The importance of alternative polyadenylation on the depeloepment of neurodepelopmental disorder.
| Project/Area Number |
16K19659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発達障害 / 社会性行動 / 選択的polyA付加 / 情動制御 / 選択的polyA付加反応 / 脳・神経 |
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| Outline of Final Research Achievements |
In this study, we investigated the behavior of mice heterozygous for protein X that involved in alternative polyadenylation. The protein X heterozygote mice were not showed the deficient for open filed test. On the other hand, they had abnormalities in the social behaviors. Next, we investigated the gene expression and 3′UTR length by RNA-sequence. Protein X deficient were induced the change of 3′UTR length in the several genes. This change may induce the deficient of sociability. Furthermore, the overexpression of protein X in the PC12 cells were modulated the neurite formation induced by NGF.
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Report
(3 results)
Research Products
(1 results)
