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Investigation of the common RNA networks in lung cancer and idiopathic pulmonary fibrosis for the new strategy of the diseases.

Research Project

Project/Area Number 16K19458
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionKagoshima University

Principal Investigator

MATAKI Hiroko  鹿児島大学, 附属病院, 医員 (60750750)

Co-Investigator(Renkei-kenkyūsha) Seki Naohiko  千葉大学, 大学院医学研究院, 准教授 (50345013)
Research Collaborator Inoue Hiromasa  鹿児島大学, 医歯学域医学系, 教授 (30264039)
Mizuno Keiko  鹿児島大学, 医歯学域医学系, 助教 (50531414)
Kumamoto Tomohiro  鹿児島大学, 附属病院, 特任助教 (20622517)
Kamikawaji Kazuto  鹿児島大学, 附属病院, 医員 (80633396)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsmicroRNA / 肺癌 / 特発性肺線維症 / 核酸 / マイクロRNA / 肺線維症
Outline of Final Research Achievements

Idiopathic pulmonary fibrosis (IPF) is frequently associated with lung cancer. However, the curative treatment has not been developed for the disease. We investigated novel RNA networks mediated by miRNAs, and identified the molecular targets involved in the pathology of the disease.
We confirmed the downregulation of miR-29a in clinical specimens of IPF and lung cancer. Restoration of miR-29a suppressed cancer cell aggressiveness and fibroblast migration. A combination of gene expression data and in silico analysis showed that lysyl oxidase-like 2 (LOXL2) and serpin peptidase inhibitor clade H, member 1 (SERPINH1) were direct targets of miR-29a, suggesting that these genes are involved in the pathogenesis of these two diseases.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes2017

    • Author(s)
      Mizuno Keiko、Mataki Hiroko、Arai Takayuki、Okato Atsushi、Kamikawaji Kazuto、Kumamoto Tomohiro、Hiraki Tsubasa、Hatanaka Kazuhito、Inoue Hiromasa、Seki Naohiko
    • Journal Title

      Journal of Human Genetics

      Volume: 62 Issue: 7 Pages: 671-678

    • DOI

      10.1038/jhg.2017.27

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.2016

    • Author(s)
      Kamikawaji K, Seki N, Watanabe M, Mataki H, Kumamoto T, Takagi K, Mizuno K, Inoue H.
    • Journal Title

      J Hum GenetJ Hum Genet.

      Volume: 12 Pages: 985-993

    • NAID

      40021022822

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C2017

    • Author(s)
      俣木 浩子
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 特発性肺線維症合併肺癌における腫瘍抑制性microRNA-29aに関する検討2016

    • Author(s)
      上川路和人
    • Organizer
      日本肺癌学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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