Mucosal-associated invariant T (MAIT) cell after allogeneic hematopoietic cell transplantation

• Project/Area Number: 16K19570
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: Konuma Takaaki 東京大学, 医科学研究所, 助教 (00709553)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 同種造血細胞移植 / 臍帯血移植 / MAIT細胞 / 慢性移植片対宿主病 / 免疫再構築 / 移植片対宿主病 / 免疫不全

Outline of Final Research Achievements

Mucosal-associated invariant T (MAIT) cells are abundant in peripheral blood T-cell subset, and may play a key role in antibacterial and antiviral immunity, and autoimmunity, which resembles the main clinical features after allogeneic hematopoietic cell transplantation (HCT). Here, we examined the numbers and the proportions of MAIT cells in 173 patients without disease recurrence at least 10 months after undergoing allogeneic HCT. The proportions of MAIT cells among CD3+T-cells were significantly lower in patients that received cord blood transplantation (CBT) and related bone marrow transplantation compared with the control group. The number of MAIT cells was significantly correlated with the months only after CBT. Patients with chronic graft-versus-host disease (cGVHD) had a significantly lower frequency of MAIT cells compared with patients without cGVHD. MAIT-like cells with cGVHD did not show altered functional ability to produce IL-17, IFN-γ, Granzyme-B after stimulation.

Research Products

• [Journal Article] Allogeneic hematopoietic cell transplantation for adult acute myeloid leukemia in second remission: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) (2018)
  • Author(s): Takaaki Konuma, Masamitsu Yanada, Satoshi Yamasaki, Yachiyo Kuwatsuka, Takahiro Fukuda, Takeshi Kobayashi, Yukiyasu Ozawa, Naoyuki Uchida, Shuichi Ota, Takumi Hoshino, Satoshi Takahashi, Yoshinobu Kanda, Yasunori Ueda, Minoko Takanashi, Junya Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Shingo Yano
  • Journal Title: British Journal of Haematology Volume: In press Pages: 1-2
  • Peer Reviewed
• [Journal Article] Does marital status affect the outcomes after allogeneic hematopoietic cell transplantation? (2018)
  • Author(s): Tomoko Sato, Takaaki Konuma, Maki Oiwa-Monna, Susumu Tanoue, Masamichi Isobe, Koji Jimbo, Fumiko Kasuya, Minayo Hisahara, Koji Kobayashi, Seiko Kato, Satoshi Takahashi, Arinobu Tojo
  • Journal Title: Bone Marrow Transplantation Volume: In press Pages: 1-2
  • Peer Reviewed
• [Journal Article] Circulating monocyte subsets in human chronic graft-versus-host disease (2018)
  • Author(s): Konuma Takaaki、Kohara Chisato、Watanabe Eri、Mizukami Motoko、Nagai Etsuko、Oiwa-Monna Maki、Tanoue Susumu、Isobe Masamichi、Koji Jimbo、Kato Seiko、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: Bone Marrow Transplantation Volume: In press Pages: 1-2
  • Peer Reviewed
• [Journal Article] Azacitidine effectively reduces TP53-mutant leukemic cell burden in secondary acute myeloid leukemia after cord blood transplantation (2018)
  • Author(s): Takei Tomomi、Yokoyama Kazuaki、Shimizu Eigo、Konuma Takaaki、Takahashi Satoshi、Yamaguchi Rui、Imoto Seiya、Miyano Satoru、Tojo Arinobu
  • Journal Title: Leukemia & Lymphoma Volume: In press Issue: 11 Pages: 1-2
  • DOI: 10.1080/10428194.2018.1443335
  • Peer Reviewed
• [Journal Article] Monocyte subsets and their phenotypes during treatment with BCR-ABL1 tyrosine kinase inhibitors for Philadelphia chromosome-positive leukemia (2018)
  • Author(s): Konuma Takaaki、Kohara Chisato、Watanabe Eri、Mizukami Motoko、Nagai Etsuko、Tanoue Susumu、Isobe Masamichi、Jimbo Koji、Kato Seiko、Ohno Nobuhiro、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: Hematological Oncology Volume: 36 Issue: 2 Pages: 451-456
  • DOI: 10.1002/hon.2497
  • Peer Reviewed
• [Journal Article] A cross-sectional study on late taste disorders in survivors of allogeneic hematopoietic cell transplantation (2017)
  • Author(s): Sato Tomoko、Konuma Takaaki、Miwa Yoriko、Sugihara Nozomi、Tsuru Yukari、Narita Hatsuko、Kiriyama Satomi、Kato Seiko、Oiwa-Monna Maki、Kobayashi Koji、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: Annals of Hematology Volume: 96 Issue: 11 Pages: 1841-1847
  • DOI: 10.1007/s00277-017-3087-6
  • Peer Reviewed
• [Journal Article] Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients (2017)
  • Author(s): Konuma Takaaki、Kohara Chisato、Watanabe Eri、Mizukami Motoko、Nagai Etsuko、Oiwa-Monna Maki、Tanoue Susumu、Isobe Masamichi、Kato Seiko、Tojo Arinobu、Takahashi Satoshi
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 23 Issue: 11 Pages: 1932-1938
  • DOI: 10.1016/j.bbmt.2017.07.020
  • Peer Reviewed
• [Journal Article] Risk factors and characteristics of falls among hospitalized adult patients with hematologic diseases (2017)
  • Author(s): Miwa Yoriko、Yamagishi Yasuko、Konuma Takaaki、Sato Tomoko、Narita Hatsuko、Kobayashi Koji、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: Journal of Geriatric Oncology Volume: 8 Issue: 5 Pages: 363-367
  • DOI: 10.1016/j.jgo.2017.07.003
  • Peer Reviewed
• [Journal Article] Alloimmune hemolysis due to major RhE incompatibility after unrelated cord blood transplantation (2017)
  • Author(s): Isobe Masamichi、Konuma Takaaki、Abe-Wada Yuka、Hirata Kyoko、Ogami Kazuo、Kato Seiko、Oiwa-Monna Maki、Tanoue Susumu、Nagamura-Inoue Tokiko、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: Leukemia & Lymphoma Volume: 59 Issue: 4 Pages: 1000-1003
  • DOI: 10.1080/10428194.2017.1352095
  • Peer Reviewed
• [Journal Article] Severe infusion-related toxicity after a second unrelated cord blood transplantation (2017)
  • Author(s): Tanoue Susumu、Konuma Takaaki、Kato Seiko、Oiwa-Monna Maki、Isobe Masamichi、Tojo Arinobu、Takahashi Satoshi
  • Journal Title: Cytotherapy Volume: 19 Issue: 8 Pages: 1013-1014
  • DOI: 10.1016/j.jcyt.2017.05.004
  • Peer Reviewed
• [Journal Article] Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia (2017)
  • Author(s): Hattori Ayuna、Tsunoda Makoto、Konuma Takaaki、Kobayashi Masayuki、Nagy Tamas、Glushka John、Tayyari Fariba、McSkimming Daniel、Kannan Natarajan、Tojo Arinobu、Edison Arthur S.、Ito Takahiro
  • Journal Title: Nature Volume: 545 Issue: 7655 Pages: 500-504
  • DOI: 10.1038/nature22314
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long-term persistent donor?recipient mixed chimerism without disease recurrence after myeloablative single-unit cord blood transplantation in adult acute myeloid leukemia following myelodysplastic syndrome (2017)
  • Author(s): Tanoue Susumu、Konuma Takaaki、Takahashi Satoshi、Watanabe Eri、Sato Natsuko、Watanabe Nobukazu、Isobe Masamichi、Kato Seiko、Ooi Jun、Tojo Arinobu
  • Journal Title: Leukemia & Lymphoma Volume: 58 Issue: 12 Pages: 2973-2975
  • DOI: 10.1080/10428194.2017.1318440
  • Peer Reviewed
• [Journal Article] Cryopreserved CD34+ Cell Dose, but Not Total Nucleated Cell Dose, Influences Hematopoietic Recovery and Extensive Chronic GVHD after Single-Unit Cord Blood Transplantation in Adult Patients. (2017)
  • Author(s): Konuma T, Kato S, Oiwa-Monna M, Tanoue S, Ogawa M, Isobe M, Tojo A, Takahashi S.
  • Journal Title: Biol Blood Marrow Transplant Volume: In press Issue: 7 Pages: 1142-1150
  • DOI: 10.1016/j.bbmt.2017.03.036
  • Peer Reviewed
• [Journal Article] Serum C-reactive protein levels affect the plasma voriconazole trough levels in allogeneic hematopoietic cell transplant recipients. (2017)
  • Author(s): Yasu T, Konuma T, Kato S, Kurokawa Y, Takahashi S, Tojo A.
  • Journal Title: Leuk Lymphoma Volume: In press Issue: 11 Pages: 2731-2733
  • DOI: 10.1080/10428194.2017.1300897
  • Peer Reviewed
• [Journal Article] Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia harboring trisomy 8. (2017)
  • Author(s): Konuma T, Kondo T, Yamashita T, Uchida N, Fukuda T, Ozawa Y, Ohashi K, Ogawa H, Kato C, Takahashi S, Kanamori H, Eto T, Nakaseko C, Kohno A, Ichinohe T, Atsuta Y, Takami A, Yano S
  • Journal Title: Ann Hematol Volume: 96 Issue: 3 Pages: 469-478
  • DOI: 10.1007/s00277-016-2909-2
  • Peer Reviewed
• [Journal Article] Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Myelodysplastic Syndrome Harboring Trisomy 8. (2017)
  • Author(s): Konuma T, Miyazaki Y, Uchida N, Ohashi K, Kondo T, Nakamae H, Takahashi S, Mori T, Ozawa Y, Kato C, Iwato K, Fukuda T, Ichinohe T, Atsuta Y, Ishiyama K
  • Journal Title: Biol Blood Marrow Transplant Volume: 23 Issue: 1 Pages: 75-80
  • DOI: 10.1016/j.bbmt.2016.10.015
  • Peer Reviewed
• [Journal Article] Breakthrough fungemia due to Candida fermentati with fks1p mutation under micafungin treatment in a cord blood transplant recipient. (2017)
  • Author(s): Konuma T, Takahashi S, Kiyuna T, Miharu Y, Suzuki M, Shibata H, Kato S, Takahashi S, Tojo A.
  • Journal Title: Transpl Infect Dis Volume: 19 Issue: 1 Pages: 1-1
  • DOI: 10.1111/tid.12634
  • Peer Reviewed
• [Journal Article] Impact of hematogones on the long-term outcomes of single-unit cord blood transplantation for adult patients. (2017)
  • Author(s): Ishii H, Konuma T, Kato S, Oiwa-Monna M, Tojo A, Takahashi S.
  • Journal Title: Leuk Lymphoma Volume: 58 Issue: 1 Pages: 118-126
  • DOI: 10.1080/10428194.2016.1180687
  • Peer Reviewed
• [Journal Article] CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. (2016)
  • Author(s): Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T.
  • Journal Title: Cancer Cell Volume: 30 Issue: 5 Pages: 792-805
  • DOI: 10.1016/j.ccell.2016.10.003
  • Peer Reviewed
• [Journal Article] Different effects of lansoprazole and rabeprazole on the plasma voriconazole trough levels in allogeneic hematopoietic cell transplant recipients. (2016)
  • Author(s): Yasu T, Konuma T, Kato S, Kurokawa Y, Takahashi S, Tojo A.
  • Journal Title: Ann Hematol Volume: 95 Issue: 11 Pages: 1845-1851
  • DOI: 10.1007/s00277-016-2782-z
  • Peer Reviewed
• [Journal Article] Multi-locus sequence analysis for identification of Achromobacter xylosoxidans from blood culture. (2016)
  • Author(s): Takei T, Konuma T, Takahashi S, Miharu Y, Suzuki M, Shibata H, Ishii H, Kato S, Takahashi S, Tojo A.
  • Journal Title: Infect Dis (Lond) Volume: 48 Issue: 11-12 Pages: 864-866
  • DOI: 10.1080/23744235.2016.1203987
  • Peer Reviewed
• [Journal Article] Early phase mixed chimerism in bone marrow does not affect long-term outcomes of myeloablative single-unit cord blood transplantation for adult patients with hematological malignancies. (2016)
  • Author(s): Konuma T, Kato S, Oiwa-Monna M, Ishii H, Tojo A, Takahashi S.
  • Journal Title: Leuk Lymphoma Volume: 57 Issue: 12 Pages: 2848-2854
  • DOI: 10.3109/10428194.2016.1171860
  • Peer Reviewed
• [Journal Article] Comparison of transplant outcomes from matched sibling bone marrow or peripheral blood stem cell and unrelated cord blood in patients 50 years or older. (2016)
  • Author(s): Konuma T, Tsukada N, Kanda J, Uchida N, Ohno Y, Miyakoshi S, Kanamori H, Hidaka M, Sakura T, Onizuka M, Kobayashi N, Sawa M, Eto T, Matsuhashi Y, Kato K, Ichinohe T, Atsuta Y, Miyamura K
  • Journal Title: Am J Hematol Volume: 91 Issue: 5
  • DOI: 10.1002/ajh.24340
  • Peer Reviewed
• [Journal Article] Comparison of graft-versus-host disease-free, relapse-free survival of transplantation using matched sibling donor, matched unrelated donor or unrelated cord blood after myeloablative conditioning for adult patients with hematological malignancies. (2016)
  • Author(s): Konuma T, Kato S, Oiwa-Monna M, Ishii H, Tojo A, Takahashi S.
  • Journal Title: Leuk Lymphoma Volume: 57 Issue: 9 Pages: 2126-2132
  • DOI: 10.3109/10428194.2015.1122784
  • Peer Reviewed
• [Presentation] 骨髄異形成症候群や骨髄増殖性腫瘍に対する同種造血細胞移植 (2018)
  • Author(s): 小沼貴晶
  • Organizer: 第40回造血細胞移植学会
  • Invited
• [Presentation] 臍帯血移植の移植前処置 (2018)
  • Author(s): 小沼貴晶
  • Organizer: 第40回造血細胞移植学会
• [Presentation] 成人臍帯血移植における血小板輸血不応に影響する因子と臨床転帰 (2018)
  • Author(s): 田上晋、小沼貴晶、加藤せい子、大岩真希、磯部優理、神保光児、高橋聡、東條有伸
  • Organizer: 第40回造血細胞移植学会
• [Presentation] 成人臍帯血移植における生着前症候群及び急性移植片対宿主病が移植成績に及ぼす影響 (2018)
  • Author(s): 磯部優理、小沼貴晶、加藤せい子、大岩真希、田上晋、神保光児、高橋聡、東條有伸
  • Organizer: 第40回造血細胞移植学会
• [Presentation] 慢性移植片対宿主病における末梢血単球各サブセットにおける表面マーカー解析 (2018)
  • Author(s): 小沼貴晶、小原千聖、渡辺恵理、水上素子、永井悦子、加藤せい子、大岩真希、田上晋、磯部優理、神保光児、高橋聡、東條有伸
  • Organizer: 第40回造血細胞移植学会
• [Presentation] 移植時婚姻状況は同種造血細胞移植における移植成績に影響を与えるか？ (2018)
  • Author(s): 佐藤朋子、小沼貴晶、大岩真希、田上晋、磯部優理、神保光児、粕谷文子、久原みな代、小林康司、加藤せい子、高橋聡、東條有伸
  • Organizer: 第40回造血細胞移植学会
• [Presentation] 成人臍帯血移植後の再入院が移植成績に与える影響 (2018)
  • Author(s): 山岸康子、小沼貴晶、三輪依子、大岩真希、田上晋、磯部優理、神保光児、成田初子、小林康司、加藤せい子、高橋聡、東條有伸
  • Organizer: 第40回造血細胞移植学会
• [Presentation] 臍帯血移植後に発症し長期間持続した短期記憶障害を伴う中枢神経合併症 (2018)
  • Author(s): 加藤せい子、小沼貴晶、大岩真希、田上晋、磯部優理、神保光児、水澤舞、 高橋聡、東條 有伸
  • Organizer: 第40回造血細胞移植学会
• [Presentation] トリソミー8を含む骨髄異形成症候群の 同種造血細胞移植における予後因子解析： 成人骨髄異形成症候群WG研究 (2017)
  • Author(s): 小沼貴晶、宮﨑泰司、内田直之、大橋一輝、近藤忠一、中前博久、高橋聡、森毅彦、小澤幸泰、加藤千明、岩戸康治、福田隆浩、 一戸辰夫、熱田由子、石山謙
  • Organizer: 第39回日本造血細胞移植学会
  • Place of Presentation: くにびきメッセ
  • Year and Date: 2017-03-02
• [Presentation] 同種造血細胞移植症例におけるC反応性蛋白値のボリコナゾールトラフ濃度への影響 (2017)
  • Author(s): 安武夫、小沼貴晶、加藤せい子、黒川陽介、高橋聡、東條有伸
  • Organizer: 第39回日本造血細胞移植学会
  • Place of Presentation: くにびきメッセ
  • Year and Date: 2017-03-02
• [Presentation] 血液内科病棟における転倒に関する後方視的研究 (2017)
  • Author(s): 三輪依子、山岸康子、小沼貴晶、高橋聡、東條有伸、佐藤朋子、成田初子、小林康司
  • Organizer: 第39回日本造血細胞移植学会
  • Place of Presentation: くにびきメッセ
  • Year and Date: 2017-03-02
• [Presentation] 同種造血細胞移植後患者の味覚障害に関する横断的研究 (2017)
  • Author(s): 佐藤朋子、小沼貴晶、加藤せい子、大岩真希、高橋聡、東條有伸、三輪依子、杉原望、都留由香里、成田初子、桐山里美、小林康司
  • Organizer: 第39回日本造血細胞移植学会
  • Place of Presentation: くにびきメッセ
  • Year and Date: 2017-03-02
• [Presentation] 成人臍帯血移植における生着前症候群のサイトカインプロファイル (2017)
  • Author(s): Takaaki Konuma, Chisato Kohara, Eri Watanabe, Motoko Mizukami, Etsuko Nagai, Maki Oiwa-Monna, Seiko Kato, Arinobu Tojo, and Satoshi Takahashi.
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] ２回目の非血縁者間臍帯血移植で認められた重症輸注毒性 (2017)
  • Author(s): Susumu Tanoue, Seiko Kato, Takaaki Konuma, Maki Oiwa-Monna, Masamichi Isobe, Arinobu Tojo, and Satoshi Takahashi
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] RhE不適合が原因と考えられた非血縁者間同種臍帯血移植後に溶血を認めた1例 (2017)
  • Author(s): Masamichi Isobe, Takaaki Konuma, Yuka Abe-Wada, Kyoko Hirata, Kazuo Ogami, Seiko Kato, Maki Oiwa-Monna, Susumu Tanoue, Tokiko Nagamura-Inoue, Satoshi Takahashi, and Arinobu Tojo
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] 造血器腫瘍症例におけるボリコナゾール静注製剤による腎機能への影響 (2017)
  • Author(s): 安武夫，小沼貴晶，黒田誠一郎，高橋聡，東條有伸
  • Organizer: 第27回日本医療薬学会
• [Presentation] Personalized Circulating Tumor DNA Predicts Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome (2017)
  • Author(s): Sousuke Nakamura, Kazuaki Yokoyama, Nozomi Yusa, Miho Ogawa, Tomomi Takei, Asako Kobayashi, Mika Ito, Masayuki Kobayashi, Koji Jimbo, Susumu Tanoue, Masamichi Isobe, Takaaki Konuma, et al.
  • Organizer: 59th ASH Annual Meeting & Exposition
• [Presentation] Single-unit cord blood transplantation for adults using low cryopreserved nucleated cell number (2016)
  • Author(s): Konuma T, Kato S, Oiwa M, Tojo A, Takahashi S.
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-13
• [Presentation] Reduced toxicity myeloablative conditioning in CBT for elderly patients with advanced MDS and AML (2016)
  • Author(s): Konuma T, Kato S, Oiwa M, Tojo A, Takahashi S.
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-13