| Project/Area Number |
16K19578
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 巨核球 / 前駆細胞 / 巨核球前駆細胞 / 巨核球分化 / 巨核球系前駆細胞 / long non-coding RNA / 転写因子 / 造血幹細胞 / 分化機構 / 骨髄増殖性腫瘍 / 巨核球系分化 |
|---|
| Outline of Final Research Achievements |
Recent studies revealed that platelets and megakaryocytes contribute not only to hemostasis but also to various pathological conditions including cardio-vascular diseases, inflammatory diseases, and tumors. However, the development pathway for megakaryocyte- and platelet-lineage has been poorly understood, especially in human hematopoiesis. In the present study, we first identified prospectively-isolatable and functionally homogeneous human megakaryocyte progenitor residing near hematopoietic stem cells in human adult bone marrow. This newly-identified unipotent megakaryocyte progenitor significantly contributes normal megakaryopoiesis and pathogenesis of hematologic malignancies such as myeloproliferative diseases.
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