| Project/Area Number |
16K19571
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAJITA Mihoko 東京医科歯科大学, 難治疾患研究所, 特任助教 (00607442)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | dendritic cells / WSX-1 / WSX1 / interferon gamma / 免疫学 / 樹状細胞 / IL-27 |
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| Outline of Final Research Achievements |
In mice deficient for WSX-1, which is a component of IL-27 receptor, the number of dendritic cells (DCs) substantially decreased in lymphoid tissues and the mice developed systemic autoimmune diseases with age (Kajita et al. unpublished data). In this study, I found that DC development in the bone marrow culture was profoundly suppressed in aged WSX-1-deficient mice compared with young WSX-1-deficient mice. Moreover, IFN-γ treatment of bone marrow cells inhibited Flt3-induced DC development. IFN-γ treatment also suppressed Flt3 expression on the lineage negative cells in vitro. These data suggest that in aged WSX-1-deficient mice, the reduction of DCs in lymphoid tissues is caused by the aberrant development of DCs.
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