibrotic diseases. Here, we determine whether　APN protects against pulmonary fibrosis in bleomycin-induced mice

Research Products

• [Journal Article] Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging (2018)
  • Author(s): Jin Y, Takeda Y, Kondo Y, Tripathi LP, Kang S, Takeshita H, Kuhara H, Maeda Y, Higashiguchi M, Miyake K, Morimura O、Koba T、Hayama Y、Koyama S、Nakanishi K、Iwasaki T、Tetsumoto Si、Tsujino K、Kuroyama M、Iwahori K、Hirata H、Takimoto Ti、Suzuki M、Nagatomo I、Sugimoto K、Fujii Y、Kida H、et al.
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 5145-5145
  • DOI: 10.1038/s41598-018-23338-x
  • Peer Reviewed / Open Access
• [Journal Article] Rapid intracranial response to osimertinib, without radiotherapy, in nonsmall cell lung cancer patients harboring the EGFR T790M mutation: Two Case Reports (2017)
  • Author(s): Koba T, Kijima T, Takimoto T, Hirata H, Naito Y, Hamaguchi M, Otsuka T, Kuroyama M, Nagatomo I, Takeda Y, Kida H, Kumanogoh A
  • Journal Title: Medicine (Baltimore) Volume: 96 Issue: 6 Pages: 6087-6087
  • DOI: 10.1097/md.0000000000006087
  • Peer Reviewed / Open Access
• [Presentation] エクソソームの最新プロテオミクスによるCOPD・喘息の新規バイオマーカー探索 (2017)
  • Author(s): 玄山宗到、武田吉人、葉山善友、滝本宣之、木島貴志、熊ノ郷 淳、植田幸嗣
  • Organizer: 骨免疫学会
• [Presentation] エクソソームの最新プロテオミクスによるCOPD・喘息の新規バイオマーカー探索 (2017)
  • Author(s): 玄山宗到、武田吉人、葉山善友、滝本宣之、木島貴志、熊ノ郷 淳、植田幸嗣
  • Organizer: 呼吸器学会総会
• [Book] 最新医学 (2016)
  • Author(s): 玄山宗到、武田吉人
  • Total Pages: 8
  • Publisher: 最新医学社
• [Book] 呼吸と循環 (2016)
  • Author(s): 玄山宗到、平田陽彦、武田吉人
  • Total Pages: 7
  • Publisher: 医学書院
• [Book] Respiratory Trends (2016)
  • Author(s): 中西香織、玄山宗到、武田吉人
  • Total Pages: 6
  • Publisher: メディカルレビュー社