Research Project
Grant-in-Aid for Young Scientists (B)
Rett syndrome is a neurodevelopmental disorder that is induced by a genetic mutation of the Methyl CPG-binding protein 2 (MeCP2) and that is characteristic for regression of once acquired cognitive functions and behaviors. Regression of matured synaptic connectivity has been reported in the afferent synapses of the visual thalamus in MeCP2-knockout (KO) mice but molecular mechanisms underlying regression of synaptic connectivity in relation with MeCP2 was unclear. We reported that KO mice of the metabotropic glutamate receptor subtype 1 (mGluR1) showed similar phenotype as MeCP2-KO mice that exhibited regression of once matured synaptic connectivity in the visual thalamus. mGluR1 expressed in a similar developmental time course with MeCP2 and was necessary and sufficient for maintenance of matured synaptic connectivity in the thalamic afferent synapses. These results strongly suggest that mGluR1 and MeCP2 have strong relationship in the maintenance of matured neuronal circuits.
All 2018 2017 2016 Other
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results, Invited: 1 results) Remarks (1 results)
Neuroscience Research
Volume: 129 Pages: 24-31
10.1016/j.neures.2017.06.004
Neuron
Volume: 91 Issue: 5 Pages: 1097-1109
10.1016/j.neuron.2016.07.035
http://www.twmu.ac.jp/univ/news/index.php?kbn=1&ym=201608
