Development of iPSC-based CTL therapy for HTLV-1 infection
| Project/Area Number |
16K19590
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TEZUKA Kenta 国立感染症研究所, 血液・安全性研究部, 研究員 (10754533)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HTLV-1 感染症 / 発症高リスク群 / Tax特異的CTL / iPS細胞 / HTLV-1 / 感染症 / 移植・再生医療 / 免疫学 / ウイルス |
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| Outline of Final Research Achievements |
Toward achievement of the HTLV-1 prophylaxis and cure strategy, I assessed the potential for using induced pluripotent stem (iPS) cell technology for development of a new immunotherapy. The frequency of Tax-specific CTLs was quite low, and its phenotypes showed senescent, less survival, and dysfunctional behaviors in a portion of chronic HTLV-1 carriers with high proviral load (4% > PVL). Patient-derived HTLV-1-specific regenerated CTL therapy could be a promising strategy to prevent or treat HTLV-1-associated diseases among these carriers.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Establishment of a reference material for standardization of the anti-complementary activity test in intravenous immunoglobulin products used in Japan: A collaborative study.2017
Author(s)
Kiyoko Nojima, Kazu Okuma, Masaki Ochiai, Madoka Kuramitsu, Kenta Tezuka, Mieko Ishii, Sadao Ueda, Takashi Miyamoto, Koichiro Kamimura, Enki Kou,
Sanae Uchida, Yoshiharu Watanabe, Yoshiaki Okada, Isao Hamaguchi
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Journal Title
Biologicals
Volume: 46
Pages: 68-73
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of a novel dengue virus serotype-specific multiplex real-time reverse transcription-polymerase chain reaction assay for blood screening.2016
Author(s)
Kenta Tezuka, Madoka Kuramitsu, Kazu Okuma, Kiyoko Nojima, Kumiko Araki, Naoya Shinohara, Chieko Matsumoto, Masahiro Satake, Tomohiko Takasaki, Masayuki Saijo, Ichiro Kurane, and Isao Hamaguchi
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Journal Title
Transfusion
Volume: 56
Issue: 12
Pages: 3094-100
DOI
Related Report
Peer Reviewed
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