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Establishment of detection methods of myocardial ischemia in patients with Kawasaki disease using novel parameters of electrocardiography and magnetocardiography

Research Project

Project/Area Number 16K19627
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionNational Cardiovascular Center Research Institute (2018)
University of Tsukuba (2016-2017)

Principal Investigator

Kato Yoshiaki  国立研究開発法人国立循環器病研究センター, 病院, 医師 (90635608)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心磁図 / 川崎病 / 電流分布 / 心筋虚血 / 冠動脈病変 / 再分極異常 / 生体磁気 / 電流ベクトル
Outline of Final Research Achievements

We analyzed parameters of magnetocardiography (MCG) in 63 patients who had Kawasaki disease-induced coronary artery lesions confirmed by angiography. We calculated the repolarization abnormal score from MCG parameters based on current distributions of T wave. We divided subjects into two groups according to the presence of coronary stenotic lesions, and compared the scores. There was a significant difference in the repolarization abnormal score between two groups (p = 0.019). Score was higher in the group of coronary stenotic lesions (2.5 ± 1.68). The sensitivity of the score over “1” for coronary stenotic lesion was 88.9 %, and specificity and positive predictive value were 29.6 % and 62.7 % respectively. In this study, due to the low specificity, there was limitation in detection of coronary stenotic lesions using repolarization abnormal score alone. However, if combined with other modalities, MCG-based assessments might be useful in detection of myocardial ischemia.

Academic Significance and Societal Importance of the Research Achievements

川崎病の一部では冠動脈病変を来し、心筋虚血が問題となる。簡易かつ非侵襲的に心筋虚血を検出できる方法として心磁図の有用性を検討した。川崎病冠動脈病変の患者における再分極過程の異常を心磁図による電流分布から定量的な評価を行い、その特徴を検討した。心磁図を用いて早期に心筋虚血を検出し、治療介入を開始できれば、心血管イベントのリスクを軽減でき、川崎病患者の予後改善に貢献できる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (26 results)

All 2019 2018 2017 2016

All Journal Article (13 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 3 results) Book (2 results)

  • [Journal Article] Low‐dose i.v. urokinase for coronary thrombosis in Kawasaki disease2019

    • Author(s)
      Serizawa Haruna、Lin Lisheng、Sato Takuro、Takahashi‐Igari Miho、Kato Yoshiaki
    • Journal Title

      Pediatrics International

      Volume: 61 Issue: 3 Pages: 302-303

    • DOI

      10.1111/ped.13783

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of immunity against Epstein‐Barr virus infection in a patient with CHARGE/complete DiGeorge syndrome after peripheral blood lymphocyte transfusion2019

    • Author(s)
      Hosaka Sho、Kobayashi Chie、Saito Hirota、Imai-Saito Ayako、Suzuki Ryoko、Iwabuchi Atsushi、Kato Yoshiaki、Jimbo Takahiro、Watanabe Nobuyuki、Onodera Masafumi、Imadome Ken‐Ichi、Masumoto Kouji、Nanmoku Toru、Fukushima Takashi、Kosaki Kenjiro、Sumazaki Ryo、Takada Hidetoshi
    • Journal Title

      Pediatric Transplantation

      Volume: - Issue: 4

    • DOI

      10.1111/petr.13424

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial Dysfunction of Conduit Arteries in Patients with Repaired Coarctation of the Aorta2018

    • Author(s)
      Nozaki Y, Nakayama-Inaba K, Ishizu T, Iida N, Kato Y, Hiramatsu Y, Horigome H
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 6 Pages: 1340-1345

    • DOI

      10.1536/ihj.17-564

    • NAID

      130007521714

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2018-11-30
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) ― Digest Version ―2018

    • Author(s)
      umitomo N, Baba R, Doi S, Higaki T, Horie M, Nagashima M, Niwa K, Ogawa S, Okumura K, Tsutsui H (et al. )
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 9 Pages: 2385-2444

    • DOI

      10.1253/circj.CJ-66-0153

    • NAID

      130007438850

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-08-24
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Echocardiography in WPW Syndrome2018

    • Author(s)
      Kato Yoshiaki
    • Journal Title

      Pediatric Cardiology and Cardiac Surgery

      Volume: 34 Issue: 2 Pages: 75-76

    • DOI

      10.9794/jspccs.34.75

    • NAID

      130007384654

    • ISSN
      0911-1794, 2187-2988
    • Year and Date
      2018-03-01
    • Related Report
      2018 Annual Research Report
  • [Journal Article] Ultrasonographic diagnosis of diaphragm paralysis in a neonate during mechanical ventilation after cardiac surgery2018

    • Author(s)
      Nozaki Yoshihiro、Lin Lisheng、Kato Yoshiaki
    • Journal Title

      Cardiology in the Young

      Volume: 28 Issue: 5 Pages: 776-778

    • DOI

      10.1017/s1047951118000197

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 新生児医療 最新トピックNEXT 胎児心磁図2018

    • Author(s)
      加藤愛章、堀米仁志
    • Journal Title

      NEONATAL CARE(ネオネイタルケア)

      Volume: 2 Pages: 56-56

    • Related Report
      2017 Research-status Report
  • [Journal Article] Arrhythmia in Adults with Congenital Heart Disease2017

    • Author(s)
      Kato Yoshiaki
    • Journal Title

      Pediatric Cardiology and Cardiac Surgery

      Volume: 33 Issue: 5 Pages: 385-394

    • DOI

      10.9794/jspccs.33.385

    • NAID

      130006195234

    • ISSN
      0911-1794, 2187-2988
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interpretation of Results of Genetic Tests in Long QT Syndrome2017

    • Author(s)
      Kato Yoshiaki
    • Journal Title

      Pediatric Cardiology and Cardiac Surgery

      Volume: 33 Issue: 6 Pages: 441-443

    • DOI

      10.9794/jspccs.33.441

    • NAID

      130006307364

    • ISSN
      0911-1794, 2187-2988
    • Related Report
      2017 Research-status Report
  • [Journal Article] Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant2017

    • Author(s)
      Lin Lisheng、Takahashi-Igari Miho、Kato Yoshiaki、Nozaki Yoshihiro、Obata Mana、Hamada Hiromi、Horigome Hitoshi
    • Journal Title

      Case Reports in Pediatrics

      Volume: 2017 Pages: 1-3

    • DOI

      10.1155/2017/6570465

    • NAID

      120007128988

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Catheter Ablation Targeting the Trigger Beats in Inherited Catecholaminergic Polymorphic Ventricular Tachycardia2017

    • Author(s)
      Kaneshiro Takashi、Nogami Akihiko、Kato Yoshiaki、Kuroki Kenji、Komatsu Yuki、Tada Hiroshi、Sekiguchi Yukio、Horigome Hitoshi、Aonuma Kazutaka
    • Journal Title

      JACC: Clinical Electrophysiology

      Volume: 3 Issue: 9 Pages: 1062-1063

    • DOI

      10.1016/j.jacep.2017.04.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Routine clinical heart examinations using SQUID magnetocardiography at University of Tsukuba Hospital2017

    • Author(s)
      Inaba T、Nakazawa Y、Yoshida K、Kato Y、Hattori A、Kimura T、Hoshi T、Ishizu T、Seo Y、Sato A、Sekiguchi Y、Nogami A、Watanabe S、Horigome H、Kawakami Y、Aonuma K
    • Journal Title

      Superconductor Science and Technology

      Volume: 30 Issue: 11 Pages: 114003-114003

    • DOI

      10.1088/1361-6668/aa8c26

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 胎児心磁図2016

    • Author(s)
      加藤愛章
    • Journal Title

      Japanese Journal of Electrocardiology

      Volume: 36 Issue: 3 Pages: 212-215

    • DOI

      10.5105/jse.36.212

    • NAID

      130005519688

    • ISSN
      0285-1660, 1884-2437
    • Related Report
      2016 Research-status Report
  • [Presentation] 先天性心疾患症例 と 不整脈 -術前、周術期から術後まで- 術前の診断と評価2018

    • Author(s)
      加藤愛章
    • Organizer
      第54回日本小児循環器学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心磁図の臨床応用 -胎児から成人まで-2018

    • Author(s)
      加藤愛章
    • Organizer
      第22回西日本小児循環器研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎児心磁図の臨床応用2018

    • Author(s)
      加藤愛章
    • Organizer
      第69回大阪小児循環器談話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 皮下植込み型リードシステムを用いた複雑心奇形の小児に対するICD植込み2017

    • Author(s)
      加藤愛章、松原宗明、林立申、野崎良寛、石川伸行、高橋実穂、塩野淳子、平松祐司、堀米仁志
    • Organizer
      第9回植込みデバイス関連冬季大会
    • Place of Presentation
      グランフロント大阪、大阪府、大阪市
    • Year and Date
      2017-02-17
    • Related Report
      2016 Research-status Report
  • [Presentation] RHYTHMIAマッピングシステムで最早期興奮部位の特定に苦慮した左心耳起源心房頻拍の8歳男児例2017

    • Author(s)
      加藤愛章、山崎浩、野崎良寛、石川伸行、高橋実穂、村上卓、堀米仁志、野上昭彦、青沼和隆
    • Organizer
      第28JPIC学会学術集会
    • Place of Presentation
      学術総合センター、東京都、千代田区
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Sports Allowance/Restriction in the Patients with Long QT Syndrome2017

    • Author(s)
      Kato Y
    • Organizer
      APHRS 2017/JHRS 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Age Dependent Changes of T Wave Polarity in Japanese School Children2017

    • Author(s)
      Kato Y, Izumida N, Iwamoto M, Horigome H, Ushinohama H, Sumitomo N, Tauchi N, Abe K, Yoshinaga M, Nagashima M
    • Organizer
      APHRS 2017/JHRS 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Percutaneous Epicardial Ablation of Recurrent Idiopathic Left Ventricular Tachycardia in 15-Year-Old Boy2017

    • Author(s)
      Kato Y, Nogami A, Sekiguchi Y, Komatsu Y, Nozaki Y, Lin L, Yamasaki H, Kuroki K, Aonuma K
    • Organizer
      APHRS 2017/JHRS 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遺伝性不整脈の症例2017

    • Author(s)
      加藤愛章
    • Organizer
      第53回日本小児循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Diagnosis of Fetal Arrhythmia Using Magnetocardiography: Single-Center Experience of 864 Cases2016

    • Author(s)
      Yoshiaki Kato, Yoshihiro Nozaki, Lisheng Lin, Kuniomi Ogata, Akihiko Kandori, Hitoshi Horigome, Kazutaka Aonuma
    • Organizer
      Annual Meeting of the Japanese Heart Rhythm Society 2016
    • Place of Presentation
      札幌コンベンションセンター、北海道、札幌市
    • Year and Date
      2016-07-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 心磁図を用いた不整脈診断-胎児から成人まで-2016

    • Author(s)
      加藤愛章、稲葉武、林立申、野崎良寛、高橋実穂、中村昭宏、堀米仁志
    • Organizer
      第52回日本小児循環器学会総会・学術集会
    • Place of Presentation
      東京ドームホテル、東京都、文京区
    • Year and Date
      2016-07-06
    • Related Report
      2016 Research-status Report
  • [Book] 学校心臓検診実践マニュアルQ&A : 突然死の可能性のある疾患の早期発見のために2018

    • Author(s)
      日本小児循環器学会
    • Total Pages
      5
    • Publisher
      診断と治療社
    • ISBN
      9784787823366
    • Related Report
      2018 Annual Research Report
  • [Book] 小児・成育循環器学2018

    • Author(s)
      日本小児循環器学会
    • Total Pages
      4
    • Publisher
      診断と治療社
    • ISBN
      9784787822888
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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