The study of the mechanism of development in children with congenital anomaly of kidney and urinary tract, in hot attention to renin-angiotensin system

• Project/Area Number: 16K19643
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kobe University
• Principal Investigator: Shingo Ishimori 神戸大学, 医学研究科, 医学研究員 (30465950)
• Research Collaborator: Iijima Kazumoto (Nozu Kandai)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: レニン・アンギオテンシン系 / 先天性腎尿路異常 / 慢性腎臓病 / レニンアンギオテンシン系 / 先天性腎尿路奇形 / 生理学 / 遺伝学

Outline of Final Research Achievements

The level of urinary Angiotensinogen between in Hydronephrosis and control group were no statistical difference. Compared with control and Hydronephrosis group,
urinary Angiotensinogen level in multiple cystic dysplastic kidney group was significantly higher.

Academic Significance and Societal Importance of the Research Achievements

多嚢胞性異形成腎の発生には、循環レニン・アンギオテンシン系とは別の、局所レニン・アンギオテンシン系の関連があるかもしれない。