Analysis of inflammasomes in innate immunity of neuromyelitis optica

• Project/Area Number: 16K19505
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Niigata University
• Principal Investigator: SAJI Etsuji 新潟大学, 医歯学総合病院, 助教 (00706418)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 視神経脊髄炎 / 自然免疫 / インフラマソーム / 多発性硬化症 / ミクログリア

Outline of Final Research Achievements

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system (CNS). The detection of NMO IgG autoantibody, which targets the aquaporin-4 water channel, distinguishes NMO from multiple sclerosis. The mRNA levels of inflammasome related genes were increased in active frozen spinal cord tissues of NMOSD. Moreover, sorted lymphocytes from peripheral blood in patients with NMOSD also had the increased mRNA expression of inflammasome related genes and interferon-gamma. These data suggest that innate immunity including inflammasome play an might important role in the pathomechanism of NMOSD.

Research Products

• [Journal Article] Clinicopathological features in anterior visual pathway in neuromyelitis optica (2016)
  • Author(s): Hokari M, Yokoseki A, Arakawa M, Saji E, Yanagawa K, Yanagimura F, Toyoshima Y, Okamoto K, Ueki S, Hatase T, Ohashi R, Fukuchi T, Akazawa K, Yamada M, Kakita A, Takahashi H, Nishizawa M, Kawachi I.
  • Journal Title: Annals of Neurology Volume: 79 Issue: 4 Pages: 605-624
  • DOI: 10.1002/ana.24608
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] A follow-up study of cognitive assessments in a Japanese cohort of multiple sclerosis (2017)
  • Author(s): E. Saji, T. Wakasugi, M. Hokari, F. Yanagimura, K. Yanagawa, M. Nishizawa, O. Onodera, I. Kawachi
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] 診断基準・重症度分類作成に向けた肥厚性硬膜炎の臨床的・免疫学的解析 (2017)
  • Author(s): 佐治越爾, 横関明子, 若杉尚宏, 柳村文寛, 穂苅万李子, 柳川香織, 西澤正豊, 小野寺理, 河内泉
  • Organizer: 第29回日本神経免疫学会学術集会
• [Presentation] Double inversion recovery MRI in the evaluation of the anterior visual pathway in patients with multiple sclerosis and neuromyelitis optica spectrum disorders (2017)
  • Author(s): E. Saji, M. Hokari, A. Yokoseki, T. Wakasugi, F. Yanagimura, K. Yanagawa, M. Nishizawa, O. Onodera, I. Kawachi
  • Organizer: 7th Joint ECTRIMS-ACTRIMS meeting
  • Int'l Joint Research
• [Presentation] 眼窩炎症性偽腫瘍における髄液サイトカイン・ケモカインの検討 (2016)
  • Author(s): 佐治越爾, 西田茉那, 柳村文寛, 穂苅万李子, 若杉尚宏, 柳川香織, 小野寺理, 西澤正豊, 河内泉
  • Organizer: 第28回日本神経免疫学会学術集会
  • Place of Presentation: 長崎ブリックホール（長崎市）
  • Year and Date: 2016-09-29
• [Presentation] Neuromyelitis optica脳病変における神経放射線学的・神経病理学的 特徴 (2016)
  • Author(s): 穂苅万李子, 佐治越爾, 柳村文寛, 柳川香織, 豊島靖子, 柿田明美, 高橋均 , 小野寺理, 西澤正豊, 河内泉
  • Organizer: 第28回日本神経免疫学会学術集会
  • Place of Presentation: 長崎ブリックホール（長崎市）
  • Year and Date: 2016-09-29
• [Presentation] Severe neurodegeneration and unique dynamics of aquaporin-4 on astrocytes in the anterior visual pathway of neuromyelitis optica (2016)
  • Author(s): I Kawachi, M Hokari, A Yokoseki, M Arakawa, E Saji, K Yanagawa, F Yanagimura, Y Toyoshima, A Kakita, H Takahashi, O Onodera, M Nishizawa
  • Organizer: 32nd Congress of the european committee for treatment and research in multiple sclerosisに参加するため
  • Place of Presentation: ExCeL London (London, UK)
  • Year and Date: 2016-09-14
  • Int'l Joint Research