Analysis of the mechanisms of the severe atopic dermatitis in a mouse model of Hyper-IgE syndrome
| Project/Area Number |
16K19649
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
WADA Takeshi 徳島大学, 先端酵素学研究所(プロテオ), 特任助教 (80583418)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 高IgE症候群 / 皮膚炎 / アトピー性皮膚炎 / アレルギー・ぜんそく / 免疫学 |
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| Outline of Final Research Achievements |
To investigate a molecular mechanism underlying the severe atopic dermatitis in patient of Hyper-IgE syndrome (HIES), atopic dermatitis was elicited by repeated oxazolone (Ox) application to the ear of STAT3-DN mice, a mouse model of HIES, and cutaneous inflammatory responses were evaluated. We observed that abnormal immune reaction is responsible for severe inflammatory responses in repeated Ox-challenged STAT3-DN mice.
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Report
(3 results)
Research Products
(5 results)
