| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
This study aims to identify the factors which predict the therapeutic effects and to elucidate the mechanism of oral immunotherapy (OIT) by measuring serum allergen-specific immunoglobulins. The response to OIT was associated with significant increases in serum allergen-specific IgG1 levels after up-dosing phase and high baseline IgA levels, compared with small changes in immunoglobulin response in low-responders. The characteristic IgG1 changes and IgA levels in the responders could be potentially useful biomarkers for the prediction of positive clinical response to OIT. The avidity of allergen-specific IgE after OIT was also significantly decreased in high-responders, suggesting that it might be involved in the mechanism of OIT.
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