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Investigation of a role of bone marrow-derived fibrocytes in lung cancer progression

Research Project

Project/Area Number 16K19456
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

SAIJO Atsuro  徳島大学, 大学院医歯薬学研究部(医学系), 特任助教 (00467812)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsがん幹細胞 / 肺がん / 線維細胞 / 肺癌 / 腫瘍微小環境 / 癌
Outline of Final Research Achievements

This study aimed to clarify a role of fibrocytes in lung cancer progression. Human fibrocytes enhanced the CSC-like properties of lung cancer cells through secreted factors, including osteopontin, CC-chemokine ligand 18, and plasminogen activator inhibitor-1. The PIK3K/AKT pathway was critical for fibrocytes to mediate the CSC-like functions of lung cancer cells. In human lung cancer specimens, the number of tumor-infiltrated fibrocytes was correlated with high expression of CSC-associated protein in cancer cells. These results suggest that fibrocytes may be a novel cell population that regulates the CSC-like properties of lung cancer cells in the CSC niches.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells.2018

    • Author(s)
      Saijo A, Goto H, Nakano M, Mitsuhashi A, Aono Y, Hanibuchi M, Ogawa H, Uehara H, Kondo K, Nishioka Y
    • Journal Title

      Cancer Lett

      Volume: 421 Pages: 17-27

    • DOI

      10.1016/j.canlet.2018.02.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells2017

    • Author(s)
      Atsuro Saijo, Hisatsugu Goto, Mayuri Nakano, Atsushi Mitsuhashi, Hirokazu Ogino, Makoto Tobiume, Kenji Otsuka, Hiroto Yoneda, Masaki Hanibuchi, Yasuhiko Nishioka
    • Organizer
      ATS 2017 International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨髄由来線維細胞(fibrocyte)は肺癌のがん幹細胞様特性を促進する2017

    • Author(s)
      西條敦郎、後東久嗣、荻野広和、軒原浩、西岡安彦
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells2017

    • Author(s)
      Atsuro Saijo, Hisatsugu Goto, Mayuri Nakano, Atsushi Mitsuhashi, Hirokazu Ogino, Makoto Tobiume, Kenji Otsuka, Hiroto Yoneda, Masaki Hanibuchi, Yasuhiko Nishioka
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨髄由来線維細胞(fibrocyte)は肺癌のがん幹細胞様特性を促進する2016

    • Author(s)
      西條敦郎
    • Organizer
      第25回日本がん転移学会学術集会・総会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Bone-marrow derived fibrocytes maintain stem cell-like properties of lung cancer2016

    • Author(s)
      Atsuro Saijo
    • Organizer
      ATS 2016 International Conference
    • Place of Presentation
      San Francisco (United States of America)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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