| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To clarify and identify of HIV-1-specific CD4+ T cells that contributed to suppression of HIV-1 replication, we analyzed the specific CD4+ T cell responses using Gag, Pol, Nef overlapping 17-mer peptides and its pools in 394 chronically HIV-1 clade B-infected Japanese individuals. We found that the T cell responders to the 3 peptide pools, Gag3, Gag4, and Pol18, had lower plasma viral load that the non-responders, and total magnitude of their responses were significantly correlated with lower plasma viral load. However, we could not establish Gag3, Gag4, and Pol18-specific CD4+ T cells form the responders. In contrast of them, we finally succeeded to establish the CD4+ T cell clones specific for a single 17mer peptide, Gag17-45, in Gag6 peptide pool from a Gag6-responder who showed high T cell response. These results gave the important knowledge and information for the development of HIV-1 vaccine.
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