Elucidation of the molecular mechanism of megakaryocyte-lineage differentiation focusing on lncRNAs

• Project/Area Number: 16K19578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Kyushu University
• Principal Investigator: Miyawaki Kohta 九州大学, 大学病院, 助教 (50774709)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 巨核球 / 前駆細胞 / 巨核球前駆細胞 / 巨核球分化 / 巨核球系前駆細胞 / long non-coding RNA / 転写因子 / 造血幹細胞 / 分化機構 / 骨髄増殖性腫瘍 / 巨核球系分化

Outline of Final Research Achievements

Recent studies revealed that platelets and megakaryocytes contribute not only to hemostasis but also to various pathological conditions including cardio-vascular diseases, inflammatory diseases, and tumors. However, the development pathway for megakaryocyte- and platelet-lineage has been poorly understood, especially in human hematopoiesis. In the present study, we first identified prospectively-isolatable and functionally homogeneous human megakaryocyte progenitor residing near hematopoietic stem cells in human adult bone marrow. This newly-identified unipotent megakaryocyte progenitor significantly contributes normal megakaryopoiesis and pathogenesis of hematologic malignancies such as myeloproliferative diseases.

Research Products

• [Journal Article] Identification of unipotent megakaryocyte progenitors in human hematopoiesis. (2017)
  • Author(s): K. Miyawaki. Iwasaki, T. Jiromaru, H. Kusumoto, A. Yurino, T. Sugio, Y. Uehara, J. Odawara, S. Daitoku, Y. Kunisaki, Y. Mori, Y. Arinobu, H. Tsuzuki, Y. Kikushige, T. Iino, K. Kato, K. Takenaka, T. Miyamoto, T. Maeda, *K. Akashi
  • Journal Title: Blood Volume: 印刷中 Issue: 25 Pages: 3332-3343
  • DOI: 10.1182/blood-2016-09-741611
  • Peer Reviewed / Open Access / Acknowledgement Compliant