| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The substantial risk of iron overload is not routinely monitored in most of the neonatal intensive care units (NICUs) in Japan; however, blood transfusion is an essential strategy for successfully treating preterm low-birth-weight infants.The aim of this study was to investigate the iron status and clinical features of very-low-birth-weight infants (VLBWIs). This prospective observational study enrolled 176 patients from a total of 213 VLBWIs admitted to our NICU from 2009 to 2014. Twenty-four infants displayed hyperferritinemia. A multiple logistic analysis selected 3 associated factors of hyperferritinemia: surgical ligation for patent ductus arteriosus, sepsis and bronchopulmonary dysplasia. Additionally,the initial interaction between ERFE and hepcidin in VLBWIs may be insufficient due to prematurity.The physiological function of iron regulators may possibly be observable only after stabilization and gradual maturation of organ systems towards the end of the postnatal period.
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