Clinical significance of molecular dynamics of diabetic angiopathy related to Innate Lymphoid cell (ILC).

Research Project

Project/Area Number	16K19543
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Metabolomics
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	Ushigome Emi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80440890)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	自然免疫リンパ球 / 糖尿病 / 動脈硬化 / 自然免疫リンパ系細胞（ILC） / 糖尿病コホート / 自然免疫 / 糖尿病コホート研究
Outline of Final Research Achievements	In Apolipoprotein E knockout (ApoE KO) mice fed with an atherogenic diet (F2HFD1), the percentage of various ILC subsets from ILCs was varied. ILC1 frequencies were increased in thoracic aorta and blood, and ILC2 frequencies were increased in epididymal fat. We performed a case-control study to examine the frequency of peripheral blood ILC subset in patients with type 2 diabetes compared with those in healthy individuals using KAMOGAWA-DM cohort. ILC2 frequencies were increased in T2DM relative to the total peripheral blood ILC (Lin- CD127+) population and total live CD45+ lymphocytes. The ratio of ILC2 to ILC1 or ILC3 was varied widely and was increased in the peripheral blood of patients with type 2 diabetes.