Elucidation of pharmacokinetics of molecular targeted drugs by Imaging massspectrometry
Project/Area Number |
16K19465
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | Keio University |
Principal Investigator |
|
Research Collaborator |
SOEJIMA Kenzo
YASUDA Hiroyuki
MASUZAWA Keita
ARAI Daisuke
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 肺癌 / 分子標的薬 / 腫瘍内代謝 / imaging massspectrometry / 血管新生阻害薬 |
Outline of Final Research Achievements |
We established a xenograft mouse model subcutaneously transplanted with a non-small cell lung cancer cell line. Next, we evaluated Intratumoral metabolism of xenograft mouse model using imaging massspectrometry after administration of angiogenesis inhibitor (BIBF 1120, bevacizumab). As a result of evaluation, BIBF 1120 and bevacizumab showed different effects on blood flow and intratumoral metabolism.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors.2017
Author(s)
Nukaga S, Yasuda H, Tsuchihara K, Hamamoto J, Masuzawa K, Kawada I, Naoki K, Matsumoto S, Mimaki S, Ikemura S, Goto K, Betsuyaku T, Soejima K.
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Journal Title
Cancer Research
Volume: 77(8)
Issue: 8
Pages: 2078-2089
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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