Integrative Medicice Focused on the Receptor Biniding Molecule for Obesity and Metabolic Syndrome
| Project/Area Number |
16K19558
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Yokohama City University |
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Principal Investigator |
Kengo AZUSHIMA 横浜市立大学, 医学研究科, 客員研究員 (00760381)
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| Research Collaborator |
TAMURA Kouichi
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪細胞 / 骨格筋 / インスリン抵抗性 / 肥満症 / 受容体 / レニン-アンジオテンシン系 / 脂肪組織 / 肥満 / 内科 / メタボリック症候群 / 統合医療 |
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| Outline of Final Research Achievements |
Angiotensin II type 1 receptor (AT1R) is a major player in the signal transduction of renin-angiotensin system, and the overactivation of this signaling contributes to the progression of visceral obesity. AT1R-associated protein (ATRAP) promotes AT1R internalization along with the suppression of overactivation of tissue AT1R signaling. We demonstrated that the enhancement of ATRAP in adipose tissue ameliorated high-fat diet-induced visceral obesity and insulin resistance via the attenuation of overactivated AT1R signaling and adipose inflammation. Furthermore, we revealed that low-dose angiotensin II administration could promote the insulin resistance even in a lean type, and this finding was mainly caused by the dysfunction of glucose uptake in skeletal muscle due to increased oxidative stress. The enhancement of ATRAP in skeletal muscle ameliorated this insulin resistance in a lean type via the attenuation of overactivated AT1R signaling and oxidative stress in skeletal muscle.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice2017
Author(s)
Wakui H, Ohki K, Azushima K, Uneda K, Haku S, Kobayashi R, Haruhara K, Kinguchi S, Matsuda M, Ohsawa M, Maeda A, Minegishi S, Ishigami T, Toya Y, Yamashita A, Umemura S, Tamura K
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Journal Title
International Journal of Molecular Sciences
Volume: 18
Issue: 3
Pages: 676-676
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Adipocyte-Specific Enhancement of Angiotensin II Type 1 Receptor-Associated Protein Ameliorates Diet-Induced Visceral Obesity and Insulin Resistance.2017
Author(s)
Azushima K, Ohki K, Wakui H, Uneda K, Haku S, Kobayashi R, Haruhara K, Kinguchi S, Matsuda M, Maeda A, Toya Y, Yamashita A, Umemura S, Tamura K.
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Journal Title
J Am Heart Assoc.
Volume: 6
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Adipocyte angiotensin II type 1 receptor (AT1R)-associated protein prevents diet-induced visceral obesity and insulin resistance through the suppression of overactivated tissue AT1R signaling2018
Author(s)
Azushima K, Wakui H, Uneda K, Kobayashi R, Haku S, Ohki K, Haruhara K, Kinguchi S, Yamashita A, Umemura S, Tamura K
Organizer
ISN Frontiers Meetings 2018
Related Report
Int'l Joint Research
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[Presentation] The Protective Role of Angiotensin II Type 1 Receptor Associated Protein in Metabolic Disorders2018
Author(s)
Kohji Ohki, Hiromichi Wakui, Kengo Azushima, Kazushi Uneda, Ryu kobayashi, Sona Haku, Kotaro Haruhara, Sho Kinguchi, Takayuki Yamada, Takahiro Yamaji, Nozomu Kishio, Kento Imajo Atsushi Nakajima, Akio Yamashita, Yoshiyuki Toya and Kouichi Tamura
Organizer
ISN Frontiers Meetings 2018
Related Report
Int'l Joint Research
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[Presentation] 糖脂質代謝障害における1型アンジオテンシンII受容体結合蛋白ATRAPの機能的意義2017
Author(s)
大城 光二，涌井広道, 大澤正人, 小豆島健護, 畝田一司, 小林竜, 白善雅, 春原浩太郎, 金口翔, 山田貴之, 山地孝拡, 松田美由紀, 岸尾望, 今城健人, 中島淳, 山下暁朗, 戸谷義幸, 田村功一
Organizer
第21回心血管内分泌代謝学会学術総会
Related Report
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