Molecular mechanisms for regression of matured synapses as a neuronal basis for Rett syndrome
| Project/Area Number |
16K19672
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | National Institute for Physiological Sciences (2017)
Tokyo Women's Medical University (2016) |
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Principal Investigator |
Narushima Madoka 生理学研究所, 基盤神経科学研究領域, 准教授 (30596177)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | シナプス / 発達 / 維持 / mGluR1 / MeCP2 / レット症候群 / 代謝型グルタミン酸受容体 / 外側膝状体 / 退行 / 脳・神経 / 脳神経疾患 / 神経科学 / 生理学 |
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| Outline of Final Research Achievements |
Rett syndrome is a neurodevelopmental disorder that is induced by a genetic mutation of the Methyl CPG-binding protein 2 (MeCP2) and that is characteristic for regression of once acquired cognitive functions and behaviors. Regression of matured synaptic connectivity has been reported in the afferent synapses of the visual thalamus in MeCP2-knockout (KO) mice but molecular mechanisms underlying regression of synaptic connectivity in relation with MeCP2 was unclear. We reported that KO mice of the metabotropic glutamate receptor subtype 1 (mGluR1) showed similar phenotype as MeCP2-KO mice that exhibited regression of once matured synaptic connectivity in the visual thalamus. mGluR1 expressed in a similar developmental time course with MeCP2 and was necessary and sufficient for maintenance of matured synaptic connectivity in the thalamic afferent synapses. These results strongly suggest that mGluR1 and MeCP2 have strong relationship in the maintenance of matured neuronal circuits.
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Report
(3 results)
Research Products
(9 results)
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[Presentation] The metabotropic glutamate receptor subtype 1 mediates visual experience-dependent maintenance of synaptic connectivity in the dorsal lateral geniculate nucleus.2017
Author(s)
Madoka Naruhsima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata, Masanobu Kano
Organizer
Neuroscience 2017
Related Report
Int'l Joint Research
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