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Devepolment of renal failure treatment using adipose derived mesenchymal stem cells

Research Project

Project/Area Number 16K19499
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

Yokote Shinya  東京慈恵会医科大学, 医学部, 助教 (30459656)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords慢性腎臓病 / 間葉系幹細胞 / 腎臓再生 / 後腎 / アデニン / 血管石灰化 / 再生医学 / 腎臓病
Outline of Final Research Achievements

In the present study, we explored the potential of ASCs for the treatment of CKD and vascular calcification. CKD was induced in male Sprague-Dawley rats by feeding them a diet containing 0.75% adenine for 4 weeks. ASCs transplantation significantly reduced serum inorganic phosphorus (Pi) as compared to that in the control. The histopathology of the kidneys showed a greater dilation of tubular lumens and interstitial fibrosis in the control group. Calcium and Pi contents of the aorta in the ASCs transplantation group were lower than those in the control group. Von Kossa staining of the thoracic aorta media revealed that ASCs transplantation suppressed vascular calcification. Thus, this study revealed that autogenic ASCs transplantation inhibits kidney damage and suppresses the progression of vascular calcification in the CKD rat model, suggesting that autogenic ASCs transplantation is a novel approach for preventing the progression of CKD and vascular calcification.

Academic Significance and Societal Importance of the Research Achievements

この研究により自己脂肪由来間葉系幹細胞による慢性腎臓病治療の可能性が見いだされた。
慢性腎臓病は日本に1300万人の患者がおり、透析が必要な末期腎不全患者は30万人を超えおり、現在も増加傾向である。日本の透析医療費は1兆5千億円を超えており、この研究が進めば、医療費を圧迫している透析医療の回避に役立つことが予想される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Effect of adipose-derived mesenchymal stem cell transplantation on vascular calcification in rats with adenine-induced kidney disease.2017

    • Author(s)
      Yokote S, Katsuoka Y, Yamada A, Ohkido I, Yokoo T.
    • Journal Title

      scientific reports

      Volume: Oct 25; 7 (1) Issue: 1 Pages: 14036-14036

    • DOI

      10.1038/s41598-017-14492-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Embryonic kidney function in a chronic renal failure model in rodents.2016

    • Author(s)
      Fujimoto E, Yamanaka S, Kurihara S, Tajiri S, Izuhara L, Katsuoka Y, Yokote S, Matsumoto K, Kobayashi E, Okano HJ, Chikaraishi T, Yokoo T.
    • Journal Title

      Clin Exp Nephrol. 2016 Sep 30. [Epub ahead of print]

      Volume: - Issue: 4 Pages: 579-588

    • DOI

      10.1007/s10157-016-1337-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Effect of adipose-derived mesenchymal stem cell transplantation on vascular calcification in rats with adenine-induced kidney disease.2017

    • Author(s)
      Yokote S, Katsuoka Y, Yamada A, Ohkido I, Yokoo T.
    • Organizer
      国際腎臓学会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of autologous adipose-derived mesenchymal stem cell transplantation on vascular calcification in rats with adenine-induced kidney disease.2016

    • Author(s)
      Shinya Yokote
    • Organizer
      日本遺伝子細胞治療学会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 再生腎臓における尿排泄路機構の構築2016

    • Author(s)
      横手伸也、長嶋 比呂志、小林 英司、横尾 隆
    • Organizer
      日本透析医学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2021-02-19  

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