Role of mast cells in adipose-derived chronic inflammation

• Project/Area Number: 16K19607
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Fujioka Kazuki 京都府立医科大学, 医学部附属病院, 研究員 (30762174)
• Research Collaborator: Mazda Osam 京都府立医科大学, 医学研究科, 教授 (00271164) ; KISHIDA Tsunao 京都府立医科大学, 医学研究科, 准教授 (00370205) ; KAWAHITO Yutaka 京都府立医科大学, 医学研究科, 准教授 (50336731) ; KOHNO Masataka 京都府立医科大学, 医学研究科, 講師 (60405256)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: マスト細胞 / 脂肪組織 / 炎症 / マクロファージ / 脂肪細胞 / 慢性炎症 / 免疫学 / アレルギー

Outline of Final Research Achievements

It is well known that adipose tissues relating factors are involved in the pathogenesis of many diseases in terms of chronic inflammation. Among these diseases, macrophages in adipose tissue play a significant role, while the involvement of mast cells has become known recently. However, precise molecular mechanisms between mast cells and adipose tissue relating inflammation are remained to be fully understood. We examined influence of adipose tissue on mast cells, and clarify the phenotypic conversion of mast cells to macrophage-like cells which have the effector function in adipose tissue relating inflammation. This findings lead to the elucidation of a new mechanism of fat and mast cell interaction, and it is expected to have a great impact on understanding and control of adipose-derived chronic inflammation.

Research Products

• [Journal Article] Roles of high-mobility group box 1 and thrombin in murine pulmonary fibrosis and the therapeutic potential of thrombomodulin (2018)
  • Author(s): Kida T, et al.
  • Journal Title: American Journal of Physiology-Lung Cellular and Molecular Physiology Volume: 314 Issue: 3 Pages: L473-L483
  • DOI: 10.1152/ajplung.00287.2017
  • Peer Reviewed
• [Journal Article] Role of allograft inflammatory factor-1 in bleomycin-induced lung fibrosis (2018)
  • Author(s): Hidetake Nagahara, Takahiro Seno, Aihiro Yamamoto, Hiroshi Obayashi, Takuya Inoue, Takashi Kida, Amane Nakabayashi, Yuji Kukida, Kazuki Fujioka, Wataru Fujii, Ken Murakami, Masataka Kohno, Yutaka Kawahito.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 495(2) Issue: 2 Pages: 1901-1907
  • DOI: 10.1016/j.bbrc.2017.12.035
  • Peer Reviewed / Open Access / Int'l Joint Research