The association between serum macro TSH Level and sleep disorder

• Project/Area Number: 16K19562
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Hyogo Medical University
• Principal Investigator: Kadoya Manabu 兵庫医科大学, 医学部, 助教 (90755109)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: マクロTSH / 睡眠障害 / HSCAA研究

Outline of Final Research Achievements

We investigated structural differences between serum macro TSH and free TSH and the association of macro TSH with sleep quality in humans. In results, increase in serum macro TSH levels is associated with low sleep quality and is regulated in a distinct fashion from free TSH potentially due to an altered glycosylation structure. We showed the possibility that macro TSH was a marker of sleep dysorder.

Research Products

• [Journal Article] Serum Macro TSH level is associated with sleep quality in patients with cardiovascular risks: HSCAA Study. (2017)
  • Author(s): Kadoya M Koyama S, Morimoto A, Miyoshi A, Kakutani M, Hamamoto K, Kurajoh M, Shoji T, Moriwaki Y, Koshiba M, Yamamoto T, Inaba M, Namba M, Koyama H
  • Journal Title: Scientifi Report Volume: 7 Issue: 1 Pages: 44387-44387
  • DOI: 10.1038/srep44387
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] マクロTSHは血糖変動と関連し2型糖尿病で上昇する-HSCAA研究- (2016)
  • Author(s): 角谷学、小山英則、森本晶子、中 真理子、三好晶雄、角谷美樹、濱本佳恵、藏城雅文、庄司拓仁、小柴賢洋、森脇優司、難波光義．
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都国際会議場(京都府、京都市）
• [Presentation] ヒトにおけるマクロTSHと睡眠障害に関する検討 (2016)
  • Author(s): 角谷学、小山英則、森本晶子、中 真理子、三好晶雄、角谷美樹、濱本佳恵、藏城雅文、庄司拓仁、小柴賢洋、森脇優司、難波光義．
  • Organizer: 第89回日本内分泌学会年次学術集会
  • Place of Presentation: 京都国際会議場(京都府、京都市)