Functions of dendritic cell subsets in graft versus host diseases
Project/Area Number |
16K19585
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Wakayama Medical University |
Principal Investigator |
Fukuda Yuri 和歌山県立医科大学, 医学部, 特別研究員 (40770847)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 樹状細胞 / サブセット / 遺伝子改変マウス / 移植片対宿主病 / 抗体 / 移植 / 細胞傷害性T細胞 |
Outline of Final Research Achievements |
I have investigated whether or how pathogenesis of graft versus host diseases (GVHD) depends on a dendritic cell subset, XCR1+DC, which is known to be involved in activation of cytotoxic T cells. First, I established the analyzing system for GVHD. Then by utilizing control or XCR1-DTA mice, in which XCR1+DCs are constitutively ablated, I have found that donor-derived XCR1+DCs are involved in pathogenesis of GVHD.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.2016
Author(s)
Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T.
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Journal Title
Scientific Reports
Volume: 162
Issue: 1
Pages: 23505-23505
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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