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Elucidation of the molecular mechanism of megakaryocyte-lineage differentiation focusing on lncRNAs

Research Project

Project/Area Number 16K19578
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKyushu University

Principal Investigator

Miyawaki Kohta  九州大学, 大学病院, 助教 (50774709)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords巨核球 / 前駆細胞 / 巨核球前駆細胞 / 巨核球分化 / 巨核球系前駆細胞 / long non-coding RNA / 転写因子 / 造血幹細胞 / 分化機構 / 骨髄増殖性腫瘍 / 巨核球系分化
Outline of Final Research Achievements

Recent studies revealed that platelets and megakaryocytes contribute not only to hemostasis but also to various pathological conditions including cardio-vascular diseases, inflammatory diseases, and tumors. However, the development pathway for megakaryocyte- and platelet-lineage has been poorly understood, especially in human hematopoiesis. In the present study, we first identified prospectively-isolatable and functionally homogeneous human megakaryocyte progenitor residing near hematopoietic stem cells in human adult bone marrow. This newly-identified unipotent megakaryocyte progenitor significantly contributes normal megakaryopoiesis and pathogenesis of hematologic malignancies such as myeloproliferative diseases.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Identification of unipotent megakaryocyte progenitors in human hematopoiesis.2017

    • Author(s)
      K. Miyawaki. Iwasaki, T. Jiromaru, H. Kusumoto, A. Yurino, T. Sugio, Y. Uehara, J. Odawara, S. Daitoku, Y. Kunisaki, Y. Mori, Y. Arinobu, H. Tsuzuki, Y. Kikushige, T. Iino, K. Kato, K. Takenaka, T. Miyamoto, T. Maeda, *K. Akashi
    • Journal Title

      Blood

      Volume: 印刷中 Issue: 25 Pages: 3332-3343

    • DOI

      10.1182/blood-2016-09-741611

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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