| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Resistin is a cytokine associated with insulin resistance, inflammation, and cardiovascular diseases. In the Japanese cohort, serum resistin is tightly associated with a single nucleotide polymorphism (SNP) at -420 in the human resistin gene. The aim of this study is to investigate the association between serum resistin levels and environmental factors, and the effect of SNP-420 on this association. White blood cell count and SNP-420 genotype interactively increased serum resistin. The inverse association between serum resistin and n-3 polyunsaturated fatty acids intake was strongest in the SNP-420 G/G genotype. The inverse association between serum resistin and physical activity was strongest in the G/G genotype. In conclusion, serum resistin was associated with SNP-environmental interactions.
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