Ecology of human polyomaviruses residing in the skin: Exploration of its relationship with cutaneous diseases
| Project/Area Number |
16K19612
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
Hashida Yumiko 高知大学, 教育研究部医療学系基礎医学部門, 助教 (00767999)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | ウイルス / 皮膚常在 / 微生物 / 疫学 / 皮膚 / 微生物叢 |
|---|
| Outline of Final Research Achievements |
The human skin, which functions as the barrier between the body and outside environment, is inhabited by diverse microorganisms. In this study, we focused on the skin virome and explored the relationship between infection status of viruses residing in the skin and cutaneous diseases. This study provides the first data on age-specific prevalence and infection levels of some human polyomaviruses, including Merkel cell polyomavirus, human polyomavirus 6 and human polyomavirus 7, in the skin of healthy individuals as well as the skins of patients with skin cancers and patients with inflammatory skin diseases.
|
| Academic Significance and Societal Importance of the Research Achievements |
常在微生物に関する研究は、腸内細菌然り細菌叢に注目されることが多く、ウイルス叢に関する知見は不足している。本研究では、皮膚常在ウイルスに注目することにより、不足して皮膚常在ウイルスに関する情報蓄積への貢献ができた。また、健常者の各年代における皮膚常在ウイルスの感染量・ゲノム情報などを得ることができた。このように、今後の皮膚常在ウイルス叢研究の基盤となるデータを得ることができたことは、社会的意義が大きいと考えられる。
|
Report
(4 results)
Research Products
(19 results)
-
-
[Journal Article] Merkel cell polyomavirus and Langerhans cell neoplasm.2018
Author(s)
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F.
-
Journal Title
Cell Commun Signal.
Volume: 16(1)
Issue: 1
Pages: 49-49
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
[Journal Article] High load of Merkel cell polyomavirus DNA detected in the normal skin of Japanese patients with Merkel cell carcinoma.2016
Author(s)
Yumiko Hashida, Kimiko Nakajima, Hideki Nakajima, Takeo Shiga, Moe Tanaka, Masanao Murakami, Shigenobu Matsuzaki, Seiji Naganuma, Naoki Kuroda, Yasutaka Seki, Harutaka Katano, Shigetoshi Sano, Masanori Daibata.
-
Journal Title
Journal of Clinical Virology
Volume: 82
Pages: 101-107
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
[Presentation] Ecology of Merkel Cell Polyomavirus in Healthy Skin Shows a Close Agreement with Interleukin-1 Loop Model in Langerhans Cell Histiocytosis.2016
Author(s)
Ichiro Murakami, Junko Nakashima, Yumiko Hashida, Masanori Daibata, Michiko Matsushita,Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Kazuhiko Hayashi, Takashi Oka, Tadashi Yoshino, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert
Organizer
32nd Annual Meeting of the Histiocyte Society
Place of Presentation
Dublin, Ireland
Year and Date
2016-10-17
Related Report
Int'l Joint Research
-
-
