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The B cell independent mechanism of Rituximab in Pediatric-Onset Intractable Nephrotic Syndrome.

Research Project

Project/Area Number 16K19623
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionHirosaki University

Principal Investigator

Watanabe Shojiro  弘前大学, 医学部附属病院, 助教 (80597196)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywordsネフローゼ症候群 / SMPDL3b / リツキシマブ / 難治性ネフローゼ症候群 / 蛍光抗体法 / 細胞、組織
Outline of Final Research Achievements

To examine the role of SMPDL3b in the pathogenesis of NS, we examined urinary excretion of SMPDL3b by using dot blotting. Urinary excretion of SMPDL3b in patients with heavy proteinuric NS was significantly decreased compared to that in patients in remission, those with IgA nephropathy/vasculitis, and controls.
These findings suggest that changes in SMPDL3b expression on the podocyte probably occur in pediatric-onset NS. Among them, RTX may work on podocyte in SMPDL3b-dependent manner, suggesting that low expressions of SMPDL3b in urine and glomerular immunoreactivity even in remission resulted in the RTX-resistance. Although detailed mechanism of downregulation of SMPDL3b expression remains to be elucidated, SMPDL3b is, at least in part, involved in the pathogenesis of pediatric-onset NS. In addition, measurement of urinary excretion of SMPDL3b could be a possible in invasive biomarker to predict reactivity to rituximab therapy in pediatric onset nephrotic syndrome.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Urinary excretion of SMPDL-3b in children with intractable nephrotic syndrome.2017

    • Author(s)
      Watanabe S, Tsugawa K, Tsuruga K, Imaizumi T, Tanaka H
    • Journal Title

      Pediatrics International

      Volume: 59 Issue: 10 Pages: 1112-1115

    • DOI

      10.1111/ped.13355

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] URINARY EXCRETION AND GLOMERULAR EXPRESSION OF SPHINGOMYELINASE PHOSPHODIESTERASE ACID-LIKE 3B IN PEDIATRIC-ONSET NEPHROTIC SYNDROME2018

    • Author(s)
      Shojiro Watanabe, Tomomi Aizawa, Koji Tsugawa, Kazushi Tsuruga, Etsuro Ito, Hiroshi Tanaka
    • Organizer
      the 55th ERA-EDTA Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小児難治性ネフローゼ症候群における尿中SMPDL3b発現の検討2018

    • Author(s)
      渡辺 祥二郎、相澤 知美、津川 浩二、敦賀 和志、田中 完
    • Organizer
      第61回日本腎臓学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 特発性ネフローゼ症候群における糸球体上皮細胞のSphingomyelin-phosphodiesterase acid-like 3b (SMPDL-3b)2018

    • Author(s)
      渡邊 祥二郎、田中 完
    • Organizer
      第53回小児腎臓病学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 小児難治性ネフローゼ症候群でのSphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3b)の発現に関する検討2017

    • Author(s)
      渡邊 祥二郎、津川 浩二、敦賀 和志、田中 完
    • Organizer
      第60回日本腎臓学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Urinary and glomerular expressions of SMPDL3b in pediatric onset intractable nephrotic syndrome2017

    • Author(s)
      Shojiro Watanabe, Kouji Tsugawa, Kazushi Tsuruga, Hiroshi Tanaka
    • Organizer
      第52回小児腎臓病学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Urinary and glomerular expressions of SMPDL3b in pediatric-onset intractable nephrotic syndrome2017

    • Author(s)
      Shojiro Watanabe, Tomomi Aizawa, Koji Tsugawa, Kazushi Tsuruga, Hiroshi Tanaka
    • Organizer
      13th Asian Congress of Pediatric Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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