| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The bioactive peptide angiotensin II causes hyperplasia in the zona glomerulosa of adrenal gland. Relationship between Ang II stimulation and hyperproliferation of the adrenal cells is still unclear. In this study, we showed that one of CREM isoforms inducible cAMP early repressor (ICER), which is known as a transcriptional repressor, is induced by Ang II in adrenal cell line. And ICER may be responsible for a negative feedback mechanism suppressing adrenal hyperproliferation by Ang II stimulation.
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