| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In an epicutaneously sensitized food allergy model mice, exacerbation or alleviation of skin inflammation enhanced or reduced allergic symptoms induced by oral challenge of food allergen. It has been proved that skin inflammation without transcutaneous allergen exposure could modify food allergy. As the underlying mechanisms, it was suggested that basophils and Th2 cytokines induced by skin inflammation may affect not only local skin sites but also mast cells and eosinophils in the intestinal mucosa. In the case of food allergy associated with skin inflammation such as atopic dermatitis, it is thought that therapeutic intervention for skin symptoms may lead to reduction of food allergy symptoms.
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