The contribution of a novel epithelial-derived cytokine to the host defense against pneumococcal pneumonia

Research Project

Project/Area Number	16K19466
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Respiratory organ internal medicine
Research Institution	Keio University
Principal Investigator	Kamata Hirofumi 慶應義塾大学, 医学部(信濃町), 助教 (60528545)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	肺炎球菌肺炎 / Sectm1a / 肺炎球菌 / Sectm1aノックアウトマウス / 気道上皮細胞
Outline of Final Research Achievements	We purchased Sectm1a KO sperm from University California, Davis（UC Davis）and created Sectm1a hetero KO mice in RIKEN TSUKUBA Campus followed by crossing them in our faclity. We succeeded in breeding Sectm1a KO mice stably in our facility. To the best of our knowledge, there has been no report in which Sectm1a KO mice were used and thus our preset study could provide novel insights to further elucidate the mechanisms through which host immune sytem works during pneuococcal pneumonia.