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• Project/Area Number: 16K19510
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: Shimotake Akihiro 京都大学, 医学研究科, 特定助教 (80726000)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 漢字 / かな / 日本語 / 言語 / 皮質電気刺激 / 事象関連電位 / 機能代償 / 仮名 / 電気刺激 / 皮質皮質間誘発電位 / 神経心理 / 読字書字 / 読字 / 書字

Outline of Final Research Achievements

Japanese words are unique language, consisting of syllabogram, kana word, and morphogram, kanji word. Anatomo-functional connectivity and plasticity for kana and kanji reading and writing processing have not been well clarified. We aimed to reveal their details by means of a multidisciplinary approach, applying the invasive neurophysiology, neuropsychology and neuroimaging methods to patients who underwent presurgical evaluation of epilepsy surgery.
In this study, we revealed that the ventral part of the anterior temporal lobe plays a crucial role in kanji and kana word reading. We could obtain the evidence for the dynamic reorganization of kanji/kana reading and writing from the longitudinal neuropsychological assessment in epilepsy surgery patients.

Academic Significance and Societal Importance of the Research Achievements

読字・書字脳内機能野の漢字・仮名での共通性・差異から、日本語特有の文字を扱う脳内処理機構の解明を行った。また、日本語特有の症候をヒト一般に発展させて、ヒトの文字を扱う脳内神経基盤の解明に貢献した。臨床的には、脳損傷患者の漢字・仮名の脳内処理機能の回復機構の予測、機能予後予測が可能となり、リハビリテーション方法の選択において重要な知見になると考えられた。

Research Products

• [Int'l Joint Research] University of Manchester/University of Cambridge(英国)
• [Journal Article] A rational, multispectral mapping algorithm for primary motor cortex: A primary step before cortical stimulation (2019)
  • Author(s): Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Takefumi Hitomi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto, Susumu Miyamoto, Ryosuke Takahashi, Hirofumi Maruyama, Akio Ikeda
  • Journal Title: Epilepsia Volume: 60 Issue: 3 Pages: 547-559
  • DOI: 10.1111/epi.14669
  • Peer Reviewed / Open Access
• [Journal Article] 症例 アンカーボルトを用いた定位的深部電極挿入術(stereotactic EEG insertion)の初期経験-課題の抽出と挿入精度向上の検討 (2018)
  • Author(s): 稲田 拓、下竹 昭寛、山尾 幸広、吉田 和道、國枝 武治、松本 理器、池田 昭夫、宮本 享、菊池 隆幸、小林 勝哉、中江 卓郎、西田 誠、高橋 由紀、小林 環、永井 靖識、松本 直樹
  • Journal Title: Neurological Surgery 脳神経外科 Volume: 46 Issue: 10 Pages: 917-924
  • DOI: 10.11477/mf.1436203839
  • ISSN: 0301-2603, 1882-1251
  • Year and Date: 2018-10-10
  • Peer Reviewed
• [Journal Article] Strategy for epilepsy surgery: mapping the dual language pathways for preservation of language function (2018)
  • Author(s): 松本 理器、下竹 昭寛、山尾 幸広、菊池 隆幸、國枝 武治
  • Journal Title: Japanese Journal of Neuropsychology Volume: 34 Issue: 2 Pages: 124-134
  • DOI: 10.20584/neuropsychology.17027
  • NAID: 130007466712
  • ISSN: 0911-1085, 2189-9401
  • Year and Date: 2018-06-25
  • Peer Reviewed
• [Journal Article] Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery. (2018)
  • Author(s): Neshige S, Matsuhashi M, Kobayashi K, Sakurai T, Shimotake A, Hitomi T, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Miyamoto S, Maruyama H, Matsumoto M, Ikeda A.
  • Journal Title: Clin Neurophysiol. Volume: 129 Issue: 9 Pages: 2038-2048
  • DOI: 10.1016/j.clinph.2018.06.007
  • Peer Reviewed
• [Journal Article] Do scalp-recorded slow potentials during neuro-feedback training reflect the cortical activity? (2018)
  • Author(s): Tomoyuki Fumuro, Masao Matsuhashi, Riki Matsumoto, Kiyohide Usami, Akihiro Shimotake, Takeharu Kunieda, Takayuki Kikuchi, Kazumichi Yoshida, Ryosuke Takahashi, Susumu Miyamoto, Akio Ikeda
  • Journal Title: Clinical Neurophysiology Volume: 129 Pages: 1884-1890
  • Peer Reviewed
• [Journal Article] てんかんの治療戦略：てんかん外科における言語機能温存へ向けた試み． (2018)
  • Author(s): 松本理器,下竹昭寛,山尾幸広,菊池隆幸,國枝武治．
  • Journal Title: 神経心理学 Volume: in press
  • NAID: 130007466712
• [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study. (2017)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
  • Journal Title: Sleep Volume: 40 Issue: 8 Pages: 1-7
  • DOI: 10.1093/sleep/zsx077
  • Peer Reviewed
• [Journal Article] A case of epilepsy induced by eating or by visual stimuli of food made of minced meat (2017)
  • Author(s): 三村 直哉、井上 岳司、下竹 昭寛、松本 理器、池田 昭夫、高橋 良輔
  • Journal Title: Rinsho Shinkeigaku Volume: 57 Issue: 8 Pages: 430-435
  • DOI: 10.5692/clinicalneurol.cn-001001
  • NAID: 130006034996
  • ISSN: 0009-918X, 1882-0654
  • Peer Reviewed
• [Journal Article] A case of neurosyphilis presenting with limbic encephalitis (2017)
  • Author(s): 月田和人, 下竹昭寛, 中谷光良, 高橋幸利, 池田昭夫, 高橋良輔
  • Journal Title: Rinsho Shinkeigaku Volume: 57 Issue: 1 Pages: 37-40
  • DOI: 10.5692/clinicalneurol.cn-000936
  • NAID: 130005310355
  • ISSN: 0009-918X, 1882-0654
  • Peer Reviewed / Open Access
• [Journal Article] Elderly woman with exaggerated startle reflex and unconscious drop attack (in press) (2016)
  • Author(s): Neshige S, Kobayashi K, Shimotake A, Iemura T, Matsumoto R, Nishinaka K, Matsumoto M, Takahashi R, Ikeda A.
  • Journal Title: Neurology and Clinical Neuroscience Volume: in press Issue: 4 Pages: 156-158
  • DOI: 10.1111/ncn3.12055
  • Peer Reviewed / Open Access
• [Presentation] The role of the insula in Sense of Agency: supportive data from neurosurgical cases (2018)
  • Author(s): Tamaki Kobayashi, Riki Matsumoto, Akihiro Shimotake, Masaya Togo, Yoshiki Arakawa, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Akio Ikeda, Shiro Yano, Takaki Maeda, Hiroshi Imamizu, Susumu Miyamoto
  • Organizer: 16th Asian Oceanian Congress Of Neurology
  • Int'l Joint Research
• [Presentation] Role of the premotor and precentral negative motor area in praxis: a direct electrical stimulation study with behavioral analysis (2018)
  • Author(s): Masaya Togo, Riki Matsumoto, Akihiro Shimotake, Tamaki Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 31st International Congress of Clinical Neurophysiology
  • Int'l Joint Research
• [Presentation] Rational cortical mapping algorithm for epilepsy surgery: non-stimuli, multi-intrinsic brain activities without cortical stimulation (2018)
  • Author(s): Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Akihiro Shimotake, Takehumi Hitomi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto*, Ryosuke Takahashi, Susumu Miyamoto, Hirofumi Maruyama, Akio Ikeda.
  • Organizer: the 12th Asian&Oseanian Epilepsy Congress
  • Int'l Joint Research
• [Presentation] Human medial parietal cortices have distinct connectivity patterns: Evidence from standardized connectivity map using cortico-cortical evoked potential (2018)
  • Author(s): Masaya Togo, Riki Matsumoto, Takuro Nakae, Hirohumi Takeyama, Katsuya Kobayashi, Kiyohide Usami, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 第41回神経科学大会
• [Presentation] Electrocorticography-based non-primary motor area mapping comparable with cortical stimulation (2018)
  • Author(s): Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Akihiro Shimotake, Takehumi Hitomi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto*, Ryosuke Takahashi, Susumu Miyamoto, Hirofumi Maruyama, Akio Ikeda
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] Role of premotor and precentral negative motor area in praxis: a direct electrical stimulation study (2018)
  • Author(s): Masaya Togo, Riki Matsumoto, Akihiro Shimotake, Tamaki Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] Compensation of semantic memory after dominant anterior temporal lobe resection in epilepsy surgery (2018)
  • Author(s): Makiko Ota, Akihiro Shimotake, Riki Matsumoto, Mitsuhiro Sakamoto, Masako Daifu, Takuro Nakae, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Matthew Lambon Ralph, Akio Ikeda
  • Organizer: 第41回日本神経科学大会?
• [Presentation] Chronological Volumetry of Amygdala, Hippocampus and Whole Brain and Association with Clinical Course in Patients with Anti Voltage-gated Potassium Channel-complex Antibodies Associated Limbic Encephalitis(VGKC-LE) (2018)
  • Author(s): Masayuki Honda, Riki Matsumoto、Akihiro Shimotake、Yuichiro Hashi、 Mitsuhiro Sakamoto、Daiki Fujii、Katsuya Kobayashi、Takahiro Mitsueda、 Akira Kuzuya、Ryosuke Takahashi、Akio Ikeda
  • Organizer: 第52回日本てんかん学会学術集会
• [Presentation] Role of premotor and precentral negative motor area in praxis: a direct electrical stimulation study (2018)
  • Author(s): M. Togo, R. Matsumoto, A. Shimotake, T. Kobayashi, T. Kikuchi, K. Yoshida, T. Kunieda, S. Miyamoto, R. Yakahashi and A. Ikeda
  • Organizer: May 23-26 59th annual meeting of the Japanese society of neurology
• [Presentation] Visual and auditory semantic processing converges in the anterior temporal lobe (2018)
  • Author(s): Akihiro Shimotake, Riki Matsumoto, Katsuya Kobayashi, Takayuki Kikuchi, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Matthew Lambon-Ralph, Akio Ikeda
  • Organizer: The 41th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Double dissociation of the semantic and phonological processing in reading Kanji and Kana words - A quantitative low-intensity cortical stimulation study (2018)
  • Author(s): Masako Daifu, Riki Matsumoto, Akihiro Shimotake1), Makiko Ota, Mitsuhiro Sakamoto, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Matthew A. Lambon Ralph, Akio Ikeda
  • Organizer: The 41th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Compensation of semantic memory after dominant anterior temporal lobe resection in epilepsy surgery (2018)
  • Author(s): Makiko Ota, Akihiro Shimotake, Riki Matsumoto, Mitsuhiro Sakamoto, Masako Daifu, Takuro Nakae, Takayuki. Kikuchi Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Matthew A. Lambon Ralph, Akio Ikeda
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] Functional mapping of visual and auditory semantic processing in the anterior temporal lobe (2018)
  • Author(s): SHIMOTAKE Akihiro, MATSUMOTO Riki, KOBAYASHI Katsuya, KIKUCHI Takayuki , MASAO Matsuhashi, KAZUMICHI Yoshida, KUNIEDA Takeharu, MIYAMOTO Susumu, TAKAHASHI Ryosuke, IKEDA Akio
  • Organizer: 第52回日本てんかん学会学術集会
• [Presentation] Underlying excitability at the focus modulates network dynamics of seizure propagation: a single-pulse electrical stimulation study time-locked to spike and post-spike slow. (2018)
  • Author(s): Katsuya Kobayashi, Riki Matsumoto, Kiyohide Usami, Akihiro Shimotake, Masao Matsuhashi, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Akio Ikeda.
  • Organizer: American Epilepsy Society (AES) 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] 高頻度皮質電気刺激による高次運動障害の発現機構の検討：皮質刺激誘発反応と行動解析の包括的検討 (2018)
  • Author(s): 十河正弥、松本理器、下竹昭寛、 松橋眞生、小林環、菊池隆幸、吉田和道、國枝武治、宮本享、髙橋良輔、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 発語失行の病態：機能マッピング，電気的線維追跡からの症例の考察 (2018)
  • Author(s): 坂本光弘、松本理器、下竹昭寛、太田真紀子、中谷光良、中江卓郎、菊池隆幸、吉田和道、國枝武治、髙橋良輔、池田昭夫
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] 言語ネットワーク内における中核言語野の結合様式の検討 (2018)
  • Author(s): 尾谷-山田真弓、松本理器、下竹昭寛、坂本光弘、十河正弥、中江卓郎、武山博文、小林勝哉、宇佐美清英、松橋眞生、山尾幸弘、菊池隆幸
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 側頭葉腫瘍切除症例における意味認知機能の検討 (2018)
  • Author(s): 下竹昭寛、松本理器、太田真紀子、坂本光弘、中江卓郎、菊池隆幸、荒川芳輝、國枝武治、宮本享、高橋良輔、池田昭夫
  • Organizer: 第42回 日本神経心理学会学術集会
• [Presentation] 低い刺激強度の皮質電気刺激と呼称課題の組み合わせによる言語機能マッピングの有用性 (2018)
  • Author(s): 下竹 昭寛、松本 理器、坂本 光弘、中谷 光良、太田 真紀子、小林 勝哉、菊池 隆幸、吉田 和道、國枝 武治、宮本 享、髙橋 良輔、池田 昭夫
  • Organizer: 第59回日本神経学会学術大会;
• [Presentation] 皮質電気刺激による脳機能マッピング (2018)
  • Author(s): 松本理器、下竹昭寛、十河正弥、菊池隆幸、國枝武治、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
  • Invited
• [Presentation] てんかんにおける覚醒下手術の役割 (2018)
  • Author(s): 菊池隆幸、小林環、永井靖識、山尾幸広、吉田和道、小林勝哉、下竹昭寛、松本理器、池田昭夫、國枝武治、宮本享
  • Organizer: 第52回日本てんかん学会学術集会
• [Presentation] 島皮質障害による運動主体感の動的変容：脳外科手術症例からの知見．OS21：身体性システム．脳内身体表現のモデル化からリハビリテーション (2018)
  • Author(s): 松本理器、小林環、下竹昭寛、吉田和道、矢野史朗、前田貴記、今水寛，池田昭夫
  • Organizer: 第36回日本ロボット学会
  • Invited
• [Presentation] てんかんネットワークの結合性はてんかん焦点での興奮・抑制により動的に変動する：皮質皮質間誘発電位を用いた検討 (2018)
  • Author(s): 小林勝哉、松本理器、宇佐美清英、下竹昭寛、山尾幸宏、菊池隆幸、吉田和道、國枝武治、高橋良輔、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 皮質刺激皮質誘発電位（CCEP）における律動反応 機能ネットワークから見た反応特性の多様性 (2018)
  • Author(s): 中江卓郎、松本理器、十河正弥、武山博文、小林勝哉、下竹昭寛、松橋眞生、山尾幸広、菊池隆幸、吉田和道、國枝武治、池田昭夫、宮本享
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 「行為」における陰性運動野の役割：高頻度皮質電気刺激を用いた検討 (2018)
  • Author(s): 十河正弥、松本理器、下竹昭寛、小林環、菊池隆幸、吉田和道、國枝武治、宮本享、髙橋良輔、池田昭夫．
  • Organizer: 脳機能セミナー
• [Presentation] Role of the anterior temporal lobe in the ventral pathway: evidence from presurgical evaluations in epilepsy patient (2017)
  • Author(s): Shimotake A, Matsumoto R, Kikuchi R, Yoshida K, Kunieda R, Ikeda A.
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
  • Invited
• [Presentation] Functional mapping of praxis : Electrical cortical stimulation study (2017)
  • Author(s): Shimotake A, Matsumoto R, Kobayashi K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A,
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] 皮質電気刺激による行為関連ネットワークマッピング (2017)
  • Author(s): 下竹昭寛,松本理器,小林勝哉,國枝武治,三國信啓,宮本亨,高橋良輔,池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
• [Presentation] マラソンレクチャー：vEEG 成人ケーススタディ(Long-term video EEG monitoring in adults) (2017)
  • Author(s): 下竹昭寛
  • Organizer: 第51回日本てんかん学会学術集会
  • Invited
• [Presentation] てんかんの治療戦略：てんかん外科における言語機能温存へ向けた試み. シンポジウムII．高次脳機能障害の治療戦略． (2017)
  • Author(s): 松本理器，下竹昭寛，山尾幸広，菊池隆幸，國枝武治
  • Organizer: 第41回日本神経心理学会
  • Invited
• [Presentation] Safety of single-pulse electrical stimulation for cortico-cortical evoked potentials in epileptic human cerebral cortex (2017)
  • Author(s): Kobayashi K, Matsumoto R, Usami K, Matsuhashi M, Shimotake A, Nakae T, Takeyama H, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Functional gradient of the ventral temporal area in reading Kanji and Kana words -A quantitative low-intensity cortical stimulation study (2017)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Ota M, Sakamoto M, Nakae T, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Lambon Ralph M, Ikeda A
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Compensatory semantic processing after resection of the anterior temporal lobe in epilepsy surgery (2017)
  • Author(s): Ota M, Shimotake A, Matsumoto R, Sakamoto M, Daifu M, Nakae T, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Matthew L.R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Role of the negative motor area in praxis: A high frequency electrical cortical stimulation study (2017)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Jeavonssyndrome can manifest paroxysmal alexia:acase report (2017)
  • Author(s): Yamada-Otani M, Matsumoto R, Shimotake A, Uehara N, Demura A, Kinoshita M, Takahashi R, Ikeda A.
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Invasive 3D source localization by wide-band electroencephalography findings (2017)
  • Author(s): Murai T, Matsuhashi M, Hitomi T, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] The human entorhinal cortex is connected with the broad neocortical regions through the hippocampalthalamo-cortical pathway possible as the memory network: Results from electrical tract tracing and neuropsychologicalassessment (2017)
  • Author(s): Takeyama H, Matsumoto R, Nakae T, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R Ikeda A
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Fronto-parietal network in language-dominant hemisphere: an intraoperative CCEP (cortico-cortical evoked potential) study (2017)
  • Author(s): Nakae T, Matsumoto R, Arakawa Y, Inada R, Nishida S, Inada T, Takahashi Y, Kobayashi T, Kobayashi K, Yamao Y, Shimotake A, Kikuchi T, Aso T, Yoshida K, Kunieda T, Takahashi R, Ikeda A, Miyamoto S
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Higher-order motor cortices actively engage in motor inhibition: cortical stimulation and event-related potentials as an evidence from subdural electrodes (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: The XXXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Efficacy of Wide-Band Electrocorticography(ECoG) on Mapping of the Primary Sensori-Motor Area Compared with Electrical Cortical Stimulation (ECS) (2017)
  • Author(s): Neshige S, Matsuhashi M, Sakurai T, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R and Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] 皮質脳波と高次脳機能ネットワーク (2017)
  • Author(s): 松本理器、下竹昭寛，菊池隆幸，國枝武治、池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
  • Invited
• [Presentation] Active engagement of higher-order motor cortices in motor inhibition: Evidence fromdirect neural recording and stimulation during Go/No-Go paradigm (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Functional connectivity from human superior parietal lobule and medial parietal lobe: A cortico-coritcal evoked potential (CCEP) study (2017)
  • Author(s): Togo M, Matsumoto R, Nakae T, Takeyama H, Kobayashi K, Shimotake A, Usami K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Scoring System of Combination of Movement-related Cortical Potential and Event-related Synchronization/De-synchronization for Functional Mapping of Primary Motor Areas Concordant with Electrical Cortical Stimulation (2017)
  • Author(s): Neshige S, Matsuhashi M, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] Role of the Negative Motor Area in Praxis: A High Frequency Electrical Cortical Stimulation Study (2017)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] Source localization of seizure focus by wide-band stereoelectroencephalography (2017)
  • Author(s): Murai T, Matsuhashi M,Hitomi T, Toho M, Kobayashi K, Shimotake A, Inouchi M, Kikuchi K, Yoshida K, Kunieda R, Matsumoto R, Kanda R, Takahashi R, Ikeda A
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] 皮質皮質間誘発電位における非典型波形の検討 (2017)
  • Author(s): 迎伸孝, 松本理器, 小林勝哉, 十河正弥, 松橋眞生, 中江卓郎, 武山博文, 下竹昭寛, 山尾幸広, 菊池隆幸, 吉田和道, 飯原弘二, 髙橋良輔 and 池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
• [Presentation] The ventral part of the anterior temporal lobe actively engages in Kanji word processing: a direct cortical stimulation study (2016)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Kobayashi K, Ota M, Sakamoto M, Nakae T, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Lambon Ralph MA, Ikeda A:
  • Organizer: 70th American Epilepsy Society Annual Meeting
  • Place of Presentation: Houston, USA
  • Year and Date: 2016-12-02
  • Int'l Joint Research
• [Presentation] Kanji word processing in the ventral anterior temporal lobe: a postoperative neuropsychological study in patients with temporal lobe epilepsy (2016)
  • Author(s): Ota M, Shimotake A, Matsumoto R, Sakamoto M, Daifu M, Nakae T, Kunieda T, Miyamoto S, Takahashi R, Lambon-Ralph MA, Ikeda A
  • Organizer: Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Probing the ventral fronto-temporal pathway in the language dominant hemisphere; an intraoperative cortico-cortical evoked potential study (2016)
  • Author(s): Nakae T, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi T, Inada T, Takahashi Y, Nishida S, Kobayashi K, Shimotake A, Matsuhashi M, Inano Y, Yamao Y,Kikuchi T, K Yoshida, Ikeda A, Miyamoto S
  • Organizer: Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 日本語読みにおける側頭葉底面の前後方向の機能の相違：高頻度皮質刺激による研究 (2016)
  • Author(s): 大封昌子，松本理器，下竹昭寛，太田真紀子，坂本光弘，中江卓郎，小林勝哉，菊池隆幸，吉田和道，國枝武治，髙橋良輔，Lambon Ralph MA，池田昭夫
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島
  • Year and Date: 2016-10-27
• [Presentation] Functional brain mapping of primary sensorimotor cortex by means of MRCP and ERS/ERD comparing with CSM (2016)
  • Author(s): Neshige S, Sakurai T, Kobayashi K, Shimotake A, Matsuhashi M, Matsumoto R, Hitomi T, Matsumoto M, Takahashi R, Ikeda A
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島
  • Year and Date: 2016-10-27
• [Presentation] 呼称課題を用いた低刺激強度皮質電気刺激の言語機能マッピングの有用性 (2016)
  • Author(s): 下竹昭寛，松本理器，坂本光弘，中谷光良，太田真紀子，小林勝哉，菊池隆幸，吉田和道，國枝武治，宮本享，髙橋良輔，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-02
• [Presentation] 側頭葉底面前方領域切除による意味記憶の変容と機能可塑性の解明 (2016)
  • Author(s): 太田真紀子，松本理器，下竹昭寛，坂本光弘，大封昌子，中江卓郎，菊池隆幸，吉田和道，國枝武治，宮本享，髙橋良輔，Lambon Ralph MA，池田昭夫
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-10-02
• [Presentation] 左中心前回中・下部に限局した腫瘍切除後にanarthriaを呈した1例 (2016)
  • Author(s): 坂本光弘，松本理器，下竹昭寛，太田真紀子，中谷光良，菊池隆幸，吉田和道，國枝武治，池田昭夫
  • Organizer: 第40回日本神経心理学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2016-09-15
• [Presentation] Functional mapping of praxis: Electrical cortical stimulation study (2016)
  • Author(s): Shimotake A, Matsumoto R, Kobayashi K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Ventral part of the anterior temporal lobe actively engages in Kanji reading: Evidence from direct cortical stimulation of the basal temporal language area. (2016)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Sakamoto M, Ota M, Kunieda T, Miyamoto S, Takahashi R, Lambon Ralph MA, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Antero-posterior gradients exist in functional connections between human inferior frontal gyrus and middle and posterior temporal gyri: An intraoperative cortico-cortical evoked potential study. (2016)
  • Author(s): Nakae T, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi T, Inada T, Takahashi Y, Nishida S, Inano R, Kobayashi K, Shimotake A, Matsuhashi M, Kikuchi T, Takahashi R, Ikeda A, Miyamoto S
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Compensatory mechanisms of semantic- and kanji / kana word processing after resection of the anterior temporal lobe (in epilepsy surgery). (2016)
  • Author(s): Ota M, Shimotake A, Matsumoto R, Sakamoto M, Daifu M, Nakae T, Kunieda T, Miyamoto S, Takahashi R, Lambon-Ralph MA, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Human motor inhibition network as revealed by epicortical ERP, CCEP and high frequency cortical stimulation (2016)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Functional connectivity from medial parietal cortex and superior parietal lobule: a cortico-cortical evoked potential study (2016)
  • Author(s): Togo M, Matsumoto R, Takeyama H, Kobayashi K, Shimotake A, Usami K, Inouchi M, Nakae T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] Functional mapping of praxis network: Electrical cortical stimulation study. (2016)
  • Author(s): Shimotake A, Matsumoto R, Togo M, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08
• [Presentation] Role of left ventral precentral gyrus in apraxia of speech: documents with electrical cortical stimulation and focal resection. (2016)
  • Author(s): Sakamoto M, Matsumoto R, Shimotake A, Nakae T, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08
• [Presentation] Functional connectivity from human superior pariental lobule and medial pariental lobe: a cortico-cortical evoked potential (CCEP) study (2016)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Inouchi M, Kunieda T, Ikeda A
  • Organizer: The 1st International Symposium on Embodied-Brain Systems Science (EMBOSS2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-05-08
• [Book] 代謝性・中毒性脳症の脳波、特集テーマ：脳波が主役：意識障害・神経救急の診断学/臨床神経生理学 (2019)
  • Author(s): 下竹昭寛,松本理器,人見健文,池田昭夫
  • Publisher: 一般社団法人 日本神経生理学会
• [Book] 臨床神経生理検査入門 皮質脳波記録 (2017)
  • Author(s): 下竹昭寛、松本理器
  • Total Pages: 288
  • Publisher: 中山書店
• [Book] 6てんかん総論，ここが知りたい！臨床神経生理 (2016)
  • Author(s): 下竹昭寛，池田昭夫
  • Publisher: 中外医学社
• [Book] 皮質脳波記録，Clinical Neuroscience (2016)
  • Author(s): 下竹昭寛，國枝武治，松本理器
  • Publisher: 中外医学社
• [Book] 特集：神経生理最前線，てんかん外科における術前皮質・白質機能マッピング，最新精神医学 (2016)
  • Author(s): 松本理器，下竹昭寛，山尾幸広，國枝武治
  • Publisher: 世論時報社
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学講座
  • URL: http://epilepsy.med.kyoto-u.ac.jp/research
• [Remarks] 京都大学大学院医学研究科臨床神経学
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/laboratory/lab_3_5.htm
• [Remarks] 京都大学大学院てんかん・運動異常生理学講座
  • URL: http://epilepsy.med.kyoto-u.ac.jp/results