Neural substrates of masked-face in Parkinson disease: A quantitative analysis of facial expression.
| Project/Area Number |
16K19517
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
KOYANO Shigeru 横浜市立大学, 医学研究科, 客員教授 (50315818)
DOI Hiroshi 横浜市立大学, 医学部, 准教授 (10326035)
TANAKA Fumiaki 横浜市立大学, 医学研究科, 教授 (30378012)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | パーキンソン病 / 仮面様顔貌 / Parkinson / amimia / 記憶 / 情動 / 表情 / 認知機能 / MRI / 脳神経疾患 / 脳・神経 / 臨床 / 神経科学 |
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| Outline of Final Research Achievements |
To clarify pathophysiology of the masked face in Parkinson disease (PD), we analyzed temporal changes of facial expression using motion capture technique. We also investigated the relationships between masked-face and cognitive / affective symptoms and investigated neural substrate for masked-face using neuroimaging analyses. As a result, we studied 38 PD patients and 24 healthy controls, and we found a significant decrease of facial expression in the PD group. In addition, facial expression score was associated with psychological score such as attention / executive function, and depression scores. Furthermore, the resting state fMRI analysis showed significant differences in functional connectivity mainly in the frontal lobe in the PD with sever masked-face group. We concluded that the masked face of PD might be related to not only motor symptoms but also cognitive affective disorders.
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Report
(3 results)
Research Products
(1 results)
