| Project/Area Number |
16K19557
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kurume University (2017)
Kyushu University (2016) |
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Principal Investigator |
Wang Lixiang 久留米大学, 医学部, 助教 (20748793)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ミトコンドリアダイナミクス / 糖脂質代謝 / 炎症反応 / オートファジー / 活性酸素 / 代謝 / 炎症 / 炎症制御 / 糖・脂質代謝 / 小胞体ストレス / オートファージ |
|---|
| Outline of Final Research Achievements |
Mitochondria are highly dynamic organelles that frequently fuse and divide in response to cellular energy demands, differentiation or pathological conditions. In vertebrates, dynamin-related protein 1 (DRP1) and mitochondrial fission factor control mitochondrial fission. In our previous study, by using liver specific DRP1 knockout (Drp1LiKO) mice, we reported that a defect in mitochondrial fission showed a protective role against diabetes and obesity. On the other hand, histological analysis revealed that Drp1LiKO liver exhibited severe inflammation and fibrosis, reminiscences of nonalcoholic steatohepatitis. Currently, we found that inflammatory cytokines were markedly increased in Drp1LiKO liver, possibly associated with the defective autophagic degradation and increased reactive oxygen species (ROS) generation. Thus, our results provide new insight into the role of mitochondrial dynamics in inflammasome activation.
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