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Study on endocrinological mechanism underlying body weight loss and improvement of glucose metabolism after bariatric surgery model rat

Research Project

Project/Area Number 16K19553
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionUniversity of Miyazaki (2018-2019)
Kyoto University (2016-2017)

Principal Investigator

MARUYAMA KEISUKE  宮崎大学, 農学部, 准教授 (20612386)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords肥満減量手術 / 肥満減量手術モデルラット / インスリン分泌 / 膵β細胞 / ペプチドホルモン / 生理活性物質 / 減量手術モデルラット / 肥満減量手術モデル動物
Outline of Final Research Achievements

The aim of this study was to clarify the endocrinological mechanism underlying body weight loss and improvement of glucose metabolism in the bariatric surgery model rat. We established the bariatric surgery model rat (RYGB rat) using Wistar fatty rat. Body weight of the RYGB group was reduced after surgery, and maintained approximately 90% of that of the Sham group. To evaluate the insulin secretory capacity in our RYGB model rats, we performed an oral glucose tolerance test (OGTT). Blood insulin level during the OGTT was markedly higher the RYGB group compared with Sham group. In addition, our examinations suggest that GLP-1 is partially involved in the enhancement of GSIS in RYGB rat. Therefore, we attempted to identify bioactive peptides involved in the enhancement of GSIS in this model rat using RNA-seq analysis and peptide purification with Ca2+ assay system.

Academic Significance and Societal Importance of the Research Achievements

肥満減量手術に関する基礎研究により、体重減少、糖代謝改善のメカニズムを解明していくことは、急速に普及している肥満外科治療の有効性、安全性を検証し、さらなる発展を目指すうえで、決して欠かしてはならないものである。また、肥満減量手術の体重減少、糖代謝改善効果に関連した内因性因子の探索は、創薬へと繋がる可能性を秘めている。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (5 results)

  • [Journal Article] Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents2020

    • Author(s)
      Islam Md Nurul、Mita Yuichiro、Maruyama Keisuke、Tanida Ryota、Zhang Weidong、Sakoda Hideyuki、Nakazato Masamitsu
    • Journal Title

      Journal of Endocrinology

      Volume: 244 Issue: 1 Pages: 13-23

    • DOI

      10.1530/joe-19-0102

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus.2020

    • Author(s)
      2.Nakahara K, Maruyama K, Ensho T, Mori K, Miyazato M, Kangawa K, Uemura R, Sakota H, Nakazato M, and Murakami N
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 521 Issue: 2 Pages: 521-526

    • DOI

      10.1016/j.bbrc.2019.10.156

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Purification and identification of native forms of goldfish neuromedin U from brain and gut2019

    • Author(s)
      Maruyama Keisuke、Kaiya Hiroyuki、Miyazato Mikiya、Murakami Noboru、Nakahara Keiko、Matsuda Kouhei
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 517 Issue: 3 Pages: 433-438

    • DOI

      10.1016/j.bbrc.2019.07.108

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of glucose tolerance between wild-type mice and mice with double knockout of neuromedin U and neuromedin S2019

    • Author(s)
      ENSHO Takuya、MARUYAMA Keisuke、QATTALI Abdul Wahid、YASUDA Masahiro、UEMURA Ryoko、MURAKAMI Noboru、NAKAHARA Keiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 9 Pages: 1305-1312

    • DOI

      10.1292/jvms.19-0320

    • NAID

      130007708861

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuromedin U precursor-related peptide (NURP) exerts neuromedin U-like sympathetic nerve action in the rat2017

    • Author(s)
      Ensho Takuya、Maruyama Keisuke、Mori Kenji、Miyazato Mikiya、Kangawa Kenji、Nakahara Keiko、Murakami Noboru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 492 Issue: 3 Pages: 412-418

    • DOI

      10.1016/j.bbrc.2017.08.084

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] ニューロメジンS前駆体中の新規ペプチド(NSRP)の生理機能の探索2019

    • Author(s)
      田口 史門、延生 卓也、森 健二、宮里 幹也、寒川 賢治、丸山 圭介、村上 昇、中原 桂子
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肥満減量手術の動物モデルを基盤とした新規生理活性ペプチドの探索2018

    • Author(s)
      丸山圭介、宮澤崇、中尾一和、寒川賢治
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 病態モデル動物からの生理活性ペプチドの探索2016

    • Author(s)
      丸山圭介、宮澤崇、中尾一和、寒川賢治
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウンビル(東京都江東区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 肥満減量手術モデル動物からの生理活性ペプチドの探索2016

    • Author(s)
      丸山圭介、宮澤崇、中尾一和、寒川賢治
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京都江東区)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 肥満減量手術モデルラットにおけるグルコース応答性インスリン分泌の改善2016

    • Author(s)
      丸山圭介、宮澤崇、中尾一和、寒川賢治
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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