Drug screening for suppression of alpha-synulcein expression
| Project/Area Number |
16K19509
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyoto University |
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Principal Investigator |
Uemura Maiko 京都大学, 医学研究科, 特定研究員 (00767395)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Ryosuke 京都大学, 大学院医学研究科臨床神経学, 教授 (90216771)
UEMURA Norihito 京都大学, 大学院医学研究科臨床神経学, 特定助教 (90749045)
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| Research Collaborator |
OKUDA Shinya 京都大学, 大学院医学研究科臨床神経学, 大学院生
TAGUCHI Tomoyuki 京都大学, 大学院医学研究科臨床神経学, 大学院生
TAMANO Ryotaro 京都大学, 大学院医学研究科臨床神経学, 技術補佐員
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | パーキンソン病 / α-シヌクレイン / 薬剤スクリーニング / シヌクレイン / スクリーニング / 神経科学 / 脳神経疾患 / 薬理学 |
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| Outline of Final Research Achievements |
We performed drug screening using 15 compounds of similar structure and 60 compounds of similar action to compound A and B. We found that the compounds with a certain aromatic ring have potential to suppress alpha-synuclein expression.
At the same time, we developed mouse model which showed alpha-synuclein propagation more rapidly and dramatically. Next, we will infuse the compounds to the brain of alpha-synuclein-propagation mouse model to see the effect of the compounds in vivo.
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Report
(3 results)
Research Products
(9 results)
