| Project/Area Number |
16K19478
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NOMURA Naohiro 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50735800)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 高血圧 / カリウム / ナトリウム輸送体 / クロライドチャネル / カルシニューリン / ナトリウムチャネル / 生理学 / シグナル伝達 / 電解質輸送 |
|---|
| Outline of Final Research Achievements |
Dietary potassium intake is inversely related to blood pressure and mortality. Moreover, the sodium-chloride cotransporter (NCC) plays an important role in blood pressure regulation and urinary potassium excretion in response to potassium intake. We investigated how potassium regulates NCC activity, and clarified molecular mechanism of NCC regulation by potassium. We found that lower intracellular chloride concentration via ClC-K channel activated NCC, when K intake is low. On the other hand, when K intake is high, calcineurin is activated and suppressed NCC. These molecular mechanism regulates potassium-related hypertension.
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