| Project/Area Number |
16K19524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | パーキンソン病 / iPS細胞 / ドーパミン神経 / オートファジー / マイトファジー / ドパミン神経 |
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| Outline of Final Research Achievements |
We conducted this research aimed at establishing dopamine neuron specific disease models by discovering dysfunctions of dopaminergic neurons using iPS cells derived from hereditary Parkinson's disease patients, leading to clarification of the pathology and development of therapeutic methods It was. As main results, (1) established a highly pure iPS cell-derived dopamine nerve induction method. (2) Autophagic abnormality, alpha synuclein accumulation, and cell vulnerability were detected in PARK2/4/6/8/9-neurons. (3) We established a more sensitive mitochondrial anomaly detection method in dopaminergic neurons derived from PARK2 cells. (4) PARK2/6-dopamine neuron-specific phosphorylated ubiquitination signal abnormality was detected. These results were announced at conferences as appropriate, and some were reported to international journals.
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