Elucidation of pathophysiology of fibrosis and sclerosis and establishment of treatment in IgG4-related disease using model mouse

• Project/Area Number: 16K19597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kanazawa University
• Principal Investigator: Mizushima Ichiro 金沢大学, 附属病院, 特任助教 (50645124)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: IgG4関連疾患 / 線維化 / モデルマウス / IgG4関連子癇 / 線維化・硬化

Outline of Final Research Achievements

In this study, using human specimens from affected organs and LAT Y136F knock-in mouse as model mouse, we investigated pathophysiology of fibrosis and sclerosis in IgG4-related disease (IgG4-RD). We have clarified the differences of types of collagen according to the anatomical locations and increase of fibril-forming collagens (collagen I and III) in parallel with progression of fibrosis and sclerosis. We have also clarified that M2 macrophages, that are implicated in fibrosis in IgG4-RD, produce APRIL promoting activation, proliferation, and survival of B lymphocytes and plasma cells, and contribute to the formation of characteristic pathology. In LAT Y136F knock-in mouse, we have found an increase of fibrosis score as mouse got older and enhanced expression of APRIL in affected organs.

Academic Significance and Societal Importance of the Research Achievements

IgG4関連疾患は原因不明の全身性炎症性疾患であり、組織学的に特異な線維化・硬化を呈し、それに伴い長期的には不可逆的な機能障害を呈する。ヒトIgG4関連疾患組織検体において、同じ臓器内においても血管周囲や腎皮質などの解剖学的部位により線維化・硬化を形成するコラーゲンのタイプが異なること、また病態の進展により線維性コラーゲンが増加してくることから、病変、病期にあわせて線維化・硬化の治療標的が異なることが示唆された。また、モデルマウスであるLAT Y136変異マウスの病変局所において、線維化の進展、ヒトと共通するサイトカインの産生亢進が確認され、本マウスを用いた更なる検討の妥当性が示唆された。

Research Products

• [Journal Article] Different factors underlie recurrent and de novo organ involvement in immunoglobulin G4-related disease. (2020)
  • Author(s): Mizushima I, Tsuge S, Fujisawa Y, Hara S, Suzuki F, Ito K, Fujii H, Yamada K, Kawano M.
  • Journal Title: Rheumatology (Oxford). Volume: 59 Pages: 513-518
  • DOI: 10.1093/rheumatology/kez321
  • Peer Reviewed / Open Access
• [Journal Article] The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease. (2020)
  • Author(s): Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Zen Y, Stone JH, et al.; American College of Rheumatology/European League Against Rheumatism IgG4-Related Disease Classification Criteria Working Group.
  • Journal Title: Arthritis & Rheumatology Volume: 72 Issue: 1 Pages: 7-19
  • DOI: 10.1002/art.41120
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease. (2020)
  • Author(s): Wallace ZS, Naden RP, Chari S, Choi HK, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Schleinitz N, Takahashi N, Umehara H, Zen Y, Stone JH; Members of the ACR/EULAR IgG4-RD Classification Criteria Working Group.
  • Journal Title: Annals of the Rheumatic Diseases Volume: 79 Issue: 1 Pages: 77-87
  • DOI: 10.1136/annrheumdis-2019-216561
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hypocomplementemia is related to elevated serum levels of IgG subclasses other than IgG4 in IgG4-related kidney disease. (2020)
  • Author(s): Fujisawa Y, Mizushima I, Yamada K, Yamamoto M, Saeki T, Matsui S, Tsuge S, Hara S, Ito K, Fujii H, Takahashi H, Nomura H, Kawa S, Kawano M.
  • Journal Title: Mod Rheumatol. Volume: 13 Issue: 1 Pages: 1-8
  • DOI: 10.1080/14397595.2019.1709942
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and Pathological Characteristics of IgG4-Related Periaortitis/Periarteritis and Retroperitoneal Fibrosis Diagnosed Based on Experts’ Diagnosis (2019)
  • Author(s): Mizushima Ichiro、Kasashima Satomi、Fujinaga Yasunari、Notohara Kenji、Saeki Takako、Zen Yoh、Inoue Dai、Yamamoto Motohisa、Kasashima Fuminari、Matsumoto Yasushi、Amiya Eisuke、Sato Yasuharu、Yamada Kazunori、Domoto Yukako、Kawa Shigeyuki、Kawano Mitsuhiro、Ishizaka Nobukazu
  • Journal Title: Annals of Vascular Diseases Volume: 12 Issue: 4 Pages: 460-472
  • DOI: 10.3400/avd.oa.19-00085
  • NAID: 130007772896
  • ISSN: 1881-641X, 1881-6428
  • Year and Date: 2019-12-25
  • Peer Reviewed / Open Access
• [Journal Article] IgG4-related periaortitis/periarteritis: An under-recognized condition that is potentially life-threatening (2019)
  • Author(s): Mizushima Ichiro、Kasashima Satomi、Fujinaga Yasunari、Kawano Mitsuhiro、Ishizaka Nobukazu
  • Journal Title: Modern Rheumatology Volume: 29 Issue: 2 Pages: 240-250
  • DOI: 10.1080/14397595.2018.1546367
  • Peer Reviewed / Open Access
• [Journal Article] New insights into the pathophysiology of IgG4-related disease and markers of disease activity. (2019)
  • Author(s): Yamada K, Mizushima I, Kawano M.
  • Journal Title: Expert Review of Clinical Immunology Volume: 15 Issue: 3 Pages: 231-239
  • DOI: 10.1080/1744666x.2019.1560268
  • Peer Reviewed
• [Journal Article] Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts. (2019)
  • Author(s): Wallace ZS, Zhang Y, Perugino CA, Naden R, Choi HK, Stone JH; ACR/EULAR IgG4-RD Classification Criteria Committee.
  • Journal Title: Annals of the Rheumatic Diseases Volume: 78 Issue: 3 Pages: 406-412
  • DOI: 10.1136/annrheumdis-2018-214603
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Abundant a proliferation-inducing ligand (APRIL)-producing macrophages contribute to plasma cell accumulation in immunoglobulin G4-related disease (2018)
  • Author(s): Kawakami Takahiro、Mizushima Ichiro、Yamada Kazunori、Fujii Hiroshi、Ito Kiyoaki、Yasuno Tetsuhiko、Izui Shozo、Yamagishi Masakazu、Huard Bertrand、Kawano Mitsuhiro
  • Journal Title: Nephrology Dialysis Transplantation Volume: 15 Issue: 6 Pages: 960-969
  • DOI: 10.1093/ndt/gfy296
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A case of IgG4-related kidney disease with predominantly unilateral renal atrophy (2018)
  • Author(s): Takeji Akari、Yamada Kazunori、Inoue Dai、Mizushima Ichiro、Hara Satoshi、Ito Kiyoaki、Fujii Hiroshi、Nakajima Kenichi、Mizutomi Kazuaki、Yamagishi Masakazu、Kawano Mitsuhiro
  • Journal Title: CEN Case Reports Volume: 8 Issue: 1 Pages: 8-13
  • DOI: 10.1007/s13730-018-0355-9
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic sensitivity of cutoff values of IgG4-positive plasma cell number and IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with IgG4-related disease. (2018)
  • Author(s): Mizushima I, Yamada K, Harada K, Matsui S, Saeki T, Kondo S, Takahira M, Waseda Y, Hamaguchi Y, Fujii H, Yamagishi M, Kawano M.
  • Journal Title: Modern Rheumatology Volume: 28(2) Issue: 2 Pages: 293-299
  • DOI: 10.1080/14397595.2017.1332540
  • Peer Reviewed
• [Journal Article] New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases. (2017)
  • Author(s): Yamada K, Yamamoto M, Saeki T, Mizushima I, Matsui S, Fujisawa Y, Hara S, Takahashi H, Nomura H, Kawa S, Kawano M.
  • Journal Title: Arthritis Res Ther Volume: 19 Issue: 1 Pages: 262-271
  • DOI: 10.1186/s13075-017-1467-x
  • Peer Reviewed / Open Access
• [Journal Article] A case developing minimal change disease during the course of IgG4-related disease. (2017)
  • Author(s): Yamada K, Zoshima T, Ito K, Mizushima I, Hara S, Horita S, Nuka H, Hamano R, Fujii H, Yamagishi M, Kawano M.
  • Journal Title: Modern Rheumatology Volume: 27(4) Issue: 4 Pages: 712-715
  • DOI: 10.3109/14397595.2015.1019958
  • Peer Reviewed
• [Journal Article] A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease. (2017)
  • Author(s): Horita S, Fujii H, Mizushima I, Fujisawa Y, Hara S, Yamada K, Inoue D, Nakajima K, Harada K, Kawano M.
  • Journal Title: Modern Rheumatology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the (2016)
  • Author(s): Shigeto Horita, Hiroshi Fujii, Ichiro Mizushima, Yuhei Fujisawa, Satoshi Hara, Kazunori Yamada, Dai Inoue, Kenichi Nakajima, Kenichi Harada & Mitsuhiro Kawano
  • Journal Title: Modern Rheumatology Volume: ー Issue: 3 Pages: 542-546
  • DOI: 10.1080/14397595.2016.1245238
  • Peer Reviewed / Open Access
• [Journal Article] Distribution and components of interstitial inflammation and fibrosis in IgG4-related kidney disease: Analysis of autopsy specimens (2016)
  • Author(s): Hara S, Kawano M, Mizushima I, Harada K, Takata T, Saeki T, Ubara Y, Sato Y, Nagata M.
  • Journal Title: Hum Pathol. Volume: 55 Pages: 164-173
  • DOI: 10.1016/j.humpath.2016.05.010
  • NAID: 120007129427
  • Peer Reviewed / Open Access
• [Journal Article] Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study. (2016)
  • Author(s): Mizushima I, Yamamoto M, Inoue D, Nishi S, Taniguchi Y, Ubara Y, Matsui S, Yasuno T, Nakashima H, Takahashi H, Yamada K, Nomura H, Yamagishi M, Saito T, Kawano M.
  • Journal Title: Arthritis Research & Therapy Volume: 18(1) Pages: 273-273
  • NAID: 120006325353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Multicentric Castleman Disease With Tubulointerstitial Nephritis Mimicking IgG4-related Disease: Two Case Reports (2016)
  • Author(s): Zoshima T, Yamada K, Hara S, Mizushima I, Yamagishi M, Harada K, Sato Y, Kawano M.
  • Journal Title: Am J Surg Pathol. Volume: 40(4) Issue: 4 Pages: 495-501
  • DOI: 10.1097/pas.0000000000000575
  • Peer Reviewed / Open Access
• [Journal Article] A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. (2014)
  • Author(s): Hara S, Kawano M, Mizushima I, Yamada K, Fujita K, Harada K, Matsumura M, Yamagishi M, Sato Y, Yamaguchi Y, Nakanuma Y, Nagata M.
  • Journal Title: Mod Rheumatol Volume: 0 Issue: 5 Pages: 0-0
  • DOI: 10.3109/14397595.2014.916836
  • NAID: 120007135033
  • Peer Reviewed / Open Access
• [Presentation] 無治療のIgG4関連疾患患者における疾患増悪に関連する因子の検討 (2019)
  • Author(s): 水島伊知郎, 小西正紘, 眞田創, 鈴木一如, 竹治明梨, 原怜史, 伊藤清亮, 川根隆志, 藤井博, 山田和徳, 川野充弘
  • Organizer: 第63回日本リウマチ学会総会・学術集会
• [Presentation] 腎盂尿管移行部腫瘤を契機として診断された画像異常所見を伴わないIgG4関連腎臓病の一例 (2019)
  • Author(s): 宮永達人, 水島伊知郎, 小西正紘, 眞田創, 鈴木一如, 濱野良子, 北島進, 村本弘昭, 竹治明梨, 原怜史, 伊藤清亮, 川根隆志, 藤井博, 山田和徳, 川野充弘
  • Organizer: 第63回日本リウマチ学会総会・学術集会
• [Presentation] Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to higher systemic disease activity in IgG4-related dacryoadenitis/sialadenitis (2019)
  • Author(s): Masahiro Konishi, Ichiro Mizushima, Hajime Sanada, Kazuyuki Suzuki, Akari Takeji, Satoshi Hara, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano
  • Organizer: EULAR 2019
  • Int'l Joint Research
• [Presentation] 滲出性胸水貯留を認めIgG4関連疾患と黄色爪症候群の症候が混在した胸膜炎の一例 (2019)
  • Author(s): 山野高弘, 川原寛之, 日比野真也, 西岡亮, 蔵島乾, 原怜史, 伊藤清亮, 水島伊知郎, 藤井博, 川野充弘
  • Organizer: 第28回日本シェーグレン症候群学会
• [Presentation] Large vessel vasculitis as a manifestation of IgG4-related disease (2019)
  • Author(s): 水島 伊知郎、 川野 充弘、石坂 信和
  • Organizer: 第83回 日本循環器学会学術集会
  • Invited
• [Presentation] 大規模コホートデータを用いたIgG4関連疾患における低補体血症に関連する因子の検討 (2018)
  • Author(s): 水島伊知郎, 山田和徳, 山本元久, 佐伯敬子, 松井祥子, 谷悠紀子, 原怜史, 伊藤清亮, 藤井博, 川茂幸, 川野充弘
  • Organizer: 第62回日本リウマチ学会総会・学術集会
• [Presentation] 環境要素および併存疾患が血清IgG4及びIgG4関連疾患に与える影響について (2018)
  • Author(s): 藤井博、玉井慎美、吉田美咲、鈴木信博、高橋芳徳、竹治明梨、堀田成人、藤澤雄平、柘植俊介、松永貴弘、蔵島乾、額裕海、原怜史、谷悠紀子、鈴木康倫、伊藤清亮、水島伊知郎、山田和徳、中崎聡、川尻真也、池田啓、中島裕史、川上純、川野充弘
  • Organizer: 第62回日本リウマチ学会総会・学術集会
• [Presentation] IgG4関連尿細管間質性腎炎におけるステロイド治療開始前の腎機能低下速度の検討 (2018)
  • Author(s): 川野充弘、水島伊知郎、谷口義典、佐伯敬子、中島衡、原怜史、松永貴弘、藤井博、山田和徳
  • Organizer: 第62回日本リウマチ学会総会・学術集会
• [Presentation] IgG4関連腎臓病の低補体血症に対するIgG4以外のIgGサブクラスの関与 (2018)
  • Author(s): 水島伊知郎, 山田和徳, 山本元久, 佐伯敬子, 松井祥子, 谷悠紀子, 原怜史, 伊藤清亮, 藤井博, 川茂幸, 川野充弘
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] Serum IgG4 levels at diagnosis can predict the outcomes of untreated patients with IgG4-related disease: a retrospective study (2018)
  • Author(s): Ichiro Mizushima, Nobuhiro Suzuki, Misaki Yoshida, Akari Takeji, Takahiro Matsunaga, Takeshi Zoshima, Satoshi Hara, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano
  • Organizer: EULAR 2018
  • Int'l Joint Research
• [Presentation] Factors Related to Deterioration of IgG4-Related Disease in Untreated Patients with IgG4-Related Disease (2018)
  • Author(s): Ichiro Mizushima, Kazunori Yamada, Satoshi Hara, Kiyoaki Ito, Hiroshi Fujii, Mitsuhiro Kawano
  • Organizer: ACR 2018
  • Int'l Joint Research
• [Presentation] Vessel Involvement in IgG4-Related Disease: A Comparison of Vessel-Limited Cases with Multiple-Organs-Involved Cases (2017)
  • Author(s): Ichiro Mizushima, Mitsuhiro Kawano
  • Organizer: 第81回 日本循環器学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease (2017)
  • Author(s): Ichiro Mizushima, Motohisa Yamamoto, Dai Inoue, Shinichi Nishi, Yoshinori Taniguchi, Yoshifumi Ubara, Shoko Matsui, Tetsuhiko Yasuno, Hitoshi Nakashima, Hiroki Takahashi, Kazunori Yamada, Hideki Nomura, Masakazu Yamagishi, Takao Saito, and Mitsuhiro Kawano
  • Organizer: The 3rd International Symposium on IgG4- Related Disease
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2017-02-15
  • Int'l Joint Research
• [Presentation] Baseline clinical and laboratory features of IgG4-related disease: retrospective multicenter study of 334 cases (2017)
  • Author(s): Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Ichiro Mizushima, Hideki Nomura, Hiroki Takahashi, Mitsuhiro Kawano, Shigeyuki Kawa
  • Organizer: The 3rd International Symposium on IgG4- Related Disease
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2017-02-15
  • Int'l Joint Research
• [Presentation] IgG4関連疾患の既存病変再燃、新規病変出現に関与する因子の差異 (2017)
  • Author(s): 水島 伊知郎、柘植 俊介、藤澤 雄平、原 怜史、鈴木 華恵、伊藤 清亮、會津元彦、藤井 博、山田 和徳、川野 充弘
  • Organizer: 第61回日本リウマチ学会総会・学術集会
• [Presentation] IgG4関連腎症・血管炎・後腹膜線維症 (2017)
  • Author(s): 水島 伊知郎、川野 充弘
  • Organizer: 第61回日本リウマチ学会総会・学術集会
  • Invited
• [Presentation] 低補体血症を合併したIgG4関連腎臓病についての臨床的検討 (2017)
  • Author(s): 藤澤 雄平、水島 伊知郎、柘植 俊介、原 怜史、鈴木 華恵、伊藤 清亮、會津元彦、藤井 博、山田 和徳、川野 充弘
  • Organizer: 第61回日本リウマチ学会総会・学術集会
• [Presentation] 自己免疫性膵炎の維持療法中に片腎優位の萎縮を来したIgG4関連腎臓病の1例 (2017)
  • Author(s): 和田 明梨、山田 和徳、水島 伊知郎、原 怜史、伊藤 清亮、藤井 博、水冨 一秋、川野 充弘
  • Organizer: 第61回日本リウマチ学会総会・学術集会
• [Presentation] IgG4関連腎臓病と低補体血症についての臨床的検討 (2017)
  • Author(s): 藤澤 雄平、水島 伊知郎、柘植 俊介、原 怜史、鈴木 華恵、伊藤 清亮、藤井 博、山田 和徳、川野 充弘
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] Different factors are related to recurrence of existing organ involvement and new development of organ involvement in IgG4-related disease (2017)
  • Author(s): Ichiro Mizushima, Syunsuke Tsuge, Yuhei Fujisawa, Satoshi Hara, Fae Suzuki, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano
  • Organizer: EULAR 2017
  • Int'l Joint Research
• [Presentation] Hypocomplementemia is related to elevated serum levels of IgG subclasses other than IgG4 in IgG4-related kidney disease (2017)
  • Author(s): Yuhei Fujisawa, Ichiro Mizushima, Syunsuke Tsuge, Satoshi Hara, Fae Suzuki, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano
  • Organizer: EULAR 2017
  • Int'l Joint Research
• [Presentation] Diagnostic sensitivity of cutoff values of IgG4-positive plasma cell number and IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with IgG4-related disease (2017)
  • Author(s): Shunsuke Tsuge, Ichiro Mizushima, Yuhei Fujisawa, Satoshi Hara, Fae Suzuki, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano
  • Organizer: EULAR 2017
  • Int'l Joint Research
• [Presentation] リウマチ性多発筋痛様の症状を伴ったIgG4関連疾患の1例 (2017)
  • Author(s): 吉田 美咲、伊藤 清亮、鈴木 信博、松永 貴弘、蔵島 乾、原 怜史、水島 伊知郎、藤井 博、山田 和徳、川野 充弘
  • Organizer: 第29回中部リウマチ学会
• [Presentation] IgG4陽性形質細胞浸潤を伴う尿細管間質性腎炎を認めた多中心性キャッスルマン病の4例 (2017)
  • Author(s): 鈴木 康倫、蔵島 乾、原 怜史、水島 伊知郎、藤井 博、山田 和徳、川野 充弘
  • Organizer: 第26回日本シェーグレン症候群学会
• [Presentation] 尿細管間質性腎炎を伴うシェーグレン症候群とIgG4関連腎臓病におけるM2マクロファージの臨床病理学的検討 (2017)
  • Author(s): 鈴木 康倫、蔵島 乾、原 怜史、水島 伊知郎、藤井 博、山田 和徳、川野 充弘
  • Organizer: 第26回日本シェーグレン症候群学会
• [Presentation] Hypocomplementemia is Closely Related to IgG Subclasses Other than IgG4 in IgG4-Related Disease. (2017)
  • Author(s): Ichiro Mizushima, Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Shoko Matsui, Satoshi Hara, Hiroki Takahashi, Hideki Nomura, Shigeyuki Kawa, Mitsuhiro Kawano
  • Organizer: ACR 2017
  • Int'l Joint Research
• [Presentation] Multicenter study on the rate of renal function deterioration in IgG4-related tubulointerstitial nephritis. (2017)
  • Author(s): Mitsuhiro Kawano, Ichiro Mizushima, Yoshinori Taniguchi, Takako Saeki, Hitoshi Nakashima, Satoshi Hara, Hiroshi Fujii, Kazunori Yamada
  • Organizer: ACR 2017
  • Int'l Joint Research
• [Presentation] A Case of IgG4-Related Kidney Disease with Predominantly Unilateral Renal Atrophy (2016)
  • Author(s): Akari Wada, Kazunori Yamada, Ichiro Mizushima, Satoshi Hara, Kiyoaki Ito, Hiroshi Fujii, Kazuaki Mizutomi, Mitsuhiro Kawano
  • Organizer: ASN 2016
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] Clinical and Laboratory Features of IgG4-Related Retroperitoneal Fibrosis/Periarteritis in Japan: Retrospective Multicenter Study of 99 Cases (2016)
  • Author(s): Ichiro Mizushima, Satomi Kasashima, Motohisa Yamamoto, Takako Saeki, Kazunori Yamada, Dai Inoue, Fuminori Kasashima, Yasushi Matsumoto, Eisuke Amiya, Kenji Notohara, Yasuharu Sato, Yoh Zen, Shigeyuki Kawa, Mitsuhiro Kawano, Nobukazu Ishizaka
  • Organizer: ACR 2016
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] Analysis of 84 patients with IgG4-related disease and malignancy (2016)
  • Author(s): Kazunori Yamada, Ichiro Mizushima, Hideki Nomura, Mitsuhiro Kawano
  • Organizer: ACR 2016
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] IgG4関連心血管病変の臨床像と診断基準，内科的治療 (2016)
  • Author(s): 水島伊知郎、川野充弘
  • Organizer: 第57回日本脈管学会総会
  • Place of Presentation: 奈良
  • Year and Date: 2016-10-13
  • Invited
• [Presentation] IgG4関連動脈周囲炎/後腹膜線維症の臨床像に関する多施設共同研究：99例の解析 (2016)
  • Author(s): 水島伊知郎、笠島里美、山本元久、佐伯敬子、山田和徳、井上大、笠島史成、松本康、網谷英介、能登原憲司、佐藤康晴、全陽、川茂幸、川野充弘、石坂信和
  • Organizer: 第25回日本シェーグレン症候群学会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-08
• [Presentation] IgG4関連腎臓病における低補体血症についての臨床的検討 (2016)
  • Author(s): 藤澤雄平、水島伊知郎、柘植俊介、原怜史、鈴木華恵、伊藤清亮、藤井博、山田和徳、川野充弘
  • Organizer: 第25回日本シェーグレン症候群学会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-08
• [Presentation] IgG4関連腎臓病においてステロイド治療前の腎機能障害が治療後腎萎縮出現に与える影響 (2016)
  • Author(s): 水島伊知郎、山本元久、山田和徳、谷口義典、乳原善文、松井祥子、中島衡、西慎一、川野充弘
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
• [Presentation] IgG4関連腎臓病におけるステロイド治療後の腎萎縮出現に関与する因子の検討 (2016)
  • Author(s): 水島伊知郎、山本元久、山田和徳、谷口義典、乳原善文、松井祥子、中島衡、西慎一、川野充弘
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-04-21
• [Presentation] 石川県の一般人口における血清IgG4値と疾患の関連についての検討 (2016)
  • Author(s): 藤井博、額裕海、和田明梨、高橋芳徳、堀田成人、藤澤雄平、柘植俊介、蔵島乾、原怜史、鈴木康倫、伊藤清亮、會津元彦、濱野良子、水島伊知郎、山田和徳、中崎聡、川上純、玉井慎美、中島裕史、池田啓
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-04-21
• [Presentation] IgG4関連疾患85例における悪性腫瘍合併例の臨床的解析 (2016)
  • Author(s): 山田和徳、水島伊知郎、川野充弘
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-04-21