The function of monocyte subsets distinguished by the expression of CD14 and CD16 in rheumatoid arthritis

• Project/Area Number: 16K19610
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: 独立行政法人国立病院機構(東京医療センター臨床研究センター) (2017-2018); Tokyo Dental College (2016)
• Principal Investigator: Tsukamoto Masako 独立行政法人国立病院機構(東京医療センター臨床研究センター), 政策医療企画研究部, 医師 (80570910)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 関節リウマチ / 単球 / Fcγ受容体 / 末梢血単球 / 免疫学

Outline of Final Research Achievements

The goal for treatment of rheumatoid arthritis is remission after using biological agents. However, there are still many cases that thier response for treatment is poor and joint destruction progresses. We focused on new target but previous target such as cytokines. The purpose of this study was to clarify the mechanism of monocyte subsets in the pathogenesis of rheumatoid arthritis.

Academic Significance and Societal Importance of the Research Achievements

関節リウマチに対する治療は、生物学的製剤の登場により寛解が目標となったが、未だに関節破壊が進行している症例が多い。従来とは違った新規の治療標的を見つけるため、新たに発見された単球に注目し、関節リウマチにおける働きについて研究を行った。

Research Products

• [Journal Article] Increased circulating CD14brightCD16+ intermediate monocytes are regulated by TNF-α and IL-6 axis in accordance with disease activity in patients with rheumatoid arthritis (2018)
  • Author(s): Masako Tsukamoto, Katsuya Suzuki, Noriyuki Seta, Tsutomu Takeuchi
  • Journal Title: Clinical and Experimental Rheumatology Volume: 36 Pages: 540-544
  • Peer Reviewed
• [Journal Article] CD14brightCD16+ intermedicate monocytes are induced by interleukin-10 and positively correlated with disease activity in rheumatoid arthritis. (2017)
  • Author(s): Tsukamoto M, Seta N, Yoshimoto K, Suzuki K, Yamaoka K, Takeuchi T
  • Journal Title: Arthritis Res Ther Volume: 19 Issue: 1 Pages: 28-28
  • DOI: 10.1186/s13075-016-1216-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Increased circulating CD14brightCD16+ intermediate monocytes are regulated by interleukin-10 in patients with rheumatoid arthritis (2016)
  • Author(s): Masako Tsukamoto, Noriyuki Seta, Keiko Yoshimoto, Katsuya Suzuki, Kunihiro Yamaoka, Tsutomu Takeuchi
  • Organizer: 第82回米国リウマチ学会議
  • Place of Presentation: ワシントンD.C.
  • Year and Date: 2016-11-11
  • Int'l Joint Research