| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We examined renal injury of offspring due to paternal overnutrition. Male Sprague-Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating, and kept each diet during the gestation and lactation period. After 4 weeks postpartum, all the offspring were fed N diet, and followed by 12 weeks. In HFF-offspring, appetite stimulation was recognized, the weight and albuminuria increased from about 8 weeks of age. HFF-offspring developed hyperlipidemia, hyperglycemia, and hypertension. Adiponectin decrease were observed at 16 weeks old in HFF-offspring. Paternal overnutrition may cause impaired glucose tolerance and renal impairment of the offspring in future. To elucidate the mechanism, we focus on adiponectin and investigate. We will evaluate histological glomerular disorders including local adiponectin expression by immunostaining, and add epigenetics analysis.
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