| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
CD300a is identified as a phosphatidylserine receptor and involved in the regulation of apoptosis. In this study, we revealed that CD300a expression on CD8+ T cells was upregulated after activation of the cells, and that CD300a+CD8+ T cells had increased effector functions such as cytokine production and cytotoxic activity. The effector functions were suppressed by the interaction with CD300a and apoptotic cells. CD300a+CD8+ T cells were increased in patients with systemic sclerosis (SSc) compared with healthy controls and were appreciably associated with the severity of skin sclerosis. These findings indicate that upregulated CD300a expression on CD8+ T cells reflects disease severity and is involved in SSc pathogenesis.
|
