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Drug screening for suppression of alpha-synulcein expression

Research Project

Project/Area Number 16K19509
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionKyoto University

Principal Investigator

Uemura Maiko  京都大学, 医学研究科, 特定研究員 (00767395)

Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Ryosuke  京都大学, 大学院医学研究科臨床神経学, 教授 (90216771)
UEMURA Norihito  京都大学, 大学院医学研究科臨床神経学, 特定助教 (90749045)
Research Collaborator OKUDA Shinya  京都大学, 大学院医学研究科臨床神経学, 大学院生
TAGUCHI Tomoyuki  京都大学, 大学院医学研究科臨床神経学, 大学院生
TAMANO Ryotaro  京都大学, 大学院医学研究科臨床神経学, 技術補佐員
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsパーキンソン病 / α-シヌクレイン / 薬剤スクリーニング / シヌクレイン / スクリーニング / 神経科学 / 脳神経疾患 / 薬理学
Outline of Final Research Achievements

We performed drug screening using 15 compounds of similar structure and 60 compounds of similar action to compound A and B. We found that the compounds with a certain aromatic ring have potential to suppress alpha-synuclein expression.
At the same time, we developed mouse model which showed alpha-synuclein propagation more rapidly and dramatically. Next, we will infuse the compounds to the brain of alpha-synuclein-propagation mouse model to see the effect of the compounds in vivo.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion2017

    • Author(s)
      Uemura Maiko T.、Ihara Masafumi、Maki Takakuni、Nakagomi Takayuki、Kaji Seiji、Uemura Kengo、Matsuyama Tomohiro、Kalaria Raj N.、Kinoshita Ayae、Takahashi Ryosuke
    • Journal Title

      Brain Pathology

      Volume: 31 May Issue: 4 Pages: 1-15

    • DOI

      10.1111/bpa.12523

    • NAID

      120006305874

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity2017

    • Author(s)
      Uemura Maiko T.、Asano Takeshi、Hikawa Rie、Yamakado Hodaka、Takahashi Ryosuke
    • Journal Title

      Neuroscience Research

      Volume: 124 Pages: 25-32

    • DOI

      10.1016/j.neures.2017.05.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Inoculation of alpha-synuclein fibrils into the mouse gastrointestinal tract induces Lewy-like pathology in the brain via the vagal nerve2017

    • Author(s)
      上村紀仁、上村麻衣子、八木寿梓、高橋良輔
    • Organizer
      World congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel mice model for Parkinson's disease: fibril-inoculated mutant α-synuclein BAC transgenic mice2017

    • Author(s)
      奥田真也、上村紀仁、上村麻衣子、山門穂高、高橋良輔
    • Organizer
      World congress of Neurology
    • Related Report
      2017 Annual Research Report
  • [Presentation] αシヌクレイントランスジェニックマウスへのフィブリル脳内接種によるパーキンソン病モデル作製2017

    • Author(s)
      奥田真也、上村紀仁、上村麻衣子、山門穂高、高橋良輔
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2017 Annual Research Report
  • [Presentation] Does inoculation of α-synuclein fibrils promote Lewy-pathology of α-synuclein BAC transgenic mice?2016

    • Author(s)
      奥田真也、上村紀仁、生野真嗣、山門穂高、高橋良輔
    • Organizer
      第10回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Inoculation of α-synuclein fibrils to α-synuclein BAC transgenic mice did not accelerate Lewy-like pathology2016

    • Author(s)
      奥田真也、上村紀仁、高橋良輔
    • Organizer
      第39回神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Glucocerebrosidase deficiency accelerates the propagation of alpha-Synuclein pathology2016

    • Author(s)
      上村紀仁、長谷川成人、髙橋良輔
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Book] 神経疾患治療ストラテジー2017

    • Author(s)
      祖父江元
    • Total Pages
      451
    • Publisher
      中山書店
    • ISBN
      9784521745435
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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