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Ecology of human polyomaviruses residing in the skin: Exploration of its relationship with cutaneous diseases

Research Project

Project/Area Number 16K19612
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionKochi University

Principal Investigator

Hashida Yumiko  高知大学, 教育研究部医療学系基礎医学部門, 助教 (00767999)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsウイルス / 皮膚常在 / 微生物 / 疫学 / 皮膚 / 微生物叢
Outline of Final Research Achievements

The human skin, which functions as the barrier between the body and outside environment, is inhabited by diverse microorganisms. In this study, we focused on the skin virome and explored the relationship between infection status of viruses residing in the skin and cutaneous diseases. This study provides the first data on age-specific prevalence and infection levels of some human polyomaviruses, including Merkel cell polyomavirus, human polyomavirus 6 and human polyomavirus 7, in the skin of healthy individuals as well as the skins of patients with skin cancers and patients with inflammatory skin diseases.

Academic Significance and Societal Importance of the Research Achievements

常在微生物に関する研究は、腸内細菌然り細菌叢に注目されることが多く、ウイルス叢に関する知見は不足している。本研究では、皮膚常在ウイルスに注目することにより、不足して皮膚常在ウイルスに関する情報蓄積への貢献ができた。また、健常者の各年代における皮膚常在ウイルスの感染量・ゲノム情報などを得ることができた。このように、今後の皮膚常在ウイルス叢研究の基盤となるデータを得ることができたことは、社会的意義が大きいと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Genetic Variability of the Noncoding Control Region of Cutaneous Merkel Cell Polyomavirus: Identification of Geographically-Related Genotypes.2018

    • Author(s)
      Yumiko Hashida, Tomonori Higuchi, Kiyohiko Matsui, Yuka Shibata, Kimiko Nakajima, Shigetoshi Sano, Masanori Daibata.
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 217 Issue: 10 Pages: 1601-1611

    • DOI

      10.1093/infdis/jiy070

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Merkel cell polyomavirus and Langerhans cell neoplasm.2018

    • Author(s)
      Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F.
    • Journal Title

      Cell Commun Signal.

      Volume: 16(1) Issue: 1 Pages: 49-49

    • DOI

      10.1186/s12964-018-0261-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation and characteristics of a novel "double-hit" high grade B-cell lymphoma cell line DH-My6 with MYC/IGH and BCL6/IGH gene arrangements and potential molecular targeted therapies.2018

    • Author(s)
      Hiroaki Kikuchi, Tomonori Higuchi, Yumiko Hashida, Ayuko Taniguchi, Mikio Kamioka, Takahiro Taguchi, Akihito Yokoyama, Ichiro Murakami, Mikiya Fujieda, Masanori Daibata.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 71 Pages: 33482-33499

    • DOI

      10.18632/oncotarget.26060

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence and Genetic Variability of Human Polyomaviruses 6 and 7 in Healthy Skin Among Asymptomatic Individuals2018

    • Author(s)
      Hashida Yumiko、Higuchi Tomonori、Matsuzaki Shigenobu、Nakajima Kimiko、Sano Shigetoshi、Daibata Masanori
    • Journal Title

      Journal of Infectious Diseases

      Volume: 217 Issue: 3 Pages: 483-493

    • DOI

      10.1093/infdis/jix516

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential gene expression profiling linked to tumor progression of splenic marginal zone lymphoma2017

    • Author(s)
      Higuchi Tomonori、Hashida Yumiko、Taniguchi Ayuko、Kamioka Mikio、Daibata Masanori
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 11026-11026

    • DOI

      10.1038/s41598-017-11389-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ecology of Merkel Cell Polyomavirus in Healthy Skin Among Individuals in an Asian Cohort2016

    • Author(s)
      Hashida Y, Kamioka M, Tanaka M, Hosokawa S, Murakami M, Nakajima K, Kikuchi H, Fujieda M, Sano S, Daibata M
    • Journal Title

      J Infect Dis

      Volume: 213(11) Issue: 11 Pages: 1708-1716

    • DOI

      10.1093/infdis/jiw040

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High load of Merkel cell polyomavirus DNA detected in the normal skin of Japanese patients with Merkel cell carcinoma.2016

    • Author(s)
      Yumiko Hashida, Kimiko Nakajima, Hideki Nakajima, Takeo Shiga, Moe Tanaka, Masanao Murakami, Shigenobu Matsuzaki, Seiji Naganuma, Naoki Kuroda, Yasutaka Seki, Harutaka Katano, Shigetoshi Sano, Masanori Daibata.
    • Journal Title

      Journal of Clinical Virology

      Volume: 82 Pages: 101-107

    • DOI

      10.1016/j.jcv.2016.07.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Genetic variability of the noncoding control region of cutaneous Merkel cell polyomavirus2018

    • Author(s)
      Yumiko Hashida, Tomonori Higuchi, Kiyohiko Matsui, Masanori Daibata
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Quantification of MCPyV DNA loads in the tumor tissues and nonlesional skins of patients with Merkel cell carcinoma2018

    • Author(s)
      Yumiko Hashida, Tomonori Higuchi, Shigenobu Matsuzaki, Masanori Daibata
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Antiproliferative effects of MYV/PLK1 inhibitions in a cell line derived from lymphoma with MYC/BCL6 rearrangements2018

    • Author(s)
      Tomonori Higuchi, Hiroaki Kikuchi, Yumiko Hashida, Ayuko Taniguchi, Mikio Kamioka, Takahiro Taguchi, Ichiro Murakami, Masanori Daibata
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] バクテリオファージKHP30の感染能に及ぼすピロリ菌保有制限ー修飾系の解析2017

    • Author(s)
      松澤 佑一、内山淳平、竹内啓晃、氏原隆子、橋田裕美子、樋口智紀、田中望紅、冨永宗一竜、大畑雅典、松崎茂展
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター展示棟(宮城県・仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] The relationship between loads of Merkel cell polyomavirus and carcinogenesis.2017

    • Author(s)
      Yumiko Hashida, Tomonori Higuchi, Shigenobu Matsuzaki, Masanori Daibata
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] PLK1upregulation promotes cell proliferation and suurvival in transformed-aggressive splenic marginal zone lymphoma2017

    • Author(s)
      Tomonori Higuchi, Yumiko Hashida, Mikio Kamioka, Ayuko Taniguchi, Masanori Daibata
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] High load of MCPyV in the nonlesional skin of patients with Merkel cell carcinoma and among a cohort of asymptomatic elderly individuals2017

    • Author(s)
      Yumiko Hashida, Tomonori Higuchi, Shigenobu Matsuzaki, Kimiko Nakajima, Shigetoshi Sano, Masanori Daibata
    • Organizer
      日本研究皮膚科学会第42回年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Epidemiological study of Merkel cell polyomavirus in healthy skin among healthy individuals in Japan.2016

    • Author(s)
      Yumiko Hashida, Moe Tanaka, Masanao Murakami, Shigenobu Matsuzaki, Masanori Daibata
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Phylogenetic analysis of Merkel cell polyomavirus based on full-length LT and VP1 sequences derived from normal skin of healthy individuals.2016

    • Author(s)
      Moe Tanaka, Yumiko Hashida, Masanao Murakami, Shigenobu Matsuzaki, Masanori Daibata
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Ecology of Merkel Cell Polyomavirus in Healthy Skin Shows a Close Agreement with Interleukin-1 Loop Model in Langerhans Cell Histiocytosis.2016

    • Author(s)
      Ichiro Murakami, Junko Nakashima, Yumiko Hashida, Masanori Daibata, Michiko Matsushita,Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Kazuhiko Hayashi, Takashi Oka, Tadashi Yoshino, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert
    • Organizer
      32nd Annual Meeting of the Histiocyte Society
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2016-10-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] High burden of Merkel cell polyomavirus DNA in the nonlesional, sun-exposed skin of patients with Merkel cell carcinoma.2016

    • Author(s)
      Kimiko Nakajima, Yumiko Hashida, Yuka Shibata, Takeo Shiga, Hideki Nakajima, Masanori Daibata, Shigetoshi Sano
    • Organizer
      46th Annual ESDR Meeting 2016
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] High burden of Merkel cell polyomavirus DNA in the sun-exposed skin of elder adults.2016

    • Author(s)
      Kimiko Nakajima, Yumiko Hashida, Yuka Shibata, Takeo Shiga, Hideki Nakajima, Masanori Daibata, Shigetoshi Sano
    • Organizer
      ASIA-PACIFIC COMBINED DERMATOLOGY RESEARCH CONFERENCE
    • Place of Presentation
      Noosa, Queensland, Australia
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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