The effect of oral immunotherapy on class switching and change in avidity of allergen-specific immunoglobulin
Project/Area Number |
16K19648
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
|
Research Institution | The University of Tokushima |
Principal Investigator |
SUGIMOTO Mayumi 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (20771314)
|
Research Collaborator |
KIDO Hiroshi
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 食物アレルギー / 経口免疫療法 / 抗原特異的免疫グロブリン / アレルギー / 食品 |
Outline of Final Research Achievements |
This study aims to identify the factors which predict the therapeutic effects and to elucidate the mechanism of oral immunotherapy (OIT) by measuring serum allergen-specific immunoglobulins. The response to OIT was associated with significant increases in serum allergen-specific IgG1 levels after up-dosing phase and high baseline IgA levels, compared with small changes in immunoglobulin response in low-responders. The characteristic IgG1 changes and IgA levels in the responders could be potentially useful biomarkers for the prediction of positive clinical response to OIT. The avidity of allergen-specific IgE after OIT was also significantly decreased in high-responders, suggesting that it might be involved in the mechanism of OIT.
|
Report
(3 results)
Research Products
(10 results)