| Project/Area Number |
16K19585
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Fukuda Yuri 和歌山県立医科大学, 医学部, 特別研究員 (40770847)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 樹状細胞 / サブセット / 遺伝子改変マウス / 移植片対宿主病 / 抗体 / 移植 / 細胞傷害性T細胞 |
|---|
| Outline of Final Research Achievements |
I have investigated whether or how pathogenesis of graft versus host diseases (GVHD) depends on a dendritic cell subset, XCR1+DC, which is known to be involved in activation of cytotoxic T cells. First, I established the analyzing system for GVHD. Then by utilizing control or XCR1-DTA mice, in which XCR1+DCs are constitutively ablated, I have found that donor-derived XCR1+DCs are involved in pathogenesis of GVHD.
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