| Project/Area Number |
16K19460
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Saito Atsushi 札幌医科大学, 医学部, 助教 (00768939)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肺胞微石症 / 動物モデル / ナトリウムリン酸共輸送体 / 治療法開発 / 肺胞マクロファージ / 肺サーファクタント / マウスモデル / 低リン食治療法 / リン吸着剤 / 低リン食治療 |
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| Outline of Final Research Achievements |
There was no effective treatment for alveolar microlithiasis. So we tried to developing the treatment strategies using our animal model in this research. LPD prevents progressive microlith accumulation in young Npt2b-/- mice and reverses stone burden in Npt2b-/- mice. On the other hands, there was a little side effect with this treatment. Additionally, Tomocube 3D microscope revealed that microlithes were present in alveolar macrophages from Npt2b-/- mice. Alveolar macrophage seems to play an important role in the metabolism of calcium phosphate microlithes.
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