Study of the pathogenicity of the ganglionic acetylcholine receptor antibodies in autoimmune autonomic ganglionopathy
Project/Area Number |
16K19515
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Kumamoto University |
Principal Investigator |
Mukaino Akihiro 熊本大学, 医学部附属病院, 特任助教 (50754173)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 自己免疫性自律神経節障害 / 抗自律神経節アセチルコリン受容体抗体 / 自己免疫性消化管運動障害 / ルシフェラーゼ免疫沈降法 / 脳神経疾患 / 内科 |
Outline of Final Research Achievements |
During analysis of clinical features of seropositive autoimmune autonomic ganglionopathy, we detected severe gastrointestinal dysmotility cases including achalasia, paralytic ileus, and chronic intestinal pseudo-obstruction (CIPO). Autoimmune gastrointestinal dysmotility (AGID) is the entity proposed in 2008 in United States and it is the antibody-mediated disorder including anti-ganglionic acetylcholine receptor (gAChR) antibody. We performed clinical analysis of esophageal achalasia and CIPO, obtained these serums, measured anti-gAChR antibody, and found that 21.4% of achalasia and 50% of CIPO were seropositive.
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Academic Significance and Societal Importance of the Research Achievements |
食道アカラシアと慢性偽性腸閉塞症の症例も多くは自律神経障害を有することが判明した。これは自己免疫性消化管運動障害と抗自律神経節アセチルコリン受容体抗体に関する本邦における初めての研究で、これをJournal of Gastroenterology誌に論文として報告し、国内複数の学会で発表した。第28回日本神経免疫学会学術集会ではYoung neuroimmunologist Awardを受賞した。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Autoimmune postural orthostatic tachycardia syndrome2018
Author(s)
Mari Watari, Shunya Nakane, Akihiro Mukaino, Makoto Nakajima, Yukiko Mori, Yasuhiro Maeda, Teruaki Masuda, Koutaro Takamatsu, Yanosuke Kouzaki, Osamu Higuchi, Hidenori Matsuo, Yukio Ando
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Journal Title
Ann Clin Transl Neurol.
Volume: 5
Pages: 486-492
Related Report
Peer Reviewed / Open Access
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[Journal Article] Anti-ganglionic AChR antibodies in Japanese patients with motility disorders2018
Author(s)
Mukaino A, Minami H, Isomoto H, Hamamoto H, Ihara E, Maeda Y, Higuchi O, Okanishi T, Kokudo Y, Deguchi K, Sasaki F, Ueki T, Murata KY, Yoshida T, Kinjo M, Ogawa Y, Ido A, Matsuo H, Nakao K, Nakane S
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Journal Title
J Gastroenterol
Volume: 53
Issue: 12
Pages: 1227-1240
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia.2018
Author(s)
Koutaro Takamatsu, Shunya Nakane, Shigeaki Suzuki, Takayuki Kosaka, Satoshi Fukushima, Toshihiro Kimura, Azusa Miyashita, Akihiro Mukaino, Shiori Yamakawa, Keisuke Watanabe, Masatoshi Jinnin, Yoshihiro Komohara, Hironobu Ihn, and Yukio Ando
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Journal Title
Ann Clin Transl Neurol.
Volume: 5
Issue: 11
Pages: 1421-1427
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CSF TACI and BAFF levels in patients with primary CNS lymphoma as novel diagnostic biomarkers.2018
Author(s)
Mizutani H, Nakane S, Ikeda T, Nakamura H, Takamatsu K, Makino K, Tawara N, Mukaino A, Watari M, Matsui H, Mukasa A, Ando Y
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Journal Title
Annals of clinical and translational neurology
Volume: 5
Issue: 12
Pages: 1611-1616
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Autoimmune postural orthostatic tachycardia syndrome.2018
Author(s)
Watari M, Nakane S, Mukaino A, Nakajima M, Mori Y, Maeda Y, Masuda T, Takamatsu K, Kouzaki Y, Higuchi O, Matsuo H, Ando Y.
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Journal Title
Ann Clin Transl Neurol.
Volume: 5
Pages: 486-492
Related Report
Peer Reviewed
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[Presentation] Clinical features of ganglionic acetylcholine receptor β4 seropositive autoimmune autonomic ganglionopathy and utility of 123I-MIBG myocardial scintigraphy.2017
Author(s)
Akihiro Mukaino, Shunya Nakane, Osamu Higuchi, Yasuhiro Maeda, Makoto Yamakawa, Koutaro Takamatsu, Mari Watari, Takayuki Kosaka, Teruaki Masuda, Hidenori Matsuo, Yukio Ando.
Organizer
World congress of neurology 2017
Related Report
Int'l Joint Research
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[Presentation] 消化管運動障害における抗自律神経節アセチルコリン受容体抗体の検出: 本邦におけるautoimmune gastrointestinal dysmotilityの検討,2017
Author(s)
向野晃弘, 中根俊成, 南ひとみ, 磯本 一, 樋口 理, 岡西 徹,村田顕也, 井戸章雄, 松尾秀徳, 中尾一彦, 安東由喜雄
Organizer
第45回日本臨床免疫学会総会
Related Report
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