| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Background: Characterization of regulatory T cells (Tregs) is important for the treatment and prevention of autoimmune diseases and allergies. Tregs are known to be actively induced throughout the fetal and neonatal periods. However, it is unknown why Tregs are induced more in the perinatal period than in adults. This study investigated the hypothesis that neonatal ability to inhibit HDAC activity is related to Tregs induction at the fetal and neonatal stage. Methods: The ability of umbilical cord blood and adult serum to inhibit HDAC was compared by enzyme assays. Results: Neonatal blood had significantly higher ability to inhibit HDAC11 activity than did the blood from adults (P<0.005). Conclusion: This is the first comparison of the ability to inhibit HDAC activity between adult and neonatal human sera.Since HDAC11 is known to inhibit the expression of FOXP3, our results suggest that Tregs are induced by the increased inhibition of HDAC11 during the perinatal period.
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